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[Cytomegalovirus infection after haploidentical stem cell transplantation may reduce relapse risk in leukemia].
Zhonghua Nei Ke Za Zhi. 2016 Feb; 55(2):107-10.ZN

Abstract

OBJECTIVE

To analyze the relationship between cytomegalovirus (CMV) reactivation and leukemia relapse after haploidentical hematopoietic stem cell transplantation (haplo-HSCT).

METHODS

A total of 61 patients diagnosed as hematological malignancies undergoing haplo-HSCT were analyzed retrospectively in our center.

RESULTS

In the cohort, 36 patients had CMV reactivation after haplo-HSCT. The 100-day cumulative incidence of CMV reactivation was 59%. Compared with that in patients without CMV reactivation after transplantation, the incidence of leukemia relapse was lower in patients with CMV reactivation (16.9% vs 40.0%, P=0.034). The correlation of CMV reactivation and decreased relapse rate was only found in patients with acute myeloid leukemia (P=0.019). In multivariate analysis, relapsed disease status before transplant was a significant negative predictor of overall survival (OS) and relapse after transplant (RR was 2.866 and 3.331 respectively). CMV reactivation after transplant had a protective effect on disease relapse (RR=0.300, P=0.047).

CONCLUSIONS

The rate of CMV reactivation after haplo-HSCT is high. CMV reactivation may reduce risk of relapse in patients diagnosed as acute myeloid leukemia undergoing haplo-HSCT. However, CMV reactivation is one of the important predictors of non-relapse death after transplant, active anti-viral treatment is still needed.

Authors+Show Affiliations

Department of Hematology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

26875578

Citation

Lin, Xia, et al. "[Cytomegalovirus Infection After Haploidentical Stem Cell Transplantation May Reduce Relapse Risk in Leukemia]." Zhonghua Nei Ke Za Zhi, vol. 55, no. 2, 2016, pp. 107-10.
Lin X, Ou Y, Long H, et al. [Cytomegalovirus infection after haploidentical stem cell transplantation may reduce relapse risk in leukemia]. Zhonghua Nei Ke Za Zhi. 2016;55(2):107-10.
Lin, X., Ou, Y., Long, H., Huang, Y., Song, C., Lu, Z., Guo, K., Wu, B., & Xu, J. (2016). [Cytomegalovirus infection after haploidentical stem cell transplantation may reduce relapse risk in leukemia]. Zhonghua Nei Ke Za Zhi, 55(2), 107-10. https://doi.org/10.3760/cma.j.issn.0578-1426.2016.02.008
Lin X, et al. [Cytomegalovirus Infection After Haploidentical Stem Cell Transplantation May Reduce Relapse Risk in Leukemia]. Zhonghua Nei Ke Za Zhi. 2016;55(2):107-10. PubMed PMID: 26875578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cytomegalovirus infection after haploidentical stem cell transplantation may reduce relapse risk in leukemia]. AU - Lin,Xia, AU - Ou,Ying, AU - Long,Hui, AU - Huang,Yuxian, AU - Song,Chaoyang, AU - Lu,Zhigang, AU - Guo,Kunyuan, AU - Wu,Bingyi, AU - Xu,Jianhui, PY - 2016/2/16/entrez PY - 2016/2/16/pubmed PY - 2016/9/16/medline SP - 107 EP - 10 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 55 IS - 2 N2 - OBJECTIVE: To analyze the relationship between cytomegalovirus (CMV) reactivation and leukemia relapse after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). METHODS: A total of 61 patients diagnosed as hematological malignancies undergoing haplo-HSCT were analyzed retrospectively in our center. RESULTS: In the cohort, 36 patients had CMV reactivation after haplo-HSCT. The 100-day cumulative incidence of CMV reactivation was 59%. Compared with that in patients without CMV reactivation after transplantation, the incidence of leukemia relapse was lower in patients with CMV reactivation (16.9% vs 40.0%, P=0.034). The correlation of CMV reactivation and decreased relapse rate was only found in patients with acute myeloid leukemia (P=0.019). In multivariate analysis, relapsed disease status before transplant was a significant negative predictor of overall survival (OS) and relapse after transplant (RR was 2.866 and 3.331 respectively). CMV reactivation after transplant had a protective effect on disease relapse (RR=0.300, P=0.047). CONCLUSIONS: The rate of CMV reactivation after haplo-HSCT is high. CMV reactivation may reduce risk of relapse in patients diagnosed as acute myeloid leukemia undergoing haplo-HSCT. However, CMV reactivation is one of the important predictors of non-relapse death after transplant, active anti-viral treatment is still needed. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/26875578/[Cytomegalovirus_infection_after_haploidentical_stem_cell_transplantation_may_reduce_relapse_risk_in_leukemia]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0578-1426&year=2016&vol=55&issue=2&fpage=107 DB - PRIME DP - Unbound Medicine ER -