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High cortisol responders to stress show increased sedation to alcohol compared to low cortisol responders: An alcohol dose-response study.
Pharmacol Biochem Behav. 2016 Apr; 143:65-72.PB

Abstract

AIMS

The present study was designed to examine the relationship between high and low cortisol response to an acute stressful situation and the subjective effects after different doses of alcohol, in healthy social drinkers.

METHOD

Sixty-four subjects (32 men and 32 women) participated in one laboratory session. They performed a modified version of the Trier Social Stress Test (TSST) immediately before consumption of either placebo or alcohol (0.2, 0.4 or 0.8 g/kg). Subjects in each dose group were then divided into high (HCR; n=32) or low (LCR; n=32) cortisol responders. Primary dependent measures were self-report questionnaires of mood.

RESULTS

The HCR reported increased ratings on Sedation on the Biphasic Alcohol Effects Scale (BAES) with increased dose in comparison with the LCR. This increase in sedation also correlated to the increase in cortisol levels.

CONCLUSION

We conclude that a high cortisol response to stress modulates the subjective response to alcohol, dose-dependently. HCR subjects experience increased sedative effects of alcohol after consumption of higher doses of alcohol following stress compared to LCR subjects.

Authors+Show Affiliations

Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, SE 413 45 Gothenburg, Sweden. Electronic address: sejla.brkic@neuro.gu.se.Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, SE 413 45 Gothenburg, Sweden; Beroendekliniken, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden.Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, SE 413 45 Gothenburg, Sweden.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26892758

Citation

Brkic, Sejla, et al. "High Cortisol Responders to Stress Show Increased Sedation to Alcohol Compared to Low Cortisol Responders: an Alcohol Dose-response Study." Pharmacology, Biochemistry, and Behavior, vol. 143, 2016, pp. 65-72.
Brkic S, Söderpalm B, Gordh AS. High cortisol responders to stress show increased sedation to alcohol compared to low cortisol responders: An alcohol dose-response study. Pharmacol Biochem Behav. 2016;143:65-72.
Brkic, S., Söderpalm, B., & Gordh, A. S. (2016). High cortisol responders to stress show increased sedation to alcohol compared to low cortisol responders: An alcohol dose-response study. Pharmacology, Biochemistry, and Behavior, 143, 65-72. https://doi.org/10.1016/j.pbb.2016.02.004
Brkic S, Söderpalm B, Gordh AS. High Cortisol Responders to Stress Show Increased Sedation to Alcohol Compared to Low Cortisol Responders: an Alcohol Dose-response Study. Pharmacol Biochem Behav. 2016;143:65-72. PubMed PMID: 26892758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High cortisol responders to stress show increased sedation to alcohol compared to low cortisol responders: An alcohol dose-response study. AU - Brkic,Sejla, AU - Söderpalm,Bo, AU - Gordh,Anna Söderpalm, Y1 - 2016/02/15/ PY - 2015/06/11/received PY - 2016/01/04/revised PY - 2016/02/12/accepted PY - 2016/2/20/entrez PY - 2016/2/20/pubmed PY - 2016/11/8/medline KW - Alcohol KW - Cortisol response KW - Social drinkers KW - Stress KW - Subjective effects KW - TSST SP - 65 EP - 72 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 143 N2 - AIMS: The present study was designed to examine the relationship between high and low cortisol response to an acute stressful situation and the subjective effects after different doses of alcohol, in healthy social drinkers. METHOD: Sixty-four subjects (32 men and 32 women) participated in one laboratory session. They performed a modified version of the Trier Social Stress Test (TSST) immediately before consumption of either placebo or alcohol (0.2, 0.4 or 0.8 g/kg). Subjects in each dose group were then divided into high (HCR; n=32) or low (LCR; n=32) cortisol responders. Primary dependent measures were self-report questionnaires of mood. RESULTS: The HCR reported increased ratings on Sedation on the Biphasic Alcohol Effects Scale (BAES) with increased dose in comparison with the LCR. This increase in sedation also correlated to the increase in cortisol levels. CONCLUSION: We conclude that a high cortisol response to stress modulates the subjective response to alcohol, dose-dependently. HCR subjects experience increased sedative effects of alcohol after consumption of higher doses of alcohol following stress compared to LCR subjects. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/26892758/High_cortisol_responders_to_stress_show_increased_sedation_to_alcohol_compared_to_low_cortisol_responders:_An_alcohol_dose_response_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(16)30016-8 DB - PRIME DP - Unbound Medicine ER -