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Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels.
J Virol. 2016 May; 90(9):4838-4842.JV

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

Authors+Show Affiliations

Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.IRTA, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.UAB, Centre de Recerca en Sanitat Animal (CReSA), Unitat Mixta IRTA-UAB, Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain. Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.Department of Pathology, University of Veterinary Medicine, Hannover, Germany.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands. Artemis One Health, Utrecht, The Netherlands. Center for Infection Medicine and Zoonoses Research (RIZ), University of Veterinary Medicine, Hannover, Germany.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands b.haagmans@erasmusmc.nl.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26889022

Citation

Widagdo, W, et al. "Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels." Journal of Virology, vol. 90, no. 9, 2016, pp. 4838-4842.
Widagdo W, Raj VS, Schipper D, et al. Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels. J Virol. 2016;90(9):4838-4842.
Widagdo, W., Raj, V. S., Schipper, D., Kolijn, K., van Leenders, G. J. L. H., Bosch, B. J., Bensaid, A., Segalés, J., Baumgärtner, W., Osterhaus, A. D. M. E., Koopmans, M. P., van den Brand, J. M. A., & Haagmans, B. L. (2016). Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels. Journal of Virology, 90(9), 4838-4842. https://doi.org/10.1128/JVI.02994-15
Widagdo W, et al. Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels. J Virol. 2016;90(9):4838-4842. PubMed PMID: 26889022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels. AU - Widagdo,W, AU - Raj,V Stalin, AU - Schipper,Debby, AU - Kolijn,Kimberley, AU - van Leenders,Geert J L H, AU - Bosch,Berend J, AU - Bensaid,Albert, AU - Segalés,Joaquim, AU - Baumgärtner,Wolfgang, AU - Osterhaus,Albert D M E, AU - Koopmans,Marion P, AU - van den Brand,Judith M A, AU - Haagmans,Bart L, Y1 - 2016/04/14/ PY - 2015/11/26/received PY - 2016/02/08/accepted PY - 2016/2/19/entrez PY - 2016/2/19/pubmed PY - 2016/8/26/medline SP - 4838 EP - 4842 JF - Journal of virology JO - J Virol VL - 90 IS - 9 N2 - Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission. SN - 1098-5514 UR - https://www.unboundmedicine.com/medline/citation/26889022/Differential_Expression_of_the_Middle_East_Respiratory_Syndrome_Coronavirus_Receptor_in_the_Upper_Respiratory_Tracts_of_Humans_and_Dromedary_Camels_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26889022/ DB - PRIME DP - Unbound Medicine ER -