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Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk.
Nutrients 2016; 8(2):80N

Abstract

Selenium (Se) is a micronutrient that maintains biological functions through the action of Se containing proteins known as selenoproteins. Due to the known antioxidant effects of Se, supplements containing Se have been on the rise. While Se supplementation may be beneficial for Se deficient populations, few are at risk for Se deficiency due to the transportation of food from Se-rich regions and the rise of Se-enriched foods. Alarmingly, Se supplementation may have adverse effects in people who already receive an adequate Se supply. Specifically, an increased risk of type 2 diabetes has been reported in individuals with high baseline Se levels. However, this effect was restricted to males, suggesting the relationship between Se and glucose homeostasis may be sexually dimorphic. This review will discuss the current understanding of the interaction between Se and glucose homeostasis, including any sex differences that have been described.

Authors+Show Affiliations

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St., Honolulu, HI 96813, USA. anogawa@hawaii.edu.Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St., Honolulu, HI 96813, USA. mberry@hawaii.edu.Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St., Honolulu, HI 96813, USA. lseale@hawaii.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

26861388

Citation

Ogawa-Wong, Ashley N., et al. "Selenium and Metabolic Disorders: an Emphasis On Type 2 Diabetes Risk." Nutrients, vol. 8, no. 2, 2016, p. 80.
Ogawa-Wong AN, Berry MJ, Seale LA. Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. Nutrients. 2016;8(2):80.
Ogawa-Wong, A. N., Berry, M. J., & Seale, L. A. (2016). Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. Nutrients, 8(2), p. 80. doi:10.3390/nu8020080.
Ogawa-Wong AN, Berry MJ, Seale LA. Selenium and Metabolic Disorders: an Emphasis On Type 2 Diabetes Risk. Nutrients. 2016 Feb 6;8(2):80. PubMed PMID: 26861388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. AU - Ogawa-Wong,Ashley N, AU - Berry,Marla J, AU - Seale,Lucia A, Y1 - 2016/02/06/ PY - 2015/12/31/received PY - 2016/02/02/accepted PY - 2016/2/11/entrez PY - 2016/2/11/pubmed PY - 2016/10/25/medline KW - metabolic disease KW - selenium KW - selenoproteins KW - trace element SP - 80 EP - 80 JF - Nutrients JO - Nutrients VL - 8 IS - 2 N2 - Selenium (Se) is a micronutrient that maintains biological functions through the action of Se containing proteins known as selenoproteins. Due to the known antioxidant effects of Se, supplements containing Se have been on the rise. While Se supplementation may be beneficial for Se deficient populations, few are at risk for Se deficiency due to the transportation of food from Se-rich regions and the rise of Se-enriched foods. Alarmingly, Se supplementation may have adverse effects in people who already receive an adequate Se supply. Specifically, an increased risk of type 2 diabetes has been reported in individuals with high baseline Se levels. However, this effect was restricted to males, suggesting the relationship between Se and glucose homeostasis may be sexually dimorphic. This review will discuss the current understanding of the interaction between Se and glucose homeostasis, including any sex differences that have been described. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26861388/Selenium_and_Metabolic_Disorders:_An_Emphasis_on_Type_2_Diabetes_Risk_ L2 - http://www.mdpi.com/resolver?pii=nu8020080 DB - PRIME DP - Unbound Medicine ER -