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Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders.
Curr Alzheimer Res. 2016; 13(8):873-8.CA

Abstract

BACKGROUND

Lithium shows neuroprotective and neurotrophic effects in vitro and in vivo. Due to its involvement in hippocampal neurogenesis and the interaction with beta-amyloid and neurofibrillary tangle metabolism it has been hypothesized that lithium could have the potential to influence the development of dementia.

METHOD

Using the PubMed database and cross-reference search strategies our aim was to specifically identify population (cohort or case-control) studies investigating the association between lithium and dementia.

RESULTS

Data from large cohort studies suggest an association between lithium treatment and dementia risk reduction or reduced dementia severity. Studies with smaller sample sizes yield more variable findings.

CONCLUSIONS

Lithium may reduce the risk of dementia among middle-aged and older people. Beneficial lithium effects are possibly limited to specific types of neurodegenerative processes.

Authors+Show Affiliations

Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany. markus.donix@uniklinikum-dresden.de.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26892288

Citation

Donix, Markus, and Michael Bauer. "Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders." Current Alzheimer Research, vol. 13, no. 8, 2016, pp. 873-8.
Donix M, Bauer M. Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders. Curr Alzheimer Res. 2016;13(8):873-8.
Donix, M., & Bauer, M. (2016). Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders. Current Alzheimer Research, 13(8), 873-8.
Donix M, Bauer M. Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders. Curr Alzheimer Res. 2016;13(8):873-8. PubMed PMID: 26892288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders. AU - Donix,Markus, AU - Bauer,Michael, PY - 2015/09/12/received PY - 2015/10/28/revised PY - 2015/11/11/accepted PY - 2016/2/20/entrez PY - 2016/2/20/pubmed PY - 2017/10/3/medline SP - 873 EP - 8 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 13 IS - 8 N2 - BACKGROUND: Lithium shows neuroprotective and neurotrophic effects in vitro and in vivo. Due to its involvement in hippocampal neurogenesis and the interaction with beta-amyloid and neurofibrillary tangle metabolism it has been hypothesized that lithium could have the potential to influence the development of dementia. METHOD: Using the PubMed database and cross-reference search strategies our aim was to specifically identify population (cohort or case-control) studies investigating the association between lithium and dementia. RESULTS: Data from large cohort studies suggest an association between lithium treatment and dementia risk reduction or reduced dementia severity. Studies with smaller sample sizes yield more variable findings. CONCLUSIONS: Lithium may reduce the risk of dementia among middle-aged and older people. Beneficial lithium effects are possibly limited to specific types of neurodegenerative processes. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/26892288/Population_Studies_of_Association_Between_Lithium_and_Risk_of_Neurodegenerative_Disorders_ DB - PRIME DP - Unbound Medicine ER -
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