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Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women.
Gynecol Obstet Invest. 2016; 81(6):512-517.GO

Abstract

BACKGROUND

Endometriosis is a chronic inflammatory disease for which no accurate peripheral diagnostic marker is available. Many cytokines and chemokines have been found altered in the plasma and peritoneal fluid of women with endometriosis compared to healthy controls, but little is known about their diagnostic utility to confirm or discard endometriosis among symptomatic women.

OBJECTIVE

The study aims to assess the diagnostic value of a panel of plasma cytokines and chemokines to detect endometriosis in women undergoing laparoscopy for gynecological complains.

METHODS

We performed a prospective cohort study evaluating simultaneously plasma concentrations of interleukin (IL)-2, IL-4, IL-6, IL-10, MCP-1/CCL2, IP-10/CXCL10 and eotaxin/CCL11 in 75 symptomatic women (chronic pelvic pain, infertility or ovarian cyst) submitted to laparoscopy. Assays were performed by Cytometric Bead Array System. Endometriosis was confirmed by histopathological examination of surgical specimens.

RESULTS

Plasma IL-2, IL-4, IL-6, IL-10, MCP-1/CCL2, IP-10/CXCL10 and eotaxin/CCL11 concentrations were not able to distinguish the women who eventually were diagnosed with endometriosis.

CONCLUSION

Although previously shown to be altered in women with endometriosis compared to healthy women, the tested cytokines and chemokines were not useful to predict the presence of endometriosis among symptomatic women. This finding suggests that inflammatory markers modified by endometriosis may also be altered by other conditions associated with similar symptoms, which limits their use in clinical practice.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26871558

Citation

Rocha, Ana Luiza, et al. "Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women." Gynecologic and Obstetric Investigation, vol. 81, no. 6, 2016, pp. 512-517.
Rocha AL, Vieira EL, Maia LM, et al. Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women. Gynecol Obstet Invest. 2016;81(6):512-517.
Rocha, A. L., Vieira, E. L., Maia, L. M., Teixeira, A. L., & Reis, F. M. (2016). Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women. Gynecologic and Obstetric Investigation, 81(6), 512-517.
Rocha AL, et al. Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women. Gynecol Obstet Invest. 2016;81(6):512-517. PubMed PMID: 26871558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women. AU - Rocha,Ana Luiza, AU - Vieira,Erica L, AU - Maia,Laura M, AU - Teixeira,Antônio Lúcio, AU - Reis,Fernando M, Y1 - 2016/02/13/ PY - 2015/08/31/received PY - 2016/01/11/accepted PY - 2016/2/13/pubmed PY - 2017/4/22/medline PY - 2016/2/13/entrez SP - 512 EP - 517 JF - Gynecologic and obstetric investigation JO - Gynecol. Obstet. Invest. VL - 81 IS - 6 N2 - BACKGROUND: Endometriosis is a chronic inflammatory disease for which no accurate peripheral diagnostic marker is available. Many cytokines and chemokines have been found altered in the plasma and peritoneal fluid of women with endometriosis compared to healthy controls, but little is known about their diagnostic utility to confirm or discard endometriosis among symptomatic women. OBJECTIVE: The study aims to assess the diagnostic value of a panel of plasma cytokines and chemokines to detect endometriosis in women undergoing laparoscopy for gynecological complains. METHODS: We performed a prospective cohort study evaluating simultaneously plasma concentrations of interleukin (IL)-2, IL-4, IL-6, IL-10, MCP-1/CCL2, IP-10/CXCL10 and eotaxin/CCL11 in 75 symptomatic women (chronic pelvic pain, infertility or ovarian cyst) submitted to laparoscopy. Assays were performed by Cytometric Bead Array System. Endometriosis was confirmed by histopathological examination of surgical specimens. RESULTS: Plasma IL-2, IL-4, IL-6, IL-10, MCP-1/CCL2, IP-10/CXCL10 and eotaxin/CCL11 concentrations were not able to distinguish the women who eventually were diagnosed with endometriosis. CONCLUSION: Although previously shown to be altered in women with endometriosis compared to healthy women, the tested cytokines and chemokines were not useful to predict the presence of endometriosis among symptomatic women. This finding suggests that inflammatory markers modified by endometriosis may also be altered by other conditions associated with similar symptoms, which limits their use in clinical practice. SN - 1423-002X UR - https://www.unboundmedicine.com/medline/citation/26871558/Prospective_Evaluation_of_a_Panel_of_Plasma_Cytokines_and_Chemokines_as_Potential_Markers_of_Pelvic_Endometriosis_in_Symptomatic_Women_ L2 - https://www.karger.com?DOI=10.1159/000443956 DB - PRIME DP - Unbound Medicine ER -