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Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness.
J Dermatol. 2016 Aug; 43(8):919-27.JD

Abstract

Eosinophilic pustular folliculitis (EPF) is a non-infectious inflammatory dermatosis of unknown etiology that principally affects the hair follicles. There are three variants of EPF: (i) classic EPF; (ii) immunosuppression-associated EPF, which is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (IS/non-HIV); and (iii) infancy-associated EPF. Oral indomethacin is efficacious, especially for classic EPF. No comprehensive information on the efficacies of other medical management regimens is currently available. In this study, we surveyed regimens for EPF that were described in articles published between 1965 and 2013. In total, there were 1171 regimens; 874, 137, 45 and 115 of which were applied to classic, IS/HIV, IS/non-HIV and infancy-associated EPF, respectively. Classic EPF was preferentially treated with oral indomethacin with efficacy of 84% whereas topical steroids were preferred for IS/HIV, IS/non-HIV and infancy-associated EPF with efficacy of 47%, 73% and 82%, respectively. Other regimens such as oral Sairei-to (a Chinese-Japanese herbal medicine), diaminodiphenyl sulfone, cyclosporin and topical tacrolimus were effective for indomethacin-resistant cases. Although the preclusion of direct comparison among cases was one limitation, this study provides a dataset that is applicable to the construction of therapeutic algorithms for EPF.

Authors+Show Affiliations

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Department of Dermatology, Ijinkai Takeda General Hospital, Kyoto, Japan.Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Shiga Medical Center for Adults, Shiga, Japan.Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26875627

Citation

Nomura, Takashi, et al. "Eosinophilic Pustular Folliculitis: a Published Work-based Comprehensive Analysis of Therapeutic Responsiveness." The Journal of Dermatology, vol. 43, no. 8, 2016, pp. 919-27.
Nomura T, Katoh M, Yamamoto Y, et al. Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness. J Dermatol. 2016;43(8):919-27.
Nomura, T., Katoh, M., Yamamoto, Y., Miyachi, Y., & Kabashima, K. (2016). Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness. The Journal of Dermatology, 43(8), 919-27. https://doi.org/10.1111/1346-8138.13287
Nomura T, et al. Eosinophilic Pustular Folliculitis: a Published Work-based Comprehensive Analysis of Therapeutic Responsiveness. J Dermatol. 2016;43(8):919-27. PubMed PMID: 26875627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness. AU - Nomura,Takashi, AU - Katoh,Mayumi, AU - Yamamoto,Yosuke, AU - Miyachi,Yoshiki, AU - Kabashima,Kenji, Y1 - 2016/02/15/ PY - 2015/09/26/received PY - 2015/12/02/accepted PY - 2016/2/16/entrez PY - 2016/2/16/pubmed PY - 2017/5/23/medline KW - classic eosinophilic pustular folliculitis KW - eosinophilic pustular folliculitis KW - immunosuppression-associated eosinophilic pustular folliculitis KW - infancy-associated eosinophilic pustular folliculitis KW - therapy SP - 919 EP - 27 JF - The Journal of dermatology JO - J. Dermatol. VL - 43 IS - 8 N2 - Eosinophilic pustular folliculitis (EPF) is a non-infectious inflammatory dermatosis of unknown etiology that principally affects the hair follicles. There are three variants of EPF: (i) classic EPF; (ii) immunosuppression-associated EPF, which is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (IS/non-HIV); and (iii) infancy-associated EPF. Oral indomethacin is efficacious, especially for classic EPF. No comprehensive information on the efficacies of other medical management regimens is currently available. In this study, we surveyed regimens for EPF that were described in articles published between 1965 and 2013. In total, there were 1171 regimens; 874, 137, 45 and 115 of which were applied to classic, IS/HIV, IS/non-HIV and infancy-associated EPF, respectively. Classic EPF was preferentially treated with oral indomethacin with efficacy of 84% whereas topical steroids were preferred for IS/HIV, IS/non-HIV and infancy-associated EPF with efficacy of 47%, 73% and 82%, respectively. Other regimens such as oral Sairei-to (a Chinese-Japanese herbal medicine), diaminodiphenyl sulfone, cyclosporin and topical tacrolimus were effective for indomethacin-resistant cases. Although the preclusion of direct comparison among cases was one limitation, this study provides a dataset that is applicable to the construction of therapeutic algorithms for EPF. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/26875627/Eosinophilic_pustular_folliculitis:_A_published_work_based_comprehensive_analysis_of_therapeutic_responsiveness_ L2 - https://doi.org/10.1111/1346-8138.13287 DB - PRIME DP - Unbound Medicine ER -