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Association between dietary carbohydrate intake, glycemic index and glycemic load, and risk of gastric cancer.
Eur J Nutr. 2017 Apr; 56(3):1169-1177.EJ

Abstract

PURPOSE

The association between dietary carbohydrate intake, glycemic index (GI) and glycemic load (GL), and risk of gastric cancer (GC) has been investigated by many studies. However, the results of these studies were controversial. The aim of our study was to systematically assess this issue.

METHODS

PUBMED and EMBASE were searched up to March 2015, and either a fixed- or a random-effects model was adopted to estimate overall relative risks (RRs). Dose-response, meta-regression, subgroup, and publication bias analyses were applied.

RESULTS

Twenty-six studies with approximately 540,000 participants were finally included in this meta-analysis. High level of dietary carbohydrate intake (pooled RR 1.17, 95 % CI 0.91-1.50), GI (pooled RR 1.17, 95 % CI 0.80-1.69), and GL (pooled RR 1.06, 95 % CI 0.90-1.26) were all nonsignificantly associated with incidence of GC. In addition, no significant dose-response relationship was observed between carbohydrate intake, GI and GL, and the risk of GC. However, further subgroup analyses based on gender and geographic region suggested a significant association between higher carbohydrate intake (pooled RR 1.52, 95 % CI 1.10-2.08), GL (pooled RR 1.41, 95 % CI 1.04-1.92), and GC risk in males subgroup, and between higher carbohydrate intake (pooled RR 1.69, 95 % CI 1.36-2.09) and GC risk in Asian studies.

CONCLUSIONS

No significant association was found between dietary carbohydrate intake, GI and GL, and risk of GC. However, significantly positive association was observed in the males subgroup and Asian studies.

Authors+Show Affiliations

Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, 310058, Zhejiang, China. Department of Oncology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, 310009, Zhejiang, China.Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, 310058, Zhejiang, China. georgewuer@126.com. Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, 310058, Zhejiang, China. georgewuer@126.com.Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, 310058, Zhejiang, China. Department of Oncology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, 310009, Zhejiang, China.Department of Oncology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, 310009, Zhejiang, China.Jinhua Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, 321000, Zhejiang, China.Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, 310058, Zhejiang, China. dxia@zju.edu.cn. Zhejiang University School of Public Health, Hangzhou, 310058, China. dxia@zju.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

26873099

Citation

Ye, Yao, et al. "Association Between Dietary Carbohydrate Intake, Glycemic Index and Glycemic Load, and Risk of Gastric Cancer." European Journal of Nutrition, vol. 56, no. 3, 2017, pp. 1169-1177.
Ye Y, Wu Y, Xu J, et al. Association between dietary carbohydrate intake, glycemic index and glycemic load, and risk of gastric cancer. Eur J Nutr. 2017;56(3):1169-1177.
Ye, Y., Wu, Y., Xu, J., Ding, K., Shan, X., & Xia, D. (2017). Association between dietary carbohydrate intake, glycemic index and glycemic load, and risk of gastric cancer. European Journal of Nutrition, 56(3), 1169-1177. https://doi.org/10.1007/s00394-016-1166-4
Ye Y, et al. Association Between Dietary Carbohydrate Intake, Glycemic Index and Glycemic Load, and Risk of Gastric Cancer. Eur J Nutr. 2017;56(3):1169-1177. PubMed PMID: 26873099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between dietary carbohydrate intake, glycemic index and glycemic load, and risk of gastric cancer. AU - Ye,Yao, AU - Wu,Yihua, AU - Xu,Jinming, AU - Ding,Kefeng, AU - Shan,Xiaoyun, AU - Xia,Dajing, Y1 - 2016/02/12/ PY - 2015/08/29/received PY - 2016/01/22/accepted PY - 2016/2/14/pubmed PY - 2017/8/24/medline PY - 2016/2/14/entrez KW - Carbohydrate intake KW - Gastric cancer KW - Glycemic index KW - Glycemic load SP - 1169 EP - 1177 JF - European journal of nutrition JO - Eur J Nutr VL - 56 IS - 3 N2 - PURPOSE: The association between dietary carbohydrate intake, glycemic index (GI) and glycemic load (GL), and risk of gastric cancer (GC) has been investigated by many studies. However, the results of these studies were controversial. The aim of our study was to systematically assess this issue. METHODS: PUBMED and EMBASE were searched up to March 2015, and either a fixed- or a random-effects model was adopted to estimate overall relative risks (RRs). Dose-response, meta-regression, subgroup, and publication bias analyses were applied. RESULTS: Twenty-six studies with approximately 540,000 participants were finally included in this meta-analysis. High level of dietary carbohydrate intake (pooled RR 1.17, 95 % CI 0.91-1.50), GI (pooled RR 1.17, 95 % CI 0.80-1.69), and GL (pooled RR 1.06, 95 % CI 0.90-1.26) were all nonsignificantly associated with incidence of GC. In addition, no significant dose-response relationship was observed between carbohydrate intake, GI and GL, and the risk of GC. However, further subgroup analyses based on gender and geographic region suggested a significant association between higher carbohydrate intake (pooled RR 1.52, 95 % CI 1.10-2.08), GL (pooled RR 1.41, 95 % CI 1.04-1.92), and GC risk in males subgroup, and between higher carbohydrate intake (pooled RR 1.69, 95 % CI 1.36-2.09) and GC risk in Asian studies. CONCLUSIONS: No significant association was found between dietary carbohydrate intake, GI and GL, and risk of GC. However, significantly positive association was observed in the males subgroup and Asian studies. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/26873099/Association_between_dietary_carbohydrate_intake_glycemic_index_and_glycemic_load_and_risk_of_gastric_cancer_ L2 - https://dx.doi.org/10.1007/s00394-016-1166-4 DB - PRIME DP - Unbound Medicine ER -