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Barrier Function and Natural Moisturizing Factor Levels After Cumula-tive Exposure to Short-chain Aliphatic Alcohols and Detergents: Results of Occlusion-modified Tandem Repeated Irritation Test.
Acta Derm Venereol. 2016 Nov 02; 96(7):880-884.AD

Abstract

Alcohol-based disinfectants and detergents are common workplace factors for irritant contact dermatitis (ICD). Though occlusion and water are relevant co-exposures, the tandem effects of occlusion and sequential exposure to alcohols and detergents have not been studied. We therefore investigated the combined effects of occlusion with water and repeated exposure to n-propanol and/or sodium lauryl sulphate (SLS) in an occlusion-modified tandem irritation test. The outcomes included visual scoring, measurement of erythema, transepidermal water loss, capacitance and natural moisturizing factor (NMF) levels. Occlusion abrogated the skin barrier function and significantly enhanced the irritant-induced barrier damaging effects. The NMF levels of all irritant-exposed fields decreased significantly compared with the non-exposed fields; occlusion enhanced the decrease in NMF. Although SLS exerted more pronounced effects on the measured parameters, the barrier function impairment and NMF decrease after exposure to n-propanol in workplace-relevant concentrations, found in the study, confirm the significance of short-chain aliphatic alcohols for occupational ICD.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Angelova-Fischer I
Department of Dermatology, University of Lübeck, DE-23538 Lübeck, Germany. Irena.Angelova-Fischer@uksh.de.
Stilla T
No affiliation info available
Kezic S
No affiliation info available
Fischer TW
No affiliation info available
Zillikens D
No affiliation info available

MeSH

1-PropanolAdultAgedChromatography, High Pressure LiquidDermatitis, IrritantDermatitis, OccupationalErythemaFemaleHumansIrritantsMaleMiddle AgedSkin TestsSodium Dodecyl SulfateWater Loss, Insensible

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26864715

Citation

Angelova-Fischer, Irena, et al. "Barrier Function and Natural Moisturizing Factor Levels After Cumula-tive Exposure to Short-chain Aliphatic Alcohols and Detergents: Results of Occlusion-modified Tandem Repeated Irritation Test." Acta Dermato-venereologica, vol. 96, no. 7, 2016, pp. 880-884.
Angelova-Fischer I, Stilla T, Kezic S, et al. Barrier Function and Natural Moisturizing Factor Levels After Cumula-tive Exposure to Short-chain Aliphatic Alcohols and Detergents: Results of Occlusion-modified Tandem Repeated Irritation Test. Acta Derm Venereol. 2016;96(7):880-884.
Angelova-Fischer, I., Stilla, T., Kezic, S., Fischer, T. W., & Zillikens, D. (2016). Barrier Function and Natural Moisturizing Factor Levels After Cumula-tive Exposure to Short-chain Aliphatic Alcohols and Detergents: Results of Occlusion-modified Tandem Repeated Irritation Test. Acta Dermato-venereologica, 96(7), 880-884. https://doi.org/10.2340/00015555-2363
Angelova-Fischer I, et al. Barrier Function and Natural Moisturizing Factor Levels After Cumula-tive Exposure to Short-chain Aliphatic Alcohols and Detergents: Results of Occlusion-modified Tandem Repeated Irritation Test. Acta Derm Venereol. 2016 Nov 2;96(7):880-884. PubMed PMID: 26864715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Barrier Function and Natural Moisturizing Factor Levels After Cumula-tive Exposure to Short-chain Aliphatic Alcohols and Detergents: Results of Occlusion-modified Tandem Repeated Irritation Test. AU - Angelova-Fischer,Irena, AU - Stilla,Tasja, AU - Kezic,Sanja, AU - Fischer,Tobias W, AU - Zillikens,Detlef, PY - 2016/2/13/pubmed PY - 2017/1/20/medline PY - 2016/2/12/entrez SP - 880 EP - 884 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 96 IS - 7 N2 - Alcohol-based disinfectants and detergents are common workplace factors for irritant contact dermatitis (ICD). Though occlusion and water are relevant co-exposures, the tandem effects of occlusion and sequential exposure to alcohols and detergents have not been studied. We therefore investigated the combined effects of occlusion with water and repeated exposure to n-propanol and/or sodium lauryl sulphate (SLS) in an occlusion-modified tandem irritation test. The outcomes included visual scoring, measurement of erythema, transepidermal water loss, capacitance and natural moisturizing factor (NMF) levels. Occlusion abrogated the skin barrier function and significantly enhanced the irritant-induced barrier damaging effects. The NMF levels of all irritant-exposed fields decreased significantly compared with the non-exposed fields; occlusion enhanced the decrease in NMF. Although SLS exerted more pronounced effects on the measured parameters, the barrier function impairment and NMF decrease after exposure to n-propanol in workplace-relevant concentrations, found in the study, confirm the significance of short-chain aliphatic alcohols for occupational ICD. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/26864715/Barrier_Function_and_Natural_Moisturizing_Factor_Levels_After_Cumula_tive_Exposure_to_Short_chain_Aliphatic_Alcohols_and_Detergents:_Results_of_Occlusion_modified_Tandem_Repeated_Irritation_Test_ DB - PRIME DP - Unbound Medicine ER -