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Differential influence of social versus isolate housing on vicarious fear learning in adolescent mice.
Behav Neurosci. 2016 Apr; 130(2):206-11.BN

Abstract

Laboratory rodents can adopt the pain or fear of nearby conspecifics. This phenotype conceptually lies within the domain of empathy, a bio-psycho-social process through which individuals come to share each other's emotion. Using a model of cue-conditioned fear, we show here that the expression of vicarious fear varies with respect to whether mice are raised socially or in solitude during adolescence. The impact of the adolescent housing environment was selective: (a) vicarious fear was more influenced than directly acquired fear, (b) "long-term" (24-h postconditioning) vicarious fear memories were stronger than "short-term" (15-min postconditioning) memories in socially reared mice whereas the opposite was true for isolate mice, and (c) females were more fearful than males. Housing differences during adolescence did not alter the general mobility of mice or their vocal response to receiving the unconditioned stimulus. Previous work with this mouse model underscored a genetic influence on vicarious fear learning, and the present study complements these findings by elucidating an interaction between the adolescent social environment and vicarious experience. Collectively, these findings are relevant to developing models of empathy amenable to mechanistic exploitation in the laboratory. (PsycINFO Database Record

Authors+Show Affiliations

Department of Behavioral Neuroscience, Oregon Health and Science University.Department of Behavioral Neuroscience, Oregon Health and Science University.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26881314

Citation

Panksepp, Jules B., and Garet P. Lahvis. "Differential Influence of Social Versus Isolate Housing On Vicarious Fear Learning in Adolescent Mice." Behavioral Neuroscience, vol. 130, no. 2, 2016, pp. 206-11.
Panksepp JB, Lahvis GP. Differential influence of social versus isolate housing on vicarious fear learning in adolescent mice. Behav Neurosci. 2016;130(2):206-11.
Panksepp, J. B., & Lahvis, G. P. (2016). Differential influence of social versus isolate housing on vicarious fear learning in adolescent mice. Behavioral Neuroscience, 130(2), 206-11. https://doi.org/10.1037/bne0000133
Panksepp JB, Lahvis GP. Differential Influence of Social Versus Isolate Housing On Vicarious Fear Learning in Adolescent Mice. Behav Neurosci. 2016;130(2):206-11. PubMed PMID: 26881314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential influence of social versus isolate housing on vicarious fear learning in adolescent mice. AU - Panksepp,Jules B, AU - Lahvis,Garet P, Y1 - 2016/02/15/ PY - 2016/2/17/entrez PY - 2016/2/18/pubmed PY - 2016/12/15/medline SP - 206 EP - 11 JF - Behavioral neuroscience JO - Behav Neurosci VL - 130 IS - 2 N2 - Laboratory rodents can adopt the pain or fear of nearby conspecifics. This phenotype conceptually lies within the domain of empathy, a bio-psycho-social process through which individuals come to share each other's emotion. Using a model of cue-conditioned fear, we show here that the expression of vicarious fear varies with respect to whether mice are raised socially or in solitude during adolescence. The impact of the adolescent housing environment was selective: (a) vicarious fear was more influenced than directly acquired fear, (b) "long-term" (24-h postconditioning) vicarious fear memories were stronger than "short-term" (15-min postconditioning) memories in socially reared mice whereas the opposite was true for isolate mice, and (c) females were more fearful than males. Housing differences during adolescence did not alter the general mobility of mice or their vocal response to receiving the unconditioned stimulus. Previous work with this mouse model underscored a genetic influence on vicarious fear learning, and the present study complements these findings by elucidating an interaction between the adolescent social environment and vicarious experience. Collectively, these findings are relevant to developing models of empathy amenable to mechanistic exploitation in the laboratory. (PsycINFO Database Record SN - 1939-0084 UR - https://www.unboundmedicine.com/medline/citation/26881314/Differential_influence_of_social_versus_isolate_housing_on_vicarious_fear_learning_in_adolescent_mice_ L2 - http://content.apa.org/journals/bne/130/2/206 DB - PRIME DP - Unbound Medicine ER -