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The overlap of upper functional gastrointestinal disorders with irritable bowel syndrome in Chinese outpatients: A multicenter study.
J Gastroenterol Hepatol. 2016 Sep; 31(9):1584-93.JG

Abstract

BACKGROUND AND AIM

Irritable bowel syndrome (IBS) is a common functional bowel disease, and the overlap with upper functional gastrointestinal disorders (FGIDs) is popular. However, the coexistent upper GI symptom profiles, upper FGID spectra, and related risk factors among IBS subjects remain unclear in mainland of China.

METHODS

Consecutive patients from the outpatient gastroenterology clinics of three tertiary hospitals in China were enrolled in this multicenter study. All upper GI symptoms occurring at least once a week in the last 3 months were recorded. Diagnostic criteria of functional esophageal, gastroduodenal disorders and IBS were based on Rome III criteria. Risk factors were assessed using a multivariate logistic regression model.

RESULTS

Of the 8906 consecutive patients, 751 patients met Rome III criteria for IBS and 735 IBS patients participated in the interview. Postprandial fullness (30.6%), belching (27.1%), and regurgitation (21.8%) were the three most prevalent upper GI symptoms in IBS. Functional dyspepsia (FD, 36.7%), belching disorders (27.1%), and functional heartburn (16.3%) were the three most frequent upper FGID in IBS patients. Female sex, divorced or widowed versus married status, defecation straining, reduced bowel movement, mixed IBS, abdominal distention, mild abdominal pain, moderate discomfort were positively associated with IBS-FD overlap. Female sex, drinking, moderate discomfort, and mild to moderate distension were independent risk factors for IBS-belching disorder overlap.

CONCLUSIONS

The study provides detailed overlap spectra of upper FGID with IBS. Mixed IBS is an important risk factor for IBS-FD overlap, which deserved more concern.

Authors+Show Affiliations

Department of Gastroenterology, Bethune International Peace Hospital, Shijiazhuang, China.Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China. sunny888@medmail.com.cn.Department of Gastroenterology, Naval General Hospital, Beijing, China.Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.Department of Gastroenterology and Hepatology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.Department of Epidemiology and Statistics, Hebei Medical University, Shijiazhuang, China.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

26875585

Citation

Yao, Xin, et al. "The Overlap of Upper Functional Gastrointestinal Disorders With Irritable Bowel Syndrome in Chinese Outpatients: a Multicenter Study." Journal of Gastroenterology and Hepatology, vol. 31, no. 9, 2016, pp. 1584-93.
Yao X, Yang YS, Cui LH, et al. The overlap of upper functional gastrointestinal disorders with irritable bowel syndrome in Chinese outpatients: A multicenter study. J Gastroenterol Hepatol. 2016;31(9):1584-93.
Yao, X., Yang, Y. S., Cui, L. H., Sun, G., Peng, L. H., Wang, W. F., Hyder, Q., & Zhang, X. L. (2016). The overlap of upper functional gastrointestinal disorders with irritable bowel syndrome in Chinese outpatients: A multicenter study. Journal of Gastroenterology and Hepatology, 31(9), 1584-93. https://doi.org/10.1111/jgh.13317
Yao X, et al. The Overlap of Upper Functional Gastrointestinal Disorders With Irritable Bowel Syndrome in Chinese Outpatients: a Multicenter Study. J Gastroenterol Hepatol. 2016;31(9):1584-93. PubMed PMID: 26875585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The overlap of upper functional gastrointestinal disorders with irritable bowel syndrome in Chinese outpatients: A multicenter study. AU - Yao,Xin, AU - Yang,Yun Sheng, AU - Cui,Li Hong, AU - Sun,Gang, AU - Peng,Li Hua, AU - Wang,Wei Feng, AU - Hyder,Qurratulain, AU - Zhang,Xiao Lin, PY - 2015/12/08/received PY - 2016/02/06/revised PY - 2016/02/08/accepted PY - 2016/2/16/entrez PY - 2016/2/16/pubmed PY - 2019/3/21/medline KW - belching KW - dyspepsia KW - heartburn KW - irritable bowel syndrome SP - 1584 EP - 93 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 31 IS - 9 N2 - BACKGROUND AND AIM: Irritable bowel syndrome (IBS) is a common functional bowel disease, and the overlap with upper functional gastrointestinal disorders (FGIDs) is popular. However, the coexistent upper GI symptom profiles, upper FGID spectra, and related risk factors among IBS subjects remain unclear in mainland of China. METHODS: Consecutive patients from the outpatient gastroenterology clinics of three tertiary hospitals in China were enrolled in this multicenter study. All upper GI symptoms occurring at least once a week in the last 3 months were recorded. Diagnostic criteria of functional esophageal, gastroduodenal disorders and IBS were based on Rome III criteria. Risk factors were assessed using a multivariate logistic regression model. RESULTS: Of the 8906 consecutive patients, 751 patients met Rome III criteria for IBS and 735 IBS patients participated in the interview. Postprandial fullness (30.6%), belching (27.1%), and regurgitation (21.8%) were the three most prevalent upper GI symptoms in IBS. Functional dyspepsia (FD, 36.7%), belching disorders (27.1%), and functional heartburn (16.3%) were the three most frequent upper FGID in IBS patients. Female sex, divorced or widowed versus married status, defecation straining, reduced bowel movement, mixed IBS, abdominal distention, mild abdominal pain, moderate discomfort were positively associated with IBS-FD overlap. Female sex, drinking, moderate discomfort, and mild to moderate distension were independent risk factors for IBS-belching disorder overlap. CONCLUSIONS: The study provides detailed overlap spectra of upper FGID with IBS. Mixed IBS is an important risk factor for IBS-FD overlap, which deserved more concern. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/26875585/The_overlap_of_upper_functional_gastrointestinal_disorders_with_irritable_bowel_syndrome_in_Chinese_outpatients:_A_multicenter_study_ L2 - https://doi.org/10.1111/jgh.13317 DB - PRIME DP - Unbound Medicine ER -