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Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization.
J Pharm Sci. 2016 Mar; 105(3):1156-63.JP

Abstract

This study aimed to investigate the surface energy factors behind improved aerosolization performance of spray-dried colistin powder formulations compared with those produced by jet milling. Inhalable colistin powder formulations were produced by jet milling or spray drying (with or without l-leucine). Scanning electron micrographs showed the jet-milled particles had irregularly angular shapes, whereas the spray-dried particles were more spherical. Significantly higher fine particle fractions were measured for the spray-dried (43.8%-49.6%) versus the jet-milled formulation (28.4%) from a Rotahaler at 60 L/min; albeit the size distribution of the jet-milled powder was smaller. Surprisingly, addition of l-leucine in the spray drying feed solution gave no significant improvement in fine particle fraction. As measured by inverse gas chromatography, spray-dried formulations had significantly (p < 0.001) lower dispersive, specific, and total surface energy values and more uniform surface energy distributions than the jet-milled powder. Interestingly, no significant difference was measured in the specific and total surface energy values between the spray-dried formulation with or without l-leucine. Based on our previous findings in the self-assembling behavior of colistin in aqueous solution and the surface energy data obtained here, we propose the self-assembly of colistin molecules during spray drying contributed significantly to the reduction of surface free energy and the superior aerosolization performance.

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Authors+Show Affiliations

Jong T
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Li J
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Morton DA
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. Electronic address: david.morton@monash.edu.
Zhou QT
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907-2091. Electronic address: tonyzhou@purdue.edu.
Larson I
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. Electronic address: ian.larson@monash.edu.

MeSH

Administration, InhalationAerosolsChemistry, PharmaceuticalColistinDry Powder InhalersLeucineMicroscopy, Electron, ScanningParticle SizePowdersSolutions

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26886330

Citation

Jong, Teresa, et al. "Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization." Journal of Pharmaceutical Sciences, vol. 105, no. 3, 2016, pp. 1156-63.
Jong T, Li J, Morton DA, et al. Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization. J Pharm Sci. 2016;105(3):1156-63.
Jong, T., Li, J., Morton, D. A., Zhou, Q. T., & Larson, I. (2016). Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization. Journal of Pharmaceutical Sciences, 105(3), 1156-63. https://doi.org/10.1016/S0022-3549(15)00189-6
Jong T, et al. Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization. J Pharm Sci. 2016;105(3):1156-63. PubMed PMID: 26886330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization. AU - Jong,Teresa, AU - Li,Jian, AU - Morton,David A V, AU - Zhou,Qi Tony, AU - Larson,Ian, Y1 - 2016/01/30/ PY - 2015/09/03/received PY - 2015/12/01/revised PY - 2015/12/04/accepted PY - 2017/03/01/pmc-release PY - 2016/2/18/entrez PY - 2016/2/18/pubmed PY - 2016/12/15/medline KW - antibiotics KW - colistin KW - dry powder inhaler KW - inverse gas chromatography KW - jet milling KW - respiratory infection KW - self-assembly KW - spray drying KW - surface energy SP - 1156 EP - 63 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 105 IS - 3 N2 - This study aimed to investigate the surface energy factors behind improved aerosolization performance of spray-dried colistin powder formulations compared with those produced by jet milling. Inhalable colistin powder formulations were produced by jet milling or spray drying (with or without l-leucine). Scanning electron micrographs showed the jet-milled particles had irregularly angular shapes, whereas the spray-dried particles were more spherical. Significantly higher fine particle fractions were measured for the spray-dried (43.8%-49.6%) versus the jet-milled formulation (28.4%) from a Rotahaler at 60 L/min; albeit the size distribution of the jet-milled powder was smaller. Surprisingly, addition of l-leucine in the spray drying feed solution gave no significant improvement in fine particle fraction. As measured by inverse gas chromatography, spray-dried formulations had significantly (p < 0.001) lower dispersive, specific, and total surface energy values and more uniform surface energy distributions than the jet-milled powder. Interestingly, no significant difference was measured in the specific and total surface energy values between the spray-dried formulation with or without l-leucine. Based on our previous findings in the self-assembling behavior of colistin in aqueous solution and the surface energy data obtained here, we propose the self-assembly of colistin molecules during spray drying contributed significantly to the reduction of surface free energy and the superior aerosolization performance. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/26886330/Investigation_of_the_Changes_in_Aerosolization_Behavior_Between_the_Jet_Milled_and_Spray_Dried_Colistin_Powders_Through_Surface_Energy_Characterization_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓11 ↑38]

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