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Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases.
Mult Scler. 2016 12; 22(14):1821-1829.MS

Abstract

BACKGROUND

Myelin oligodendrocyte glycoprotein (MOG) antibodies have been described in children with acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, neuromyelitis optica spectrum disorders and more recently in children with multiphasic disseminated encephalomyelitis (MDEM).

OBJECTIVE

To delineate the clinical, cerebrospinal fluid (CSF) and radiological features of paediatric MDEM with MOG antibodies.

METHODS

Clinical course, serum antibodies, CSF, magnetic resonance imaging (MRI) studies and outcome of paediatric MDEM patients were reviewed.

RESULTS

A total of 8 children with two or more episodes of ADEM were identified from a cohort of 295 children with acute demyelinating events. All children had persisting MOG antibodies (median titre: 1:1280). All ADEM episodes included encephalopathy, polyfocal neurological signs and a typical MRI. Apart from ADEM episodes, three children had further clinical attacks without encephalopathy. Median age at initial presentation was 3 years (range: 1-7 years) and median follow-up 4 years (range: 1-8 years). New ADEM episodes were associated with new neurological signs and new MRI lesions. Clinical outcome did range from normal (four of the eight) to mild or moderate impairment (four of the eight). A total of four children received monthly immunoglobulin treatment during the disease course.

CONCLUSION

Children with MDEM and persisting MOG antibodies constitute a distinct entity of relapsing demyelinating events and extend the spectrum of MOG antibody-associated diseases.

Authors+Show Affiliations

Baumann M
Department of Paediatrics I, Paediatric Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Hennes EM
Olga Hospital, Children's Hospital Stuttgart, Stuttgart, Germany.
Schanda K
Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Karenfort M
Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Kornek B
Department of Neurology, Medical University of Vienna, Vienna, Austria.
Seidl R
Department of Paediatrics, Medical University of Vienna, Vienna, Austria.
Diepold K
Department of Paediatric Neurology, Children's Hospital, Kassel, Germany.
Lauffer H
Department of Neuropaediatrics and Metabolic Diseases, Greifswald University Hospital, Greifswald, Germany.
Marquardt I
Paediatric Neurology, University Children's Hospital, Oldenburg, Germany.
Strautmanis J
Department of Neurology, Children's Clinical University Hospital, Riga, Latvia.
Syrbe S
University Hospital for Children and Adolescents, Leipzig, Germany.
Vieker S
Children's Hospital Bayreuth, Bayreuth, Germany.
Höftberger R
Institute of Neurology, Medical University of Vienna, Vienna, Austria.
Reindl M
Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Rostásy K
Department of Paediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University, Datteln, Germany k.rostasy@kinderklinik-datteln.de.

MeSH

AutoantibodiesChildChild, PreschoolDemyelinating Autoimmune Diseases, CNSEncephalomyelitisFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMyelin-Oligodendrocyte Glycoprotein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26869530

Citation

Baumann, Matthias, et al. "Children With Multiphasic Disseminated Encephalomyelitis and Antibodies to the Myelin Oligodendrocyte Glycoprotein (MOG): Extending the Spectrum of MOG Antibody Positive Diseases." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 22, no. 14, 2016, pp. 1821-1829.
Baumann M, Hennes EM, Schanda K, et al. Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases. Mult Scler. 2016;22(14):1821-1829.
Baumann, M., Hennes, E. M., Schanda, K., Karenfort, M., Kornek, B., Seidl, R., Diepold, K., Lauffer, H., Marquardt, I., Strautmanis, J., Syrbe, S., Vieker, S., Höftberger, R., Reindl, M., & Rostásy, K. (2016). Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases. Multiple Sclerosis (Houndmills, Basingstoke, England), 22(14), 1821-1829.
Baumann M, et al. Children With Multiphasic Disseminated Encephalomyelitis and Antibodies to the Myelin Oligodendrocyte Glycoprotein (MOG): Extending the Spectrum of MOG Antibody Positive Diseases. Mult Scler. 2016;22(14):1821-1829. PubMed PMID: 26869530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases. AU - Baumann,Matthias, AU - Hennes,Eva-Maria, AU - Schanda,Kathrin, AU - Karenfort,Michael, AU - Kornek,Barbara, AU - Seidl,Rainer, AU - Diepold,Katharina, AU - Lauffer,Heinz, AU - Marquardt,Iris, AU - Strautmanis,Jurgis, AU - Syrbe,Steffen, AU - Vieker,Silvia, AU - Höftberger,Romana, AU - Reindl,Markus, AU - Rostásy,Kevin, Y1 - 2016/02/11/ PY - 2015/11/27/received PY - 2016/01/04/revised PY - 2016/11/14/accepted PY - 2016/2/13/pubmed PY - 2018/1/27/medline PY - 2016/2/13/entrez KW - Multiphasic disseminated encephalomyelitis KW - acquired demyelinating syndromes KW - acute disseminated encephalomyelitis KW - children KW - magnetic resonance imaging KW - myelin oligodendrocyte glycoprotein SP - 1821 EP - 1829 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult Scler VL - 22 IS - 14 N2 - BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) antibodies have been described in children with acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, neuromyelitis optica spectrum disorders and more recently in children with multiphasic disseminated encephalomyelitis (MDEM). OBJECTIVE: To delineate the clinical, cerebrospinal fluid (CSF) and radiological features of paediatric MDEM with MOG antibodies. METHODS: Clinical course, serum antibodies, CSF, magnetic resonance imaging (MRI) studies and outcome of paediatric MDEM patients were reviewed. RESULTS: A total of 8 children with two or more episodes of ADEM were identified from a cohort of 295 children with acute demyelinating events. All children had persisting MOG antibodies (median titre: 1:1280). All ADEM episodes included encephalopathy, polyfocal neurological signs and a typical MRI. Apart from ADEM episodes, three children had further clinical attacks without encephalopathy. Median age at initial presentation was 3 years (range: 1-7 years) and median follow-up 4 years (range: 1-8 years). New ADEM episodes were associated with new neurological signs and new MRI lesions. Clinical outcome did range from normal (four of the eight) to mild or moderate impairment (four of the eight). A total of four children received monthly immunoglobulin treatment during the disease course. CONCLUSION: Children with MDEM and persisting MOG antibodies constitute a distinct entity of relapsing demyelinating events and extend the spectrum of MOG antibody-associated diseases. SN - 1477-0970 UR - https://www.unboundmedicine.com/medline/citation/26869530/Children_with_multiphasic_disseminated_encephalomyelitis_and_antibodies_to_the_myelin_oligodendrocyte_glycoprotein__MOG_:_Extending_the_spectrum_of_MOG_antibody_positive_diseases_ DB - PRIME DP - Unbound Medicine ER -