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The genetic background of Parkinson's disease: current progress and future prospects.
Acta Neurol Scand. 2016 Nov; 134(5):314-326.AN

Abstract

Almost two decades of genetic research in Parkinson's disease (PD) have remarkably increased our knowledge regarding the genetic basis of PD with numerous genes and genetic loci having been found to cause familial PD or affect the risk for PD. Approximately 5-10% of PD patients have monogenic forms of the disease, exhibiting a classical Mendelian type of inheritance, however, the majority PD cases are sporadic, probably caused by a combination of genetic and environmental risk factors. Nowadays, six genes, alpha synuclein, LRRK2, VPS35, Parkin, PINK1 and DJ-1, have definitely been associated with an autosomal dominant or recessive PD mode of inheritance. The advent of genome-wide association studies (GWAS) and the implementation of new technologies, like next generation sequencing (NGS) and exome sequencing has undoubtedly greatly aided the identification on novel risk variants for sporadic PD. In this review, we will summarize the current progress and future prospects in the field of PD genetics.

Authors+Show Affiliations

Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.3rd University Department of Neurology, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. lfidani@med.auth.gr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26869347

Citation

Kalinderi, K, et al. "The Genetic Background of Parkinson's Disease: Current Progress and Future Prospects." Acta Neurologica Scandinavica, vol. 134, no. 5, 2016, pp. 314-326.
Kalinderi K, Bostantjopoulou S, Fidani L. The genetic background of Parkinson's disease: current progress and future prospects. Acta Neurol Scand. 2016;134(5):314-326.
Kalinderi, K., Bostantjopoulou, S., & Fidani, L. (2016). The genetic background of Parkinson's disease: current progress and future prospects. Acta Neurologica Scandinavica, 134(5), 314-326. https://doi.org/10.1111/ane.12563
Kalinderi K, Bostantjopoulou S, Fidani L. The Genetic Background of Parkinson's Disease: Current Progress and Future Prospects. Acta Neurol Scand. 2016;134(5):314-326. PubMed PMID: 26869347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The genetic background of Parkinson's disease: current progress and future prospects. AU - Kalinderi,K, AU - Bostantjopoulou,S, AU - Fidani,L, Y1 - 2016/02/12/ PY - 2016/01/11/accepted PY - 2016/2/13/pubmed PY - 2017/1/18/medline PY - 2016/2/13/entrez KW - GBA KW - gene KW - lysosomes KW - parkinson's disease KW - pathway KW - risk factor SP - 314 EP - 326 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 134 IS - 5 N2 - Almost two decades of genetic research in Parkinson's disease (PD) have remarkably increased our knowledge regarding the genetic basis of PD with numerous genes and genetic loci having been found to cause familial PD or affect the risk for PD. Approximately 5-10% of PD patients have monogenic forms of the disease, exhibiting a classical Mendelian type of inheritance, however, the majority PD cases are sporadic, probably caused by a combination of genetic and environmental risk factors. Nowadays, six genes, alpha synuclein, LRRK2, VPS35, Parkin, PINK1 and DJ-1, have definitely been associated with an autosomal dominant or recessive PD mode of inheritance. The advent of genome-wide association studies (GWAS) and the implementation of new technologies, like next generation sequencing (NGS) and exome sequencing has undoubtedly greatly aided the identification on novel risk variants for sporadic PD. In this review, we will summarize the current progress and future prospects in the field of PD genetics. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/26869347/The_genetic_background_of_Parkinson's_disease:_current_progress_and_future_prospects_ L2 - https://doi.org/10.1111/ane.12563 DB - PRIME DP - Unbound Medicine ER -
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