Tags

Type your tag names separated by a space and hit enter

Application of biotic ligand and toxicokinetic-toxicodynamic modeling to predict the accumulation and toxicity of metal mixtures to zebrafish larvae.
Environ Pollut. 2016 Jun; 213:16-29.EP

Abstract

Predicting the accumulation and toxicity of mixtures of metals to aquatic organisms is a key challenge in ecotoxicological studies. In this study, the accumulation and toxicity of mixed essential (Cu) and nonessential (Cd and Pb) metals in zebrafish larvae exposed to a binary mixture of these elements at environmentally relevant concentrations were predicted using a refined toxicokinetic (TK)-toxicodynamic (TD) model aided with biotic ligand model (BLM) and toxic equivalent factor (TEF) approach. Competitive inhibition and non-competitive interaction/inhibition were observed in bio-uptake. Both Pb and Cd behaved as competitive inhibitors of Cu uptake at high Cu concentrations (>0.1 μM). By contrast, Cu uptake was independent of Cd or Pb when the Cu concentrations were below 10(-7) M. Furthermore, low concentrations of Cu had an adiaphorous effect on Cd or Pb uptake. Cd uptake was inhibited by Pb, and the Pb uptake rates consistently decreased in the presence of Cd. The accumulation processes of Cd-Pb, Cu-Cd, and Cu-Pb were accurately predicted by the BLM-aided TK models. The traditional TD model could successfully predict the toxicity of Cd-Pb mixtures, but not those of Cu-Cd or Cu-Pb mixtures. The revised TD model, which considered the possible different killing rates (Kk) above or below the threshold, offered better prediction for the toxicity of Cu-Cd or Cu-Pb mixtures. The overall findings may be of key significance in understanding and predicting metal uptake, accumulation, and toxicity in binary or multiple metal exposure scenarios.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Gao Y
Key Laboratory of Pollution Process and Environmental Criteria of Ministry of Education and Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China.
Feng J
Key Laboratory of Pollution Process and Environmental Criteria of Ministry of Education and Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China. Electronic address: fengjf@nankai.edu.cn.
Han F
Bureau of Hydrology and Water Resources of Henan Province, Zhenzhou, China.
Zhu L
Key Laboratory of Pollution Process and Environmental Criteria of Ministry of Education and Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China. Electronic address: zhulin@nankai.edu.cn.

MeSH

AnimalsCadmiumCopperEcotoxicologyIon TransportLarvaLeadLigandsModels, BiologicalToxicokineticsZebrafish

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26874871

Citation

Gao, Yongfei, et al. "Application of Biotic Ligand and Toxicokinetic-toxicodynamic Modeling to Predict the Accumulation and Toxicity of Metal Mixtures to Zebrafish Larvae." Environmental Pollution (Barking, Essex : 1987), vol. 213, 2016, pp. 16-29.
Gao Y, Feng J, Han F, et al. Application of biotic ligand and toxicokinetic-toxicodynamic modeling to predict the accumulation and toxicity of metal mixtures to zebrafish larvae. Environ Pollut. 2016;213:16-29.
Gao, Y., Feng, J., Han, F., & Zhu, L. (2016). Application of biotic ligand and toxicokinetic-toxicodynamic modeling to predict the accumulation and toxicity of metal mixtures to zebrafish larvae. Environmental Pollution (Barking, Essex : 1987), 213, 16-29. https://doi.org/10.1016/j.envpol.2016.01.073
Gao Y, et al. Application of Biotic Ligand and Toxicokinetic-toxicodynamic Modeling to Predict the Accumulation and Toxicity of Metal Mixtures to Zebrafish Larvae. Environ Pollut. 2016;213:16-29. PubMed PMID: 26874871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Application of biotic ligand and toxicokinetic-toxicodynamic modeling to predict the accumulation and toxicity of metal mixtures to zebrafish larvae. AU - Gao,Yongfei, AU - Feng,Jianfeng, AU - Han,Feng, AU - Zhu,Lin, Y1 - 2016/02/11/ PY - 2015/10/15/received PY - 2016/01/21/revised PY - 2016/01/25/accepted PY - 2016/2/15/entrez PY - 2016/2/15/pubmed PY - 2017/1/10/medline KW - Acute toxicity KW - BL KW - BLM KW - Bioaccumulation KW - Biotic ligand KW - CBR KW - Metal mixtures KW - TD model KW - TEF KW - TEQ KW - TK model KW - TK-TD model KW - TK1 KW - TK2 KW - Toxicokinetic–toxicodynamic (TK-TD) model KW - biotic ligand KW - biotic ligand model KW - the dynamic Critical Body Residue KW - the toxic equivalent quantity KW - toxic equivalent factor KW - toxicodynamic model KW - toxicokinetic model KW - toxicokinetic model 1 KW - toxicokinetic model 2 KW - toxicokinetic–toxicodynamic model SP - 16 EP - 29 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 213 N2 - Predicting the accumulation and toxicity of mixtures of metals to aquatic organisms is a key challenge in ecotoxicological studies. In this study, the accumulation and toxicity of mixed essential (Cu) and nonessential (Cd and Pb) metals in zebrafish larvae exposed to a binary mixture of these elements at environmentally relevant concentrations were predicted using a refined toxicokinetic (TK)-toxicodynamic (TD) model aided with biotic ligand model (BLM) and toxic equivalent factor (TEF) approach. Competitive inhibition and non-competitive interaction/inhibition were observed in bio-uptake. Both Pb and Cd behaved as competitive inhibitors of Cu uptake at high Cu concentrations (>0.1 μM). By contrast, Cu uptake was independent of Cd or Pb when the Cu concentrations were below 10(-7) M. Furthermore, low concentrations of Cu had an adiaphorous effect on Cd or Pb uptake. Cd uptake was inhibited by Pb, and the Pb uptake rates consistently decreased in the presence of Cd. The accumulation processes of Cd-Pb, Cu-Cd, and Cu-Pb were accurately predicted by the BLM-aided TK models. The traditional TD model could successfully predict the toxicity of Cd-Pb mixtures, but not those of Cu-Cd or Cu-Pb mixtures. The revised TD model, which considered the possible different killing rates (Kk) above or below the threshold, offered better prediction for the toxicity of Cu-Cd or Cu-Pb mixtures. The overall findings may be of key significance in understanding and predicting metal uptake, accumulation, and toxicity in binary or multiple metal exposure scenarios. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/26874871/Application_of_biotic_ligand_and_toxicokinetic_toxicodynamic_modeling_to_predict_the_accumulation_and_toxicity_of_metal_mixtures_to_zebrafish_larvae_ DB - PRIME DP - Unbound Medicine ER -