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Perinatal vitamin D levels are not associated with later risk of developing pediatric-onset inflammatory bowel disease: a Danish case-cohort study.
Scand J Gastroenterol 2016; 51(8):927-33SJ

Abstract

Objective Basic and epidemiologic studies on inflammatory bowel disease (IBD) have suggested an association between vitamin D and IBD risk. Though, the literature on IBD - especially pediatric-onset IBD - and vitamin D is still in its cradle. We therefore wanted to examine if levels of 25(OH)D at birth were associated with increased risk of developing pediatric-onset IBD. Material and methods A case-cohort study composed of cases diagnosed with Crohn's disease, ulcerative colitis or indeterminate/unclassified colitis and healthy controls. Cases and controls were matched on date of birth and were born in the period 1981-2004. Cases were diagnosed before the age of 18 years. The concentration of 25(OH)D was assessed from neonatal dried blood spots using a highly sensitive liquid chromatography tandem mass spectrometry. Odds ratios (OR) were calculated using conditional logistic regression and two-way ANOVA were used to test for season and birth year 25(OH)D variations. A total of 384 matched pairs were included in the statistical analyses. Results No significant association were found between levels of 25(OH)D and IBD risk in the adjusted model (OR [95% CI] (per 25 nmol/L increase), 1.12 [0.88; 1.42], p = 0.35). 25(OH)D levels were found to fluctuate significantly with season (p < 0.001) and year (p < 0.001). Median/Q1-Q3 values for 25(OH)D were 27.1/16.5-39.5 nmol/L for cases and 25.7/16.1-39.4 nmol/L for controls. Conclusion Our study do not suggest that a window of vulnerability exist around time of birth in regards to 25(OH)D levels and later pediatric-onset IBD risk.

Authors+Show Affiliations

a Department of Paediatrics, Copenhagen Diabetes Research Center (CPH-DIRECT) , Herlev University Hospital , Herlev , Denmark ; b Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark ;c Department of Paediatrics , Hvidovre University Hospital , Hvidovre , Denmark ;d Department of Congenital Disorders , Statens Serum Institute , Copenhagen S , Denmark ;d Department of Congenital Disorders , Statens Serum Institute , Copenhagen S , Denmark ;e National Institute of Public Health , University of Southern Denmark , Copenhagen K , Denmark ;f Department of Public Health, Section of Biostatistics , University of Copenhagen , Copenhagen K , Denmark ;g Department of Nutrition , Harvard T.H. Chan School of Public Health , Boston , MA , USA.a Department of Paediatrics, Copenhagen Diabetes Research Center (CPH-DIRECT) , Herlev University Hospital , Herlev , Denmark ;

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26872831

Citation

Thorsen, Steffen U., et al. "Perinatal Vitamin D Levels Are Not Associated With Later Risk of Developing Pediatric-onset Inflammatory Bowel Disease: a Danish Case-cohort Study." Scandinavian Journal of Gastroenterology, vol. 51, no. 8, 2016, pp. 927-33.
Thorsen SU, Jakobsen C, Cohen A, et al. Perinatal vitamin D levels are not associated with later risk of developing pediatric-onset inflammatory bowel disease: a Danish case-cohort study. Scand J Gastroenterol. 2016;51(8):927-33.
Thorsen, S. U., Jakobsen, C., Cohen, A., Lundqvist, M., Thygesen, L. C., Pipper, C., ... Svensson, J. (2016). Perinatal vitamin D levels are not associated with later risk of developing pediatric-onset inflammatory bowel disease: a Danish case-cohort study. Scandinavian Journal of Gastroenterology, 51(8), pp. 927-33. doi:10.3109/00365521.2016.1144218.
Thorsen SU, et al. Perinatal Vitamin D Levels Are Not Associated With Later Risk of Developing Pediatric-onset Inflammatory Bowel Disease: a Danish Case-cohort Study. Scand J Gastroenterol. 2016;51(8):927-33. PubMed PMID: 26872831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal vitamin D levels are not associated with later risk of developing pediatric-onset inflammatory bowel disease: a Danish case-cohort study. AU - Thorsen,Steffen U, AU - Jakobsen,Christian, AU - Cohen,Arieh, AU - Lundqvist,Marika, AU - Thygesen,Lau C, AU - Pipper,Christian, AU - Ascherio,Alberto, AU - Svensson,Jannet, Y1 - 2016/02/12/ PY - 2016/2/14/entrez PY - 2016/2/14/pubmed PY - 2017/4/25/medline KW - Autoimmunity KW - epidemiology KW - inflammatory bowel diseases KW - vitamin D SP - 927 EP - 33 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 51 IS - 8 N2 - Objective Basic and epidemiologic studies on inflammatory bowel disease (IBD) have suggested an association between vitamin D and IBD risk. Though, the literature on IBD - especially pediatric-onset IBD - and vitamin D is still in its cradle. We therefore wanted to examine if levels of 25(OH)D at birth were associated with increased risk of developing pediatric-onset IBD. Material and methods A case-cohort study composed of cases diagnosed with Crohn's disease, ulcerative colitis or indeterminate/unclassified colitis and healthy controls. Cases and controls were matched on date of birth and were born in the period 1981-2004. Cases were diagnosed before the age of 18 years. The concentration of 25(OH)D was assessed from neonatal dried blood spots using a highly sensitive liquid chromatography tandem mass spectrometry. Odds ratios (OR) were calculated using conditional logistic regression and two-way ANOVA were used to test for season and birth year 25(OH)D variations. A total of 384 matched pairs were included in the statistical analyses. Results No significant association were found between levels of 25(OH)D and IBD risk in the adjusted model (OR [95% CI] (per 25 nmol/L increase), 1.12 [0.88; 1.42], p = 0.35). 25(OH)D levels were found to fluctuate significantly with season (p < 0.001) and year (p < 0.001). Median/Q1-Q3 values for 25(OH)D were 27.1/16.5-39.5 nmol/L for cases and 25.7/16.1-39.4 nmol/L for controls. Conclusion Our study do not suggest that a window of vulnerability exist around time of birth in regards to 25(OH)D levels and later pediatric-onset IBD risk. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/26872831/Perinatal_vitamin_D_levels_are_not_associated_with_later_risk_of_developing_pediatric_onset_inflammatory_bowel_disease:_a_Danish_case_cohort_study_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365521.2016.1144218 DB - PRIME DP - Unbound Medicine ER -