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Hepatitis E virus: An ancient hidden enemy in Latin America.
World J Gastroenterol. 2016 Feb 21; 22(7):2271-83.WJ

Abstract

Hepatitis E virus (HEV) infection is a common cause of acute clinical hepatitis worldwide. HEV is an RNA-containing virus and the only member of the genus Hepevirus in the family Hepeviridae. Human HEV is classified into four genotypes widely distributed across the world. The virus is mainly transmitted via the fecal-oral route, and water-borne epidemics have become characteristic of hepatitis E in developing countries, including those in Latin America. The zoonotic potential of HEV is broadly recognized. Thus, there is an urgent need to re-evaluate virus transmission scenarios and to enforce epidemiological surveillance systems. Additionally, it is known that HEV infections, initially defined as self-limiting, can also take chronic courses in immunocompromised patients. Moreover, we recently reported a high seroprevalence of HEV in samples from cirrhotic patients with no other etiological agents present, suggesting the potential role of HEV in the development of chronic liver illness. In this review, HEV genomic variability, transmission, chronic infectious course, zoonotic potential and treatment are discussed. Focus is placed on the impact of HEV infection in Latin America, to support the development of specific control strategies and the handling of this important and typically imperceptible viral infection.

Authors+Show Affiliations

Nora A Fierro, Immunovirology Unit, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Department of Physiology, Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, México.Nora A Fierro, Immunovirology Unit, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Department of Physiology, Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, México.Nora A Fierro, Immunovirology Unit, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Department of Physiology, Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, México.Nora A Fierro, Immunovirology Unit, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Department of Physiology, Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, México.Nora A Fierro, Immunovirology Unit, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Department of Physiology, Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, México.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26900289

Citation

Fierro, Nora A., et al. "Hepatitis E Virus: an Ancient Hidden Enemy in Latin America." World Journal of Gastroenterology, vol. 22, no. 7, 2016, pp. 2271-83.
Fierro NA, Realpe M, Meraz-Medina T, et al. Hepatitis E virus: An ancient hidden enemy in Latin America. World J Gastroenterol. 2016;22(7):2271-83.
Fierro, N. A., Realpe, M., Meraz-Medina, T., Roman, S., & Panduro, A. (2016). Hepatitis E virus: An ancient hidden enemy in Latin America. World Journal of Gastroenterology, 22(7), 2271-83. https://doi.org/10.3748/wjg.v22.i7.2271
Fierro NA, et al. Hepatitis E Virus: an Ancient Hidden Enemy in Latin America. World J Gastroenterol. 2016 Feb 21;22(7):2271-83. PubMed PMID: 26900289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E virus: An ancient hidden enemy in Latin America. AU - Fierro,Nora A, AU - Realpe,Mauricio, AU - Meraz-Medina,Tzintli, AU - Roman,Sonia, AU - Panduro,Arturo, PY - 2015/07/21/received PY - 2015/10/21/revised PY - 2015/12/30/accepted PY - 2016/2/23/entrez PY - 2016/2/24/pubmed PY - 2017/1/18/medline KW - Emerging diseases KW - Hepatitis E virus-chronic infection KW - Mexico KW - Viral genotypes KW - Zoonosis SP - 2271 EP - 83 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 22 IS - 7 N2 - Hepatitis E virus (HEV) infection is a common cause of acute clinical hepatitis worldwide. HEV is an RNA-containing virus and the only member of the genus Hepevirus in the family Hepeviridae. Human HEV is classified into four genotypes widely distributed across the world. The virus is mainly transmitted via the fecal-oral route, and water-borne epidemics have become characteristic of hepatitis E in developing countries, including those in Latin America. The zoonotic potential of HEV is broadly recognized. Thus, there is an urgent need to re-evaluate virus transmission scenarios and to enforce epidemiological surveillance systems. Additionally, it is known that HEV infections, initially defined as self-limiting, can also take chronic courses in immunocompromised patients. Moreover, we recently reported a high seroprevalence of HEV in samples from cirrhotic patients with no other etiological agents present, suggesting the potential role of HEV in the development of chronic liver illness. In this review, HEV genomic variability, transmission, chronic infectious course, zoonotic potential and treatment are discussed. Focus is placed on the impact of HEV infection in Latin America, to support the development of specific control strategies and the handling of this important and typically imperceptible viral infection. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/26900289/Hepatitis_E_virus:_An_ancient_hidden_enemy_in_Latin_America_ L2 - https://www.wjgnet.com/1007-9327/full/v22/i7/2271.htm DB - PRIME DP - Unbound Medicine ER -