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Correlation of clinical and biochemical hyperandrogenism in Thai women with polycystic ovary syndrome.
J Obstet Gynaecol Res. 2016 Jun; 42(6):678-83.JO

Abstract

AIM

The aim of this study was to determine the correlation of clinical hyperandrogenism and biochemical hyperandrogenism (hyperandrogenemia) in Thai women with polycystic ovary syndrome (PCOS).

METHODS

This cross-sectional study was conducted at Siriraj Hospital, Thailand. Subjects were 145 women with PCOS who were diagnosed in accordance with the revised Rotterdam 2003 criteria and registered during January to July 2008. Clinical hyperandrogenism was assessed using the modified Ferriman-Gallwey score for hirsutism, the American Academy of Dermatology criteria for severity of acne, and the Ludwig scale for androgenic alopecia and virilization. Biochemical hyperandrogenism was determined from serum concentration of total testosterone (TT), dehydroepiandrosterone sulfate and free testosterone (FT).

RESULTS

The participants had a mean age of 25.5 ± 6.5 years and a body mass index of 26.2 ± 6.9 kg/m(2) . The most common presenting symptom was oligomenorrhea or amenorrhea. The most common expression of clinical hyperandrogenism was acne (56.6%). Most of the participants (84.8%) had high serum-FT. There was a statistically significant correlation between clinical and biochemical hyperandrogenism in the following pairs: hirsutism and FT (r = 0.3, P < 0.001); hirsutism and TT (r = 0.26, P < 0.001); and acne and TT (r = 0.26, P = 0.002). The others had little or no correlations.

CONCLUSION

Clinical hyperandrogenism is not a good predictor for biochemical hyperandrogenism in Thai women with PCOS. A modified Ferriman-Gallwey score cut-off point of 8 has low sensitivity but high specificity for hyperandrogenemia; therefore, it is useful for the diagnosis but not useful for the exclusion of hyperandrogenemia in Thai women with PCOS.

Authors+Show Affiliations

Gynecologic Endocrinology Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Gynecologic Endocrinology Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Gynecologic Endocrinology Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Gynecologic Endocrinology Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Gynecologic Endocrinology Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.Gynecologic Endocrinology Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26890011

Citation

Leerasiri, Pichai, et al. "Correlation of Clinical and Biochemical Hyperandrogenism in Thai Women With Polycystic Ovary Syndrome." The Journal of Obstetrics and Gynaecology Research, vol. 42, no. 6, 2016, pp. 678-83.
Leerasiri P, Wongwananuruk T, Indhavivadhana S, et al. Correlation of clinical and biochemical hyperandrogenism in Thai women with polycystic ovary syndrome. J Obstet Gynaecol Res. 2016;42(6):678-83.
Leerasiri, P., Wongwananuruk, T., Indhavivadhana, S., Techatraisak, K., Rattanachaiyanont, M., & Angsuwathana, S. (2016). Correlation of clinical and biochemical hyperandrogenism in Thai women with polycystic ovary syndrome. The Journal of Obstetrics and Gynaecology Research, 42(6), 678-83. https://doi.org/10.1111/jog.12945
Leerasiri P, et al. Correlation of Clinical and Biochemical Hyperandrogenism in Thai Women With Polycystic Ovary Syndrome. J Obstet Gynaecol Res. 2016;42(6):678-83. PubMed PMID: 26890011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of clinical and biochemical hyperandrogenism in Thai women with polycystic ovary syndrome. AU - Leerasiri,Pichai, AU - Wongwananuruk,Thanyarat, AU - Indhavivadhana,Suchada, AU - Techatraisak,Kitirat, AU - Rattanachaiyanont,Manee, AU - Angsuwathana,Surasak, Y1 - 2016/02/18/ PY - 2015/06/25/received PY - 2015/11/05/revised PY - 2015/12/07/accepted PY - 2016/2/19/entrez PY - 2016/2/19/pubmed PY - 2017/4/14/medline KW - PCOS, Thai women KW - correlation KW - hyperandrogenemia KW - hyperandrogenism SP - 678 EP - 83 JF - The journal of obstetrics and gynaecology research JO - J Obstet Gynaecol Res VL - 42 IS - 6 N2 - AIM: The aim of this study was to determine the correlation of clinical hyperandrogenism and biochemical hyperandrogenism (hyperandrogenemia) in Thai women with polycystic ovary syndrome (PCOS). METHODS: This cross-sectional study was conducted at Siriraj Hospital, Thailand. Subjects were 145 women with PCOS who were diagnosed in accordance with the revised Rotterdam 2003 criteria and registered during January to July 2008. Clinical hyperandrogenism was assessed using the modified Ferriman-Gallwey score for hirsutism, the American Academy of Dermatology criteria for severity of acne, and the Ludwig scale for androgenic alopecia and virilization. Biochemical hyperandrogenism was determined from serum concentration of total testosterone (TT), dehydroepiandrosterone sulfate and free testosterone (FT). RESULTS: The participants had a mean age of 25.5 ± 6.5 years and a body mass index of 26.2 ± 6.9 kg/m(2) . The most common presenting symptom was oligomenorrhea or amenorrhea. The most common expression of clinical hyperandrogenism was acne (56.6%). Most of the participants (84.8%) had high serum-FT. There was a statistically significant correlation between clinical and biochemical hyperandrogenism in the following pairs: hirsutism and FT (r = 0.3, P < 0.001); hirsutism and TT (r = 0.26, P < 0.001); and acne and TT (r = 0.26, P = 0.002). The others had little or no correlations. CONCLUSION: Clinical hyperandrogenism is not a good predictor for biochemical hyperandrogenism in Thai women with PCOS. A modified Ferriman-Gallwey score cut-off point of 8 has low sensitivity but high specificity for hyperandrogenemia; therefore, it is useful for the diagnosis but not useful for the exclusion of hyperandrogenemia in Thai women with PCOS. SN - 1447-0756 UR - https://www.unboundmedicine.com/medline/citation/26890011/Correlation_of_clinical_and_biochemical_hyperandrogenism_in_Thai_women_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -