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[The therapeutic effectiveness of chestnut extract].
Wien Med Wochenschr. 1989 Sep 15; 139(17):385-9.WM

Abstract

On the basis of numerous pharmacological, clinical pharmacological and clinical investigations it could be proved, that Venostasin ret., standardized on 50 mg triterpenglycosides, calculated as escine, has effects on the venous system: It has tonical effects on the veins, decreases permeability and has protective and curative properties. The mechanism of action is not fully understood, although there are some new interesting biochemical aspects regarding the attenuation of lysosomal proteoglycan destructing enzymes, which are increasingly active in patients with chronic venal insufficiency. In several double-blind randomized cross-over studies it could be demonstrated, that subjective complaints are effectively diminished. As far as objective test variables are concerned (edema), the clinical effectiveness could be shown on the basis of exact biometrical investigations. Thus the therapeutic usefulness for the treatment of chronic venal insufficiency is proven. Furthermore, regarding the good tolerability of the drug, the use of it can be recommended.

Authors+Show Affiliations

Abteilung für Klinische Pharmakologie, I. Medizinische Universitätsklinik, Wien.

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Review

Language

ger

PubMed ID

2686181

Citation

Hitzenberger, G. "[The Therapeutic Effectiveness of Chestnut Extract]." Wiener Medizinische Wochenschrift (1946), vol. 139, no. 17, 1989, pp. 385-9.
Hitzenberger G. [The therapeutic effectiveness of chestnut extract]. Wien Med Wochenschr. 1989;139(17):385-9.
Hitzenberger, G. (1989). [The therapeutic effectiveness of chestnut extract]. Wiener Medizinische Wochenschrift (1946), 139(17), 385-9.
Hitzenberger G. [The Therapeutic Effectiveness of Chestnut Extract]. Wien Med Wochenschr. 1989 Sep 15;139(17):385-9. PubMed PMID: 2686181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The therapeutic effectiveness of chestnut extract]. A1 - Hitzenberger,G, PY - 1989/9/15/pubmed PY - 1989/9/15/medline PY - 1989/9/15/entrez SP - 385 EP - 9 JF - Wiener medizinische Wochenschrift (1946) JO - Wien Med Wochenschr VL - 139 IS - 17 N2 - On the basis of numerous pharmacological, clinical pharmacological and clinical investigations it could be proved, that Venostasin ret., standardized on 50 mg triterpenglycosides, calculated as escine, has effects on the venous system: It has tonical effects on the veins, decreases permeability and has protective and curative properties. The mechanism of action is not fully understood, although there are some new interesting biochemical aspects regarding the attenuation of lysosomal proteoglycan destructing enzymes, which are increasingly active in patients with chronic venal insufficiency. In several double-blind randomized cross-over studies it could be demonstrated, that subjective complaints are effectively diminished. As far as objective test variables are concerned (edema), the clinical effectiveness could be shown on the basis of exact biometrical investigations. Thus the therapeutic usefulness for the treatment of chronic venal insufficiency is proven. Furthermore, regarding the good tolerability of the drug, the use of it can be recommended. SN - 0043-5341 UR - https://www.unboundmedicine.com/medline/citation/2686181/[The_therapeutic_effectiveness_of_chestnut_extract]_ L2 - https://antibodies.cancer.gov/detail/CPTC-HLA-B-1 DB - PRIME DP - Unbound Medicine ER -