TY - JOUR T1 - Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders. AU - Donix,Markus, AU - Bauer,Michael, PY - 2015/09/12/received PY - 2015/10/28/revised PY - 2015/11/11/accepted PY - 2016/2/20/entrez PY - 2016/2/20/pubmed PY - 2017/10/3/medline SP - 873 EP - 8 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 13 IS - 8 N2 - BACKGROUND: Lithium shows neuroprotective and neurotrophic effects in vitro and in vivo. Due to its involvement in hippocampal neurogenesis and the interaction with beta-amyloid and neurofibrillary tangle metabolism it has been hypothesized that lithium could have the potential to influence the development of dementia. METHOD: Using the PubMed database and cross-reference search strategies our aim was to specifically identify population (cohort or case-control) studies investigating the association between lithium and dementia. RESULTS: Data from large cohort studies suggest an association between lithium treatment and dementia risk reduction or reduced dementia severity. Studies with smaller sample sizes yield more variable findings. CONCLUSIONS: Lithium may reduce the risk of dementia among middle-aged and older people. Beneficial lithium effects are possibly limited to specific types of neurodegenerative processes. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/26892288/Population_Studies_of_Association_Between_Lithium_and_Risk_of_Neurodegenerative_Disorders_ DB - PRIME DP - Unbound Medicine ER -