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Vitamin C Intake and Pancreatic Cancer Risk: A Meta-Analysis of Published Case-Control and Cohort Studies.

Abstract

BACKGROUND

Observational studies inconsistently reported the relationship between vitamin C intake and risk of pancreatic cancer. We conducted a meta-analysis of published case-control and cohort studies to quantify the association.

METHODS

Potentially eligible studies were found on PubMed and EMBASE databases through May 31, 2015. A random-effects model was assigned to compute summary point estimates with corresponding 95% confidence intervals (CIs). Subgroup and meta-regression analyses were also performed to explore sources of heterogeneity.

RESULTS

Our final analyses included 20 observational studies comprising nearly 5 thousand cases of pancreatic cancer. When comparing the highest with the lowest categories of vitamin C intake, the summary odds ratio/relative risk for case-control studies (14 studies), cohort studies (6 studies) and all studies combined was 0.58 (95% CI: 0.52-0.66), 0.93 (95% CI: 0.78-1.11) and 0.66 (95% CI: 0.58-0.75), respectively. The difference in the findings between case-control and cohort studies was statistically significant (P < .001). Possible publication bias was shown in the meta-analysis of case-control studies.

CONCLUSION

There is insufficient evidence to conclude any relationship between vitamin C intake and risk of pancreatic cancer. The strong inverse association observed in case-control studies may be affected by biases (eg, recall and selection biases) that particularly affect case-control studies and/or potential publication bias. Future prospective studies of vitamin C intake and pancreatic cancer are needed.

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  • Authors+Show Affiliations

    ,

    Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.

    ,

    Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.

    ,

    Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.

    ,

    Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.

    ,

    Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China.

    Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, 315000, China.

    Source

    PloS one 11:2 2016 pg e0148816

    MeSH

    Antioxidants
    Ascorbic Acid
    Case-Control Studies
    Cohort Studies
    Humans
    Pancreatic Neoplasms
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    26859881

    Citation

    Hua, Yong-Fei, et al. "Vitamin C Intake and Pancreatic Cancer Risk: a Meta-Analysis of Published Case-Control and Cohort Studies." PloS One, vol. 11, no. 2, 2016, pp. e0148816.
    Hua YF, Wang GQ, Jiang W, et al. Vitamin C Intake and Pancreatic Cancer Risk: A Meta-Analysis of Published Case-Control and Cohort Studies. PLoS ONE. 2016;11(2):e0148816.
    Hua, Y. F., Wang, G. Q., Jiang, W., Huang, J., Chen, G. C., & Lu, C. D. (2016). Vitamin C Intake and Pancreatic Cancer Risk: A Meta-Analysis of Published Case-Control and Cohort Studies. PloS One, 11(2), pp. e0148816. doi:10.1371/journal.pone.0148816.
    Hua YF, et al. Vitamin C Intake and Pancreatic Cancer Risk: a Meta-Analysis of Published Case-Control and Cohort Studies. PLoS ONE. 2016;11(2):e0148816. PubMed PMID: 26859881.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin C Intake and Pancreatic Cancer Risk: A Meta-Analysis of Published Case-Control and Cohort Studies. AU - Hua,Yong-Fei, AU - Wang,Gao-Qing, AU - Jiang,Wei, AU - Huang,Jing, AU - Chen,Guo-Chong, AU - Lu,Cai-De, Y1 - 2016/02/09/ PY - 2015/07/09/received PY - 2016/01/22/accepted PY - 2016/2/10/entrez PY - 2016/2/10/pubmed PY - 2016/7/20/medline SP - e0148816 EP - e0148816 JF - PloS one JO - PLoS ONE VL - 11 IS - 2 N2 - BACKGROUND: Observational studies inconsistently reported the relationship between vitamin C intake and risk of pancreatic cancer. We conducted a meta-analysis of published case-control and cohort studies to quantify the association. METHODS: Potentially eligible studies were found on PubMed and EMBASE databases through May 31, 2015. A random-effects model was assigned to compute summary point estimates with corresponding 95% confidence intervals (CIs). Subgroup and meta-regression analyses were also performed to explore sources of heterogeneity. RESULTS: Our final analyses included 20 observational studies comprising nearly 5 thousand cases of pancreatic cancer. When comparing the highest with the lowest categories of vitamin C intake, the summary odds ratio/relative risk for case-control studies (14 studies), cohort studies (6 studies) and all studies combined was 0.58 (95% CI: 0.52-0.66), 0.93 (95% CI: 0.78-1.11) and 0.66 (95% CI: 0.58-0.75), respectively. The difference in the findings between case-control and cohort studies was statistically significant (P < .001). Possible publication bias was shown in the meta-analysis of case-control studies. CONCLUSION: There is insufficient evidence to conclude any relationship between vitamin C intake and risk of pancreatic cancer. The strong inverse association observed in case-control studies may be affected by biases (eg, recall and selection biases) that particularly affect case-control studies and/or potential publication bias. Future prospective studies of vitamin C intake and pancreatic cancer are needed. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26859881/Vitamin_C_Intake_and_Pancreatic_Cancer_Risk:_A_Meta_Analysis_of_Published_Case_Control_and_Cohort_Studies_ L2 - http://dx.plos.org/10.1371/journal.pone.0148816 DB - PRIME DP - Unbound Medicine ER -