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Candidate genes of idiopathic pulmonary fibrosis: current evidence and research.
Appl Clin Genet 2016; 9:5-13AC

Abstract

Idiopathic pulmonary fibrosis (IPF) is a group of common and lethal forms of idiopathic interstitial pulmonary disease. IPF is characterized by a progressive decline in lung function with a median survival of 2-3 years after diagnosis. Although the pathogenesis of the disease remains unknown, genetic predisposition could play a causal role in IPF. A set of genes have been identified as candidate genes of IPF in the past 20 years. However, the recent technological advances that allow for the analysis of millions of polymorphisms in different subjects have deepened the understanding of the genetic complexity of IPF susceptibility. Genome-wide association studies and whole-genome sequencing continue to reveal the genetic loci associated with IPF risk. In this review, we describe candidate genes on the basis of their functions and aim to gain a better understanding of the genetic basis of IPF. The discovered candidate genes may help to clarify pivotal aspects in the diagnosis, prognosis, and therapies of IPF.

Authors+Show Affiliations

Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, People's Republic of China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, People's Republic of China.Department of Medical Genetics, Nanjing University School of Medicine, Nanjing, People's Republic of China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, People's Republic of China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26893575

Citation

Zhou, Wei, and Yaping Wang. "Candidate Genes of Idiopathic Pulmonary Fibrosis: Current Evidence and Research." The Application of Clinical Genetics, vol. 9, 2016, pp. 5-13.
Zhou W, Wang Y. Candidate genes of idiopathic pulmonary fibrosis: current evidence and research. Appl Clin Genet. 2016;9:5-13.
Zhou, W., & Wang, Y. (2016). Candidate genes of idiopathic pulmonary fibrosis: current evidence and research. The Application of Clinical Genetics, 9, pp. 5-13. doi:10.2147/TACG.S61999.
Zhou W, Wang Y. Candidate Genes of Idiopathic Pulmonary Fibrosis: Current Evidence and Research. Appl Clin Genet. 2016;9:5-13. PubMed PMID: 26893575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Candidate genes of idiopathic pulmonary fibrosis: current evidence and research. AU - Zhou,Wei, AU - Wang,Yaping, Y1 - 2016/02/02/ PY - 2016/2/20/entrez PY - 2016/2/20/pubmed PY - 2016/2/20/medline KW - candidate genes KW - idiopathic pulmonary fibrosis KW - susceptibility SP - 5 EP - 13 JF - The application of clinical genetics JO - Appl Clin Genet VL - 9 N2 - Idiopathic pulmonary fibrosis (IPF) is a group of common and lethal forms of idiopathic interstitial pulmonary disease. IPF is characterized by a progressive decline in lung function with a median survival of 2-3 years after diagnosis. Although the pathogenesis of the disease remains unknown, genetic predisposition could play a causal role in IPF. A set of genes have been identified as candidate genes of IPF in the past 20 years. However, the recent technological advances that allow for the analysis of millions of polymorphisms in different subjects have deepened the understanding of the genetic complexity of IPF susceptibility. Genome-wide association studies and whole-genome sequencing continue to reveal the genetic loci associated with IPF risk. In this review, we describe candidate genes on the basis of their functions and aim to gain a better understanding of the genetic basis of IPF. The discovered candidate genes may help to clarify pivotal aspects in the diagnosis, prognosis, and therapies of IPF. SN - 1178-704X UR - https://www.unboundmedicine.com/medline/citation/26893575/Candidate_genes_of_idiopathic_pulmonary_fibrosis:_current_evidence_and_research_ L2 - https://dx.doi.org/10.2147/TACG.S61999 DB - PRIME DP - Unbound Medicine ER -