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Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by lead acetate in rats.
Redox Rep 2017; 22(1):42-50RR

Abstract

OBJECTIVES

Liver is considered a target organ affected by lead toxicity. Oxidative stress is among the mechanisms involved in liver damage. Here we investigated the effects of the natural alkaloid berberine on oxidative stress and hepatotoxicity induced by lead in rats.

METHODS

Animals received an aqueous solution of lead acetate (500 mg Pb/l in the drinking water) and/or daily oral gavage of berberine (50 mg/kg) for 8 weeks. Rats were then weighed and used for the biochemical, molecular, and histological evaluations.

RESULTS

Lead-induced oxidative stress, shown by increasing lipid peroxidation along with a concomitant decrease in hepatic levels of thiol groups, total antioxidant capacity, the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase, and reduced versus oxidized glutathione ratio. Berberine corrected all the disturbances in oxidative stress markers induced by lead administration. Berberine also prevented the elevated levels of enzymes (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) and the decrease in body weight and albumin. The protective effects of berberine were comparable with silymarin. Furthermore, berberine attenuated liver damage, shown by decreased necrosis and inflammatory cell infiltration.

DISCUSSION

Berberine represents a potential therapeutic option against lead-induced hepatotoxicity through inhibiting lipid peroxidation and enhancing antioxidant defenses.

CONCLUSION

Berberine exerted protective effects on lead-induced oxidative stress and hepatotoxicity in rats.

Authors+Show Affiliations

a Department of Biology , School of Basic Sciences, Bu-Ali Sina University , Hamedan , Iran.a Department of Biology , School of Basic Sciences, Bu-Ali Sina University , Hamedan , Iran.b Department of Medical Biochemistry , School of Medicine, Hamedan University of Medical Sciences , Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26871196

Citation

Hasanein, Parisa, et al. "Effects of Isoquinoline Alkaloid Berberine On Lipid Peroxidation, Antioxidant Defense System, and Liver Damage Induced By Lead Acetate in Rats." Redox Report : Communications in Free Radical Research, vol. 22, no. 1, 2017, pp. 42-50.
Hasanein P, Ghafari-Vahed M, Khodadadi I. Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by lead acetate in rats. Redox Rep. 2017;22(1):42-50.
Hasanein, P., Ghafari-Vahed, M., & Khodadadi, I. (2017). Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by lead acetate in rats. Redox Report : Communications in Free Radical Research, 22(1), pp. 42-50.
Hasanein P, Ghafari-Vahed M, Khodadadi I. Effects of Isoquinoline Alkaloid Berberine On Lipid Peroxidation, Antioxidant Defense System, and Liver Damage Induced By Lead Acetate in Rats. Redox Rep. 2017;22(1):42-50. PubMed PMID: 26871196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of isoquinoline alkaloid berberine on lipid peroxidation, antioxidant defense system, and liver damage induced by lead acetate in rats. AU - Hasanein,Parisa, AU - Ghafari-Vahed,Masumeh, AU - Khodadadi,Iraj, Y1 - 2016/02/15/ PY - 2016/2/13/pubmed PY - 2017/5/16/medline PY - 2016/2/13/entrez KW - Berberine KW - Hepatotoxicity KW - Lead KW - Liver KW - Oxidative stress KW - Rats SP - 42 EP - 50 JF - Redox report : communications in free radical research JO - Redox Rep. VL - 22 IS - 1 N2 - OBJECTIVES: Liver is considered a target organ affected by lead toxicity. Oxidative stress is among the mechanisms involved in liver damage. Here we investigated the effects of the natural alkaloid berberine on oxidative stress and hepatotoxicity induced by lead in rats. METHODS: Animals received an aqueous solution of lead acetate (500 mg Pb/l in the drinking water) and/or daily oral gavage of berberine (50 mg/kg) for 8 weeks. Rats were then weighed and used for the biochemical, molecular, and histological evaluations. RESULTS: Lead-induced oxidative stress, shown by increasing lipid peroxidation along with a concomitant decrease in hepatic levels of thiol groups, total antioxidant capacity, the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase, and reduced versus oxidized glutathione ratio. Berberine corrected all the disturbances in oxidative stress markers induced by lead administration. Berberine also prevented the elevated levels of enzymes (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) and the decrease in body weight and albumin. The protective effects of berberine were comparable with silymarin. Furthermore, berberine attenuated liver damage, shown by decreased necrosis and inflammatory cell infiltration. DISCUSSION: Berberine represents a potential therapeutic option against lead-induced hepatotoxicity through inhibiting lipid peroxidation and enhancing antioxidant defenses. CONCLUSION: Berberine exerted protective effects on lead-induced oxidative stress and hepatotoxicity in rats. SN - 1743-2928 UR - https://www.unboundmedicine.com/medline/citation/26871196/Effects_of_isoquinoline_alkaloid_berberine_on_lipid_peroxidation_antioxidant_defense_system_and_liver_damage_induced_by_lead_acetate_in_rats_ L2 - http://www.tandfonline.com/doi/full/10.1080/13510002.2016.1140406 DB - PRIME DP - Unbound Medicine ER -