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Ficus recemosa bark extract attenuates diabetic complications and oxidative stress in STZ-induced diabetic rats.
Pharm Biol. 2016 Sep; 54(9):1586-95.PB

Abstract

Context Ficus recemosa Linn. (Moraceae) has been reported as a natural folk medicine with diverse pathological activities such as antioxidant, antidiabetic, renoprotective and cardioprotective. Objective The present study evaluates the preventive effect of standardised ethanol extract of F. racemosa stem bark (EEFSB) on diabetic cardiomyopathy (DC) and diabetic nephropathy (DN). Materials and methods Animals were rendered diabetic by one time administration of STZ (45 mg kg(-1), i.v.) and, after 7 d, diabetic rats were randomised into four groups of eight rats each. EEFSB (200 and 400 mg kg(-1)) was administered to diabetic rats once daily for 8 weeks. Furthermore, the presence of phytochemicals was evaluated by HPTLC. Results Treatment with EEFSB markedly restores the blood glucose and lipid level (p < 0.001), also reduced creatinine kinase (p < 0.001), lactate dehydrogenase (p < 0.001), C-reactive protein (p < 0.001), creatinine (p < 0.001), blood urea nitrogen (p < 0.001), collagen (p < 0.05) and albumin (p < 0.001) levels. Reduced level of sodium (p < 0.001), creatinine (p < 0.001), albumin (p < 0.001) and malondialdehyde (p < 0.01) in heart and kidney tissue along with enhanced activities of superoxide dismutase (p < 0.001) and reduced glutathione (p < 0.001). Moreover, left ventricular hypertrophic index and cardiac hypertrophic index were markedly reduced by EEFSB treatment. Conclusion The findings of this study provided strong scientific evidence for the traditional use of F. racemosa and postulate protective effects against diabetes and its complications such as DC and DN.

Authors+Show Affiliations

a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.a Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26864816

Citation

Joshi, Hiral, et al. "Ficus Recemosa Bark Extract Attenuates Diabetic Complications and Oxidative Stress in STZ-induced Diabetic Rats." Pharmaceutical Biology, vol. 54, no. 9, 2016, pp. 1586-95.
Joshi H, Vaishnav D, Sanghvi G, et al. Ficus recemosa bark extract attenuates diabetic complications and oxidative stress in STZ-induced diabetic rats. Pharm Biol. 2016;54(9):1586-95.
Joshi, H., Vaishnav, D., Sanghvi, G., Rabadia, S., Airao, V., Sharma, T., Parmar, S., & Sheth, N. (2016). Ficus recemosa bark extract attenuates diabetic complications and oxidative stress in STZ-induced diabetic rats. Pharmaceutical Biology, 54(9), 1586-95. https://doi.org/10.3109/13880209.2015.1110596
Joshi H, et al. Ficus Recemosa Bark Extract Attenuates Diabetic Complications and Oxidative Stress in STZ-induced Diabetic Rats. Pharm Biol. 2016;54(9):1586-95. PubMed PMID: 26864816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ficus recemosa bark extract attenuates diabetic complications and oxidative stress in STZ-induced diabetic rats. AU - Joshi,Hiral, AU - Vaishnav,Devendra, AU - Sanghvi,Gaurav, AU - Rabadia,Samir, AU - Airao,Vishal, AU - Sharma,Tejas, AU - Parmar,Sachin, AU - Sheth,Navin, Y1 - 2016/02/10/ PY - 2016/2/12/entrez PY - 2016/2/13/pubmed PY - 2017/2/14/medline KW - Antioxidants KW - cardiomyopathy KW - diabetes mellitus KW - nephropathy SP - 1586 EP - 95 JF - Pharmaceutical biology JO - Pharm Biol VL - 54 IS - 9 N2 - Context Ficus recemosa Linn. (Moraceae) has been reported as a natural folk medicine with diverse pathological activities such as antioxidant, antidiabetic, renoprotective and cardioprotective. Objective The present study evaluates the preventive effect of standardised ethanol extract of F. racemosa stem bark (EEFSB) on diabetic cardiomyopathy (DC) and diabetic nephropathy (DN). Materials and methods Animals were rendered diabetic by one time administration of STZ (45 mg kg(-1), i.v.) and, after 7 d, diabetic rats were randomised into four groups of eight rats each. EEFSB (200 and 400 mg kg(-1)) was administered to diabetic rats once daily for 8 weeks. Furthermore, the presence of phytochemicals was evaluated by HPTLC. Results Treatment with EEFSB markedly restores the blood glucose and lipid level (p < 0.001), also reduced creatinine kinase (p < 0.001), lactate dehydrogenase (p < 0.001), C-reactive protein (p < 0.001), creatinine (p < 0.001), blood urea nitrogen (p < 0.001), collagen (p < 0.05) and albumin (p < 0.001) levels. Reduced level of sodium (p < 0.001), creatinine (p < 0.001), albumin (p < 0.001) and malondialdehyde (p < 0.01) in heart and kidney tissue along with enhanced activities of superoxide dismutase (p < 0.001) and reduced glutathione (p < 0.001). Moreover, left ventricular hypertrophic index and cardiac hypertrophic index were markedly reduced by EEFSB treatment. Conclusion The findings of this study provided strong scientific evidence for the traditional use of F. racemosa and postulate protective effects against diabetes and its complications such as DC and DN. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/26864816/Ficus_recemosa_bark_extract_attenuates_diabetic_complications_and_oxidative_stress_in_STZ_induced_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2015.1110596 DB - PRIME DP - Unbound Medicine ER -