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Retinal Nerve Fiber Layer Thinning in Alzheimer's Disease: A Case-Control Study in Comparison to Normal Aging, Parkinson's Disease, and Non-Alzheimer's Dementia.
Am J Alzheimers Dis Other Demen. 2016 08; 31(5):430-6.AJ

Abstract

Retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, and macular volume (MV) utilizing spectral domain optical coherence tomography (SD-OCT) were compared among patients with Alzheimer's disease (AD) dementia, non-Alzheimer's disease (non-AD) dementia, amnestic mild cognitive impairment (aMCI), Parkinson's disease (PD), and age- and sex-matched controls in a cross-sectional cohort study. A total of 116 participants were diagnosed and evaluated (21 AD, 20 aMCI, 20 non-AD, 20 PD, and 34 controls) after comprehensive neurological, neuropsychology, and magnetic resonance imaging (MRI) volumetric evaluations. Retinal nerve fiber layer thickness, GCL thickness, and MV were measured. Analysis of variance models were used to compare groups on MRI volumetric measures, cognitive test results, and SD-OCT measures. Associations between SD-OCT measures and other measures were performed using mixed-effect models. Spectral domain optical coherence tomography analysis of retinal markers, including RNFL thickness, GCL thickness, and MV, did not differ between amnestic MCI, AD dementia, PD, non-AD, dementia, and age- and sex-matched controls in a well-characterized patient cohort.

Authors+Show Affiliations

Department of Neurology, Cleveland Clinic, Cleveland, OH, USA Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA pillaij@ccf.org.Department of Neurology, Cleveland Clinic, Cleveland, OH, USA Mellen Center for Multiple Sclerosis, Cleveland, OH, USA.Department of Neurology, Cleveland Clinic, Cleveland, OH, USA Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.Department of Neurology, Cleveland Clinic, Cleveland, OH, USA Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA Mellen Center for Multiple Sclerosis, Cleveland, OH, USA.Department of Neurology, Cleveland Clinic, Cleveland, OH, USA Center for Neurological Restoration, Cleveland, OH, USA.Quantitative Health Sciences, Cleveland, OH, USA.Imaging Institute, Cleveland, OH, USA.Ophthalmic Imaging Center, Cole Eye Institute, Cleveland, OH, USA.Department of Neurology, Cleveland Clinic, Cleveland, OH, USA Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26888864

Citation

Pillai, Jagan A., et al. "Retinal Nerve Fiber Layer Thinning in Alzheimer's Disease: a Case-Control Study in Comparison to Normal Aging, Parkinson's Disease, and Non-Alzheimer's Dementia." American Journal of Alzheimer's Disease and Other Dementias, vol. 31, no. 5, 2016, pp. 430-6.
Pillai JA, Bermel R, Bonner-Jackson A, et al. Retinal Nerve Fiber Layer Thinning in Alzheimer's Disease: A Case-Control Study in Comparison to Normal Aging, Parkinson's Disease, and Non-Alzheimer's Dementia. Am J Alzheimers Dis Other Demen. 2016;31(5):430-6.
Pillai, J. A., Bermel, R., Bonner-Jackson, A., Rae-Grant, A., Fernandez, H., Bena, J., Jones, S. E., Ehlers, J. P., & Leverenz, J. B. (2016). Retinal Nerve Fiber Layer Thinning in Alzheimer's Disease: A Case-Control Study in Comparison to Normal Aging, Parkinson's Disease, and Non-Alzheimer's Dementia. American Journal of Alzheimer's Disease and Other Dementias, 31(5), 430-6. https://doi.org/10.1177/1533317515628053
Pillai JA, et al. Retinal Nerve Fiber Layer Thinning in Alzheimer's Disease: a Case-Control Study in Comparison to Normal Aging, Parkinson's Disease, and Non-Alzheimer's Dementia. Am J Alzheimers Dis Other Demen. 2016;31(5):430-6. PubMed PMID: 26888864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal Nerve Fiber Layer Thinning in Alzheimer's Disease: A Case-Control Study in Comparison to Normal Aging, Parkinson's Disease, and Non-Alzheimer's Dementia. AU - Pillai,Jagan A, AU - Bermel,Robert, AU - Bonner-Jackson,Aaron, AU - Rae-Grant,Alexander, AU - Fernandez,Hubert, AU - Bena,James, AU - Jones,Stephen E, AU - Ehlers,Justis P, AU - Leverenz,James B, Y1 - 2016/02/16/ PY - 2016/2/19/entrez PY - 2016/2/19/pubmed PY - 2017/10/24/medline KW - Alzheimer’s disease KW - Parkinson’s disease KW - dementia KW - mild cognitive impairment KW - non-Alzheimer’s dementia KW - optical coherence tomography KW - retinal nerve fiber thickness SP - 430 EP - 6 JF - American journal of Alzheimer's disease and other dementias JO - Am J Alzheimers Dis Other Demen VL - 31 IS - 5 N2 - Retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, and macular volume (MV) utilizing spectral domain optical coherence tomography (SD-OCT) were compared among patients with Alzheimer's disease (AD) dementia, non-Alzheimer's disease (non-AD) dementia, amnestic mild cognitive impairment (aMCI), Parkinson's disease (PD), and age- and sex-matched controls in a cross-sectional cohort study. A total of 116 participants were diagnosed and evaluated (21 AD, 20 aMCI, 20 non-AD, 20 PD, and 34 controls) after comprehensive neurological, neuropsychology, and magnetic resonance imaging (MRI) volumetric evaluations. Retinal nerve fiber layer thickness, GCL thickness, and MV were measured. Analysis of variance models were used to compare groups on MRI volumetric measures, cognitive test results, and SD-OCT measures. Associations between SD-OCT measures and other measures were performed using mixed-effect models. Spectral domain optical coherence tomography analysis of retinal markers, including RNFL thickness, GCL thickness, and MV, did not differ between amnestic MCI, AD dementia, PD, non-AD, dementia, and age- and sex-matched controls in a well-characterized patient cohort. SN - 1938-2731 UR - https://www.unboundmedicine.com/medline/citation/26888864/Retinal_Nerve_Fiber_Layer_Thinning_in_Alzheimer's_Disease:_A_Case_Control_Study_in_Comparison_to_Normal_Aging_Parkinson's_Disease_and_Non_Alzheimer's_Dementia_ L2 - https://journals.sagepub.com/doi/10.1177/1533317515628053?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -