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Paraneoplastic Choreoathetosis in a Patient with Small Cell Lung Carcinoma and Anti-CRMP5/CV2: A Case Report.
Case Rep Neurol. 2016 Jan-Apr; 8(1):16-9.CR

Abstract

INTRODUCTION

The occurrence of more or less monosymptomatic paraneoplastic choreoathetosis associated with anti-CRMP5/CV2 antibodies is rare. Typically, such autoantibodies are associated with a more classical syndrome - paraneoplastic encephalomyelitis. Frequently, small cell lung carcinoma (SCLC) is the related neoplastic finding.

CASE REPORT

We present a 71-year-old woman who developed visual symptoms with papilledema and chorea. Anti-CRMP5/CV2 antibodies were a feature of both the serum and cerebrospinal fluid. Although SCLC was suspected already at the time of the initial examinations, no signs of primary or metastatic tumors were revealed on chest X-ray, MRI or whole-body PET scan. EEG and bronchoscopy were also unremarkable. However, 6 months after the onset, a repeated PET scan and subsequent bronchoscopic biopsy revealed SCLC. In spite of chemotherapy, the SCLC progressed, and the patient died 14 months after the onset of the symptoms.

CONCLUSION

We report paraneoplastic choreoathetosis associated with anti-CRMP5/CV2 antibodies. Such published case histories are rare. Although expected, we did not find any reduced signal intensity at the basal ganglia on the T1-weighted or increased intensity on the T2-weighted MRI scans.

Authors+Show Affiliations

Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Copenhagen, Denmark.Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark.Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Copenhagen, Denmark.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

26889151

Citation

Aydin, Dogu, et al. "Paraneoplastic Choreoathetosis in a Patient With Small Cell Lung Carcinoma and Anti-CRMP5/CV2: a Case Report." Case Reports in Neurology, vol. 8, no. 1, 2016, pp. 16-9.
Aydin D, Somnier F, Lassen LH. Paraneoplastic Choreoathetosis in a Patient with Small Cell Lung Carcinoma and Anti-CRMP5/CV2: A Case Report. Case Rep Neurol. 2016;8(1):16-9.
Aydin, D., Somnier, F., & Lassen, L. H. (2016). Paraneoplastic Choreoathetosis in a Patient with Small Cell Lung Carcinoma and Anti-CRMP5/CV2: A Case Report. Case Reports in Neurology, 8(1), 16-9. https://doi.org/10.1159/000443522
Aydin D, Somnier F, Lassen LH. Paraneoplastic Choreoathetosis in a Patient With Small Cell Lung Carcinoma and Anti-CRMP5/CV2: a Case Report. Case Rep Neurol. 2016 Jan-Apr;8(1):16-9. PubMed PMID: 26889151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraneoplastic Choreoathetosis in a Patient with Small Cell Lung Carcinoma and Anti-CRMP5/CV2: A Case Report. AU - Aydin,Dogu, AU - Somnier,Finn, AU - Lassen,Lisbeth H, Y1 - 2016/01/08/ PY - 2016/2/19/entrez PY - 2016/2/19/pubmed PY - 2016/2/19/medline KW - Anti-CRMP5/CV2 antibodies KW - Cancer KW - Movement disorder KW - Nervous system KW - Paraneoplastic choreoathetosis KW - Small cell lung carcinoma SP - 16 EP - 9 JF - Case reports in neurology JO - Case Rep Neurol VL - 8 IS - 1 N2 - INTRODUCTION: The occurrence of more or less monosymptomatic paraneoplastic choreoathetosis associated with anti-CRMP5/CV2 antibodies is rare. Typically, such autoantibodies are associated with a more classical syndrome - paraneoplastic encephalomyelitis. Frequently, small cell lung carcinoma (SCLC) is the related neoplastic finding. CASE REPORT: We present a 71-year-old woman who developed visual symptoms with papilledema and chorea. Anti-CRMP5/CV2 antibodies were a feature of both the serum and cerebrospinal fluid. Although SCLC was suspected already at the time of the initial examinations, no signs of primary or metastatic tumors were revealed on chest X-ray, MRI or whole-body PET scan. EEG and bronchoscopy were also unremarkable. However, 6 months after the onset, a repeated PET scan and subsequent bronchoscopic biopsy revealed SCLC. In spite of chemotherapy, the SCLC progressed, and the patient died 14 months after the onset of the symptoms. CONCLUSION: We report paraneoplastic choreoathetosis associated with anti-CRMP5/CV2 antibodies. Such published case histories are rare. Although expected, we did not find any reduced signal intensity at the basal ganglia on the T1-weighted or increased intensity on the T2-weighted MRI scans. SN - 1662-680X UR - https://www.unboundmedicine.com/medline/citation/26889151/Paraneoplastic_Choreoathetosis_in_a_Patient_with_Small_Cell_Lung_Carcinoma_and_Anti_CRMP5/CV2:_A_Case_Report_ L2 - https://www.karger.com?DOI=10.1159/000443522 DB - PRIME DP - Unbound Medicine ER -
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