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Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: A pooled analysis of two prospective studies.
Clin Nutr 2017; 36(2):537-541CN

Abstract

BACKGROUND & AIMS

Whether high intakes of fish and long-chain omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF) remains uncertain. Thus, we aimed to evaluate the associations of total fish, types of fish, and omega-3 PUFA intake with AF incidence in a large prospective study.

METHODS

We used data from the Cohort of Swedish Men and the Swedish Mammography Cohort to examine the associations of fish consumption and long-chain omega-3 PUFA intake with AF incidence. At baseline, information on fish and omega-3 PUFA intakes was available from 72,984 men and women, aged 45-83 years, without cardiac disease. Cases of AF were identified through linkage with the Swedish National Patient Register. Multivariable-adjusted relative risks were estimated with the use of Cox proportional hazards models.

RESULTS

Over a follow-up period of 12 years, 6095 participants (3595 men and 2500 women) developed AF. Intakes of total fish, fatty fish (herring/mackerel and salmon/whitefish/char), and long-chain omega-3 PUFAs were not associated with AF incidence after adjustment for other risk factors. However, high consumption of lean fish (cod/saithe/fish fingers) was associated with a lower risk; multivariable relative risk of AF for ≥3 servings/week compared with never consumption was 0.79 (95% confidence interval, 0.65-0.95).

CONCLUSIONS

These findings do not support a beneficial association of fatty fish or omega-3 PUFA intake with incident AF. The association between lean fish consumption and AF risk warrants further investigation.

Authors+Show Affiliations

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: susanna.larsson@ki.se.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26875446

Citation

Larsson, Susanna C., and Alicja Wolk. "Fish, Long-chain Omega-3 Polyunsaturated Fatty Acid Intake and Incidence of Atrial Fibrillation: a Pooled Analysis of Two Prospective Studies." Clinical Nutrition (Edinburgh, Scotland), vol. 36, no. 2, 2017, pp. 537-541.
Larsson SC, Wolk A. Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: A pooled analysis of two prospective studies. Clin Nutr. 2017;36(2):537-541.
Larsson, S. C., & Wolk, A. (2017). Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: A pooled analysis of two prospective studies. Clinical Nutrition (Edinburgh, Scotland), 36(2), pp. 537-541. doi:10.1016/j.clnu.2016.01.019.
Larsson SC, Wolk A. Fish, Long-chain Omega-3 Polyunsaturated Fatty Acid Intake and Incidence of Atrial Fibrillation: a Pooled Analysis of Two Prospective Studies. Clin Nutr. 2017;36(2):537-541. PubMed PMID: 26875446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: A pooled analysis of two prospective studies. AU - Larsson,Susanna C, AU - Wolk,Alicja, Y1 - 2016/02/03/ PY - 2015/08/17/received PY - 2016/01/13/revised PY - 2016/01/24/accepted PY - 2016/2/16/pubmed PY - 2018/3/1/medline PY - 2016/2/16/entrez KW - Atrial fibrillation KW - Diet KW - Fish KW - Polyunsaturated fatty acids KW - Prospective studies SP - 537 EP - 541 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 36 IS - 2 N2 - BACKGROUND & AIMS: Whether high intakes of fish and long-chain omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF) remains uncertain. Thus, we aimed to evaluate the associations of total fish, types of fish, and omega-3 PUFA intake with AF incidence in a large prospective study. METHODS: We used data from the Cohort of Swedish Men and the Swedish Mammography Cohort to examine the associations of fish consumption and long-chain omega-3 PUFA intake with AF incidence. At baseline, information on fish and omega-3 PUFA intakes was available from 72,984 men and women, aged 45-83 years, without cardiac disease. Cases of AF were identified through linkage with the Swedish National Patient Register. Multivariable-adjusted relative risks were estimated with the use of Cox proportional hazards models. RESULTS: Over a follow-up period of 12 years, 6095 participants (3595 men and 2500 women) developed AF. Intakes of total fish, fatty fish (herring/mackerel and salmon/whitefish/char), and long-chain omega-3 PUFAs were not associated with AF incidence after adjustment for other risk factors. However, high consumption of lean fish (cod/saithe/fish fingers) was associated with a lower risk; multivariable relative risk of AF for ≥3 servings/week compared with never consumption was 0.79 (95% confidence interval, 0.65-0.95). CONCLUSIONS: These findings do not support a beneficial association of fatty fish or omega-3 PUFA intake with incident AF. The association between lean fish consumption and AF risk warrants further investigation. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/26875446/Fish_long_chain_omega_3_polyunsaturated_fatty_acid_intake_and_incidence_of_atrial_fibrillation:_A_pooled_analysis_of_two_prospective_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(16)00046-7 DB - PRIME DP - Unbound Medicine ER -