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Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity.
Fam Cancer 2016; 15(3):487-91FC

Abstract

Approximately 5-10 % of cutaneous melanoma occurs in kindreds with a hereditary predisposition. Mutations in the CDKN2A gene are found to occur in approximately 20-40 % of these kindreds. The first historical mention of what is now called the familial atypical multiple mole melanoma syndrome appears to be from 1820, with more reports throughout the 1950s, 1960s, and later years. In 1991, Lynch and Fusaro described an association between familial multiple mole melanoma and pancreatic cancer and work continues to elucidate the syndrome's genotypic and phenotypic heterogeneity. Individuals at risk for familial melanoma need periodic screenings. Unfortunately, adequate screening for pancreatic cancer does not currently exist, but pancreatic cancer's prominence in the hereditary setting will hopefully act as a stimulus for development of novel screening measures.

Authors+Show Affiliations

Department of Preventive Medicine, Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA. htlynch@creighton.edu.Department of Preventive Medicine, Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26892865

Citation

Lynch, Henry T., and Trudy G. Shaw. "Familial Atypical Multiple Mole Melanoma (FAMMM) Syndrome: History, Genetics, and Heterogeneity." Familial Cancer, vol. 15, no. 3, 2016, pp. 487-91.
Lynch HT, Shaw TG. Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity. Fam Cancer. 2016;15(3):487-91.
Lynch, H. T., & Shaw, T. G. (2016). Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity. Familial Cancer, 15(3), pp. 487-91. doi:10.1007/s10689-016-9888-2.
Lynch HT, Shaw TG. Familial Atypical Multiple Mole Melanoma (FAMMM) Syndrome: History, Genetics, and Heterogeneity. Fam Cancer. 2016;15(3):487-91. PubMed PMID: 26892865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity. AU - Lynch,Henry T, AU - Shaw,Trudy G, PY - 2016/2/20/entrez PY - 2016/2/20/pubmed PY - 2017/7/18/medline KW - CDKN2A KW - Familial atypical multiple mole melanoma syndrome KW - Hereditary melanoma KW - Pancreatic cancer KW - Skin cancer SP - 487 EP - 91 JF - Familial cancer JO - Fam. Cancer VL - 15 IS - 3 N2 - Approximately 5-10 % of cutaneous melanoma occurs in kindreds with a hereditary predisposition. Mutations in the CDKN2A gene are found to occur in approximately 20-40 % of these kindreds. The first historical mention of what is now called the familial atypical multiple mole melanoma syndrome appears to be from 1820, with more reports throughout the 1950s, 1960s, and later years. In 1991, Lynch and Fusaro described an association between familial multiple mole melanoma and pancreatic cancer and work continues to elucidate the syndrome's genotypic and phenotypic heterogeneity. Individuals at risk for familial melanoma need periodic screenings. Unfortunately, adequate screening for pancreatic cancer does not currently exist, but pancreatic cancer's prominence in the hereditary setting will hopefully act as a stimulus for development of novel screening measures. SN - 1573-7292 UR - https://www.unboundmedicine.com/medline/citation/26892865/Familial_atypical_multiple_mole_melanoma__FAMMM__syndrome:_history_genetics_and_heterogeneity_ L2 - https://doi.org/10.1007/s10689-016-9888-2 DB - PRIME DP - Unbound Medicine ER -