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Increased oxidative stress in children with attention deficit hyperactivity disorder.
Redox Rep 2016; 21(6):248-53RR

Abstract

OBJECTIVES

The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD).

METHODS

Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls).

RESULTS

Age and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group.

DISCUSSION

We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.

Authors+Show Affiliations

a Department of Clinical Biochemistry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.b Department of Child and Adolescent Psychiatry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.a Department of Clinical Biochemistry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.c Department of Psychiatry , Balikligol State Hospital , Sanliurfa , Turkey.b Department of Child and Adolescent Psychiatry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.a Department of Clinical Biochemistry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.a Department of Clinical Biochemistry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26886057

Citation

Sezen, Hatice, et al. "Increased Oxidative Stress in Children With Attention Deficit Hyperactivity Disorder." Redox Report : Communications in Free Radical Research, vol. 21, no. 6, 2016, pp. 248-53.
Sezen H, Kandemir H, Savik E, et al. Increased oxidative stress in children with attention deficit hyperactivity disorder. Redox Rep. 2016;21(6):248-53.
Sezen, H., Kandemir, H., Savik, E., Basmacı Kandemir, S., Kilicaslan, F., Bilinc, H., & Aksoy, N. (2016). Increased oxidative stress in children with attention deficit hyperactivity disorder. Redox Report : Communications in Free Radical Research, 21(6), pp. 248-53. doi:10.1080/13510002.2015.1116729.
Sezen H, et al. Increased Oxidative Stress in Children With Attention Deficit Hyperactivity Disorder. Redox Rep. 2016;21(6):248-53. PubMed PMID: 26886057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased oxidative stress in children with attention deficit hyperactivity disorder. AU - Sezen,Hatice, AU - Kandemir,Hasan, AU - Savik,Emin, AU - Basmacı Kandemir,Sultan, AU - Kilicaslan,Fethiye, AU - Bilinc,Hasan, AU - Aksoy,Nurten, Y1 - 2016/02/18/ PY - 2016/2/18/entrez PY - 2016/2/18/pubmed PY - 2017/5/16/medline KW - Arylesterase KW - Attention deficit hyperactivity disorder KW - Oxidative stress KW - Paraxonase-1 SP - 248 EP - 53 JF - Redox report : communications in free radical research JO - Redox Rep. VL - 21 IS - 6 N2 - OBJECTIVES: The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD). METHODS: Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls). RESULTS: Age and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group. DISCUSSION: We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD. SN - 1743-2928 UR - https://www.unboundmedicine.com/medline/citation/26886057/Increased_oxidative_stress_in_children_with_attention_deficit_hyperactivity_disorder_ L2 - http://www.tandfonline.com/doi/full/10.1080/13510002.2015.1116729 DB - PRIME DP - Unbound Medicine ER -