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Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization.
J Allergy Clin Immunol. 2016 Apr; 137(4):1063-1070.e2.JA

Abstract

BACKGROUND

The role of early-life vitamin D in childhood allergy is controversial.

OBJECTIVE

We sought to assess vitamin D exposure in early life by multiple modalities and ascertain its association with childhood allergic rhinitis and allergic sensitization.

METHODS

One thousand two hundred forty-eight mother-child pairs from a US prebirth cohort unselected for any disease were studied. Vitamin D exposure was assessed by measures of maternal intake during the first and second trimesters of pregnancy and serum 25-hydroxyvitamin D (25[OH]D) levels in mothers during pregnancy, cord blood, and children at school age (median age, 7.7 years; interquartile range, 1.0 years). Tests for associations between vitamin D exposure with ever allergic rhinitis, serum total IgE level, and allergen sensitization at school age were conducted.

RESULTS

The correlations between maternal intake of vitamin D during pregnancy and serum 25(OH)D levels in pregnant mothers, cord blood, and children at school age were weak to moderate (r = -0.03 to 0.53). Each 100 IU/d of food-based vitamin D intake during the first and second trimesters (equivalent to the amount of vitamin D in an 8-ounce serving of milk) was associated with 21% and 20% reduced odds of ever allergic rhinitis at school age (odds ratios of 0.79 [95% CI, 0.67-0.92] and 0.80 [95% CI, 0.68-0.93]), respectively. There were no associations between maternal supplemental vitamin D intake or serum 25(OH)D levels at any time point with ever allergic rhinitis. There were no associations between any vitamin D exposure and serum total IgE level or allergen sensitization at school age.

CONCLUSIONS

Inclusion of foods containing vitamin D in maternal diets during pregnancy may have beneficial effects on childhood allergic rhinitis.

Authors+Show Affiliations

Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: supinda@post.harvard.edu.Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Mass; Harvard Medical School, Boston, Mass.Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, Va.Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, Va.Harvard Medical School, Boston, Mass; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.Harvard Medical School, Boston, Mass; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Mass.Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Mass; Harvard Medical School, Boston, Mass.Harvard Medical School, Boston, Mass; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.Harvard Medical School, Boston, Mass; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26874366

Citation

Bunyavanich, Supinda, et al. "Prenatal, Perinatal, and Childhood Vitamin D Exposure and Their Association With Childhood Allergic Rhinitis and Allergic Sensitization." The Journal of Allergy and Clinical Immunology, vol. 137, no. 4, 2016, pp. 1063-1070.e2.
Bunyavanich S, Rifas-Shiman SL, Platts-Mills TA, et al. Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. J Allergy Clin Immunol. 2016;137(4):1063-1070.e2.
Bunyavanich, S., Rifas-Shiman, S. L., Platts-Mills, T. A., Workman, L., Sordillo, J. E., Camargo, C. A., Gillman, M. W., Gold, D. R., & Litonjua, A. A. (2016). Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. The Journal of Allergy and Clinical Immunology, 137(4), 1063-e2. https://doi.org/10.1016/j.jaci.2015.11.031
Bunyavanich S, et al. Prenatal, Perinatal, and Childhood Vitamin D Exposure and Their Association With Childhood Allergic Rhinitis and Allergic Sensitization. J Allergy Clin Immunol. 2016;137(4):1063-1070.e2. PubMed PMID: 26874366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. AU - Bunyavanich,Supinda, AU - Rifas-Shiman,Sheryl L, AU - Platts-Mills,Thomas A, AU - Workman,Lisa, AU - Sordillo,Joanne E, AU - Camargo,Carlos A,Jr AU - Gillman,Matthew W, AU - Gold,Diane R, AU - Litonjua,Augusto A, Y1 - 2016/02/10/ PY - 2015/07/14/received PY - 2015/10/30/revised PY - 2015/11/20/accepted PY - 2016/2/15/entrez PY - 2016/2/15/pubmed PY - 2016/8/23/medline KW - Allergic rhinitis KW - allergy KW - atopy KW - childhood KW - food KW - perinatal KW - prenatal KW - sensitization KW - supplement KW - vitamin D SP - 1063 EP - 1070.e2 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 137 IS - 4 N2 - BACKGROUND: The role of early-life vitamin D in childhood allergy is controversial. OBJECTIVE: We sought to assess vitamin D exposure in early life by multiple modalities and ascertain its association with childhood allergic rhinitis and allergic sensitization. METHODS: One thousand two hundred forty-eight mother-child pairs from a US prebirth cohort unselected for any disease were studied. Vitamin D exposure was assessed by measures of maternal intake during the first and second trimesters of pregnancy and serum 25-hydroxyvitamin D (25[OH]D) levels in mothers during pregnancy, cord blood, and children at school age (median age, 7.7 years; interquartile range, 1.0 years). Tests for associations between vitamin D exposure with ever allergic rhinitis, serum total IgE level, and allergen sensitization at school age were conducted. RESULTS: The correlations between maternal intake of vitamin D during pregnancy and serum 25(OH)D levels in pregnant mothers, cord blood, and children at school age were weak to moderate (r = -0.03 to 0.53). Each 100 IU/d of food-based vitamin D intake during the first and second trimesters (equivalent to the amount of vitamin D in an 8-ounce serving of milk) was associated with 21% and 20% reduced odds of ever allergic rhinitis at school age (odds ratios of 0.79 [95% CI, 0.67-0.92] and 0.80 [95% CI, 0.68-0.93]), respectively. There were no associations between maternal supplemental vitamin D intake or serum 25(OH)D levels at any time point with ever allergic rhinitis. There were no associations between any vitamin D exposure and serum total IgE level or allergen sensitization at school age. CONCLUSIONS: Inclusion of foods containing vitamin D in maternal diets during pregnancy may have beneficial effects on childhood allergic rhinitis. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/26874366/Prenatal_perinatal_and_childhood_vitamin_D_exposure_and_their_association_with_childhood_allergic_rhinitis_and_allergic_sensitization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(16)00035-X DB - PRIME DP - Unbound Medicine ER -