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Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort.
Am J Clin Nutr. 2016 Apr; 103(4):999-1007.AJ

Abstract

BACKGROUND

High intake of whole grains has been associated with lower risk of coronary heart disease; however, the research that has been used to evaluate different effects of different whole-grain cereals (e.g., wheat, rye, and oats) has been sparse.

OBJECTIVE

We investigated the association between whole-grain intake in terms of total intake and intakes of different cereals and myocardial infarction.

DESIGN

This prospective study included 54,871 Danish adults aged 50-64 y, of whom 2329 individuals developed myocardial infarction (13.6 y of follow-up). Detailed information on daily intake of whole-grain products was available from a self-administered food-frequency questionnaire, and intakes of total whole grain and whole-grain species (wheat, rye, and oats) were estimated. The association between intake of whole grains and risk of myocardial infarction was examined with the use of a Cox proportional hazards model adjusted for potential confounders.

RESULTS

For both men and women with total whole-grain intake in the highest quartile, lower risks of myocardial infarction were shown [HRs: 0.75 (95% CI: 0.65, 0.86) and 0.73 (95% CI: 0.58, 0.91), respectively] than for individuals with intake in the lowest quartile. When the specific cereal species were considered, rye and oats, but not wheat, were associated with lower myocardial infarction risk in men. No significant associations were seen in women. For total whole-grain products, significantly lower myocardial infarction risks were seen with higher intakes in both men and women. Rye bread (in men and women) and oatmeal (in men) were associated with significantly lower risk of myocardial infarction, whereas no significant association was shown for whole-grain bread, crispbread, and wheat.

CONCLUSION

In this study, we provide support for the hypothesis that whole-grain intake is related to lower risk of myocardial infarction and suggest that the cereals rye and oats might especially hold a beneficial effect.

Authors+Show Affiliations

Danish Cancer Society Research Center, Copenhagen, Denmark;Danish Cancer Society Research Center, Copenhagen, Denmark; ceciliek@cancer.dk.Department of Public Health, Section of Social Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;Danish Cancer Society Research Center, Copenhagen, Denmark;Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark; and Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.Danish Cancer Society Research Center, Copenhagen, Denmark;Danish Cancer Society Research Center, Copenhagen, Denmark;Danish Cancer Society Research Center, Copenhagen, Denmark;

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26888710

Citation

Helnæs, Anne, et al. "Intake of Whole Grains Is Associated With Lower Risk of Myocardial Infarction: the Danish Diet, Cancer and Health Cohort." The American Journal of Clinical Nutrition, vol. 103, no. 4, 2016, pp. 999-1007.
Helnæs A, Kyrø C, Andersen I, et al. Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort. Am J Clin Nutr. 2016;103(4):999-1007.
Helnæs, A., Kyrø, C., Andersen, I., Lacoppidan, S., Overvad, K., Christensen, J., Tjønneland, A., & Olsen, A. (2016). Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort. The American Journal of Clinical Nutrition, 103(4), 999-1007. https://doi.org/10.3945/ajcn.115.124271
Helnæs A, et al. Intake of Whole Grains Is Associated With Lower Risk of Myocardial Infarction: the Danish Diet, Cancer and Health Cohort. Am J Clin Nutr. 2016;103(4):999-1007. PubMed PMID: 26888710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort. AU - Helnæs,Anne, AU - Kyrø,Cecilie, AU - Andersen,Ingelise, AU - Lacoppidan,Sandra, AU - Overvad,Kim, AU - Christensen,Jane, AU - Tjønneland,Anne, AU - Olsen,Anja, Y1 - 2016/02/17/ PY - 2015/09/22/received PY - 2016/01/13/accepted PY - 2016/2/19/entrez PY - 2016/2/19/pubmed PY - 2016/8/16/medline KW - cardiovascular disease KW - cereal KW - cohort KW - coronary heart disease KW - ischemic heart disease KW - myocardial infarction KW - oats KW - rye KW - wheat KW - whole grains SP - 999 EP - 1007 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 103 IS - 4 N2 - BACKGROUND: High intake of whole grains has been associated with lower risk of coronary heart disease; however, the research that has been used to evaluate different effects of different whole-grain cereals (e.g., wheat, rye, and oats) has been sparse. OBJECTIVE: We investigated the association between whole-grain intake in terms of total intake and intakes of different cereals and myocardial infarction. DESIGN: This prospective study included 54,871 Danish adults aged 50-64 y, of whom 2329 individuals developed myocardial infarction (13.6 y of follow-up). Detailed information on daily intake of whole-grain products was available from a self-administered food-frequency questionnaire, and intakes of total whole grain and whole-grain species (wheat, rye, and oats) were estimated. The association between intake of whole grains and risk of myocardial infarction was examined with the use of a Cox proportional hazards model adjusted for potential confounders. RESULTS: For both men and women with total whole-grain intake in the highest quartile, lower risks of myocardial infarction were shown [HRs: 0.75 (95% CI: 0.65, 0.86) and 0.73 (95% CI: 0.58, 0.91), respectively] than for individuals with intake in the lowest quartile. When the specific cereal species were considered, rye and oats, but not wheat, were associated with lower myocardial infarction risk in men. No significant associations were seen in women. For total whole-grain products, significantly lower myocardial infarction risks were seen with higher intakes in both men and women. Rye bread (in men and women) and oatmeal (in men) were associated with significantly lower risk of myocardial infarction, whereas no significant association was shown for whole-grain bread, crispbread, and wheat. CONCLUSION: In this study, we provide support for the hypothesis that whole-grain intake is related to lower risk of myocardial infarction and suggest that the cereals rye and oats might especially hold a beneficial effect. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26888710/Intake_of_whole_grains_is_associated_with_lower_risk_of_myocardial_infarction:_the_Danish_Diet_Cancer_and_Health_Cohort_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.124271 DB - PRIME DP - Unbound Medicine ER -