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Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans.
Lipids Health Dis. 2016 Feb 18; 15:32.LH

Abstract

BACKGROUND

A plant-based strategy to improve long-chain (LC) omega (n)-3 PUFA supply in humans involves dietary supplementation with oils containing α-linolenic acid (ALA) alone or in combination with stearidonic acid (SDA). The study aimed to compare the effects of echium oil (EO) and linseed oil (LO) on LC n-3 PUFA accumulation in blood and on clinical markers.

METHODS

In two double-blind, parallel-arm, randomized controlled studies, all volunteers started with 17 g/d run-in oil (2 weeks). Thereafter, subjects received diets enriched in study 1 with EO (5 g ALA + 2 g SDA; n = 59) or in study 2 with LO (5 g ALA; n = 9) daily for 8 weeks. The smaller control groups received fish oil (FO; n = 19) or olive oil (OO; n = 18). Participants were instructed to restrict their dietary n-3 PUFA intake throughout the studies (e.g., no fish). To investigate the influence of age and BMI on the conversion of ALA and SDA as well as clinical markers, the subjects recruited for EO and LO treatment were divided into three subgroups (two age groups 20-35 y; 49-69 y with BMI 18-25 kg/m(2) and one group with older, overweight subjects (age 49-69 y; BMI >25 kg/m(2)).

RESULTS

In plasma, red blood cells (RBC), and peripheral blood mononuclear cells (PBMC), EPA and docosapentaenoic acid (DPA) were ~25 % higher following EO compared to LO. Comparing all treatments, the effectiveness of increasing EPA and DPA in plasma, RBC, and PBMC was on average 100:25:10:0 and 100:50:25:0 for FO:EO:LO:OO, respectively. EO led to a lower arachidonic acid/EPA-ratio compared to LO in plasma, RBC, and PBMC. Following EO, final DHA was not greater compared to LO. Higher BMI correlated negatively with increases in plasma EPA and DPA after EO supplementation, but not after LO supplementation. Decreasing effect on plasma LDL-C and serum insulin was greater with EO than with LO.

CONCLUSIONS

Daily intake of SDA-containing EO is a better supplement than LO for increasing EPA and DPA in blood. However, neither EO nor LO maintained blood DHA status in the absence of fish/seafood consumption.

TRIAL REGISTRATION

ClinicalTrials.gov Reg No. NCT01856179; ClinicalTrials.gov Reg No. NCT01317290.

Authors+Show Affiliations

Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University, Dornburger Straβe 24, 07743, Jena, Germany. b6jage@uni-jena.de.Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University, Dornburger Straβe 24, 07743, Jena, Germany. stefanie.weiss@uni-jena.de.Institute of Clinical Chemistry and Laboratory Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, 07747, Jena, Germany. michael.kiehntopf@med.uni-jena.de.Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University, Dornburger Straβe 24, 07743, Jena, Germany. gerhard.jahreis@uni-jena.de.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26892399

Citation

Kuhnt, Katrin, et al. "Consumption of Echium Oil Increases EPA and DPA in Blood Fractions More Efficiently Compared to Linseed Oil in Humans." Lipids in Health and Disease, vol. 15, 2016, p. 32.
Kuhnt K, Weiβ S, Kiehntopf M, et al. Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans. Lipids Health Dis. 2016;15:32.
Kuhnt, K., Weiβ, S., Kiehntopf, M., & Jahreis, G. (2016). Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans. Lipids in Health and Disease, 15, 32. https://doi.org/10.1186/s12944-016-0199-2
Kuhnt K, et al. Consumption of Echium Oil Increases EPA and DPA in Blood Fractions More Efficiently Compared to Linseed Oil in Humans. Lipids Health Dis. 2016 Feb 18;15:32. PubMed PMID: 26892399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans. AU - Kuhnt,Katrin, AU - Weiβ,Stefanie, AU - Kiehntopf,Michael, AU - Jahreis,Gerhard, Y1 - 2016/02/18/ PY - 2015/08/21/received PY - 2016/02/09/accepted PY - 2016/2/20/entrez PY - 2016/2/20/pubmed PY - 2016/12/15/medline SP - 32 EP - 32 JF - Lipids in health and disease JO - Lipids Health Dis VL - 15 N2 - BACKGROUND: A plant-based strategy to improve long-chain (LC) omega (n)-3 PUFA supply in humans involves dietary supplementation with oils containing α-linolenic acid (ALA) alone or in combination with stearidonic acid (SDA). The study aimed to compare the effects of echium oil (EO) and linseed oil (LO) on LC n-3 PUFA accumulation in blood and on clinical markers. METHODS: In two double-blind, parallel-arm, randomized controlled studies, all volunteers started with 17 g/d run-in oil (2 weeks). Thereafter, subjects received diets enriched in study 1 with EO (5 g ALA + 2 g SDA; n = 59) or in study 2 with LO (5 g ALA; n = 9) daily for 8 weeks. The smaller control groups received fish oil (FO; n = 19) or olive oil (OO; n = 18). Participants were instructed to restrict their dietary n-3 PUFA intake throughout the studies (e.g., no fish). To investigate the influence of age and BMI on the conversion of ALA and SDA as well as clinical markers, the subjects recruited for EO and LO treatment were divided into three subgroups (two age groups 20-35 y; 49-69 y with BMI 18-25 kg/m(2) and one group with older, overweight subjects (age 49-69 y; BMI >25 kg/m(2)). RESULTS: In plasma, red blood cells (RBC), and peripheral blood mononuclear cells (PBMC), EPA and docosapentaenoic acid (DPA) were ~25 % higher following EO compared to LO. Comparing all treatments, the effectiveness of increasing EPA and DPA in plasma, RBC, and PBMC was on average 100:25:10:0 and 100:50:25:0 for FO:EO:LO:OO, respectively. EO led to a lower arachidonic acid/EPA-ratio compared to LO in plasma, RBC, and PBMC. Following EO, final DHA was not greater compared to LO. Higher BMI correlated negatively with increases in plasma EPA and DPA after EO supplementation, but not after LO supplementation. Decreasing effect on plasma LDL-C and serum insulin was greater with EO than with LO. CONCLUSIONS: Daily intake of SDA-containing EO is a better supplement than LO for increasing EPA and DPA in blood. However, neither EO nor LO maintained blood DHA status in the absence of fish/seafood consumption. TRIAL REGISTRATION: ClinicalTrials.gov Reg No. NCT01856179; ClinicalTrials.gov Reg No. NCT01317290. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/26892399/Consumption_of_echium_oil_increases_EPA_and_DPA_in_blood_fractions_more_efficiently_compared_to_linseed_oil_in_humans_ DB - PRIME DP - Unbound Medicine ER -