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Cisapride in gastro-oesophageal reflux disease: effects on oesophageal motility and intra-oesophageal pH.
Scand J Gastroenterol Suppl 1989; 165:13-8; discussion 27-8SJ

Abstract

Since gastro-oesophageal reflux disease is due to disturbances of oesophageal motility, motor and pH measurements are an important means to test a new anti-reflux drug, cisapride. In oesophageal manometry cisapride increased the pressure of the lower oesophageal sphincter in healthy volunteers and patients, and in the majority of studies it also strengthened the amplitude of oesophageal contractions. Cisapride lowered the total duration of acid exposure in the lower oesophagus in both volunteers and reflux patients. Thus cisapride may be useful in the treatment of gastro-oesophageal reflux disease.

Authors+Show Affiliations

Dept. of Internal Medicine III, Zentralklinikum, Augsburg, F.R.G.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

2690320

Citation

Wienbeck, M, and Q Li. "Cisapride in Gastro-oesophageal Reflux Disease: Effects On Oesophageal Motility and Intra-oesophageal PH." Scandinavian Journal of Gastroenterology. Supplement, vol. 165, 1989, pp. 13-8; discussion 27-8.
Wienbeck M, Li Q. Cisapride in gastro-oesophageal reflux disease: effects on oesophageal motility and intra-oesophageal pH. Scand J Gastroenterol Suppl. 1989;165:13-8; discussion 27-8.
Wienbeck, M., & Li, Q. (1989). Cisapride in gastro-oesophageal reflux disease: effects on oesophageal motility and intra-oesophageal pH. Scandinavian Journal of Gastroenterology. Supplement, 165, pp. 13-8; discussion 27-8.
Wienbeck M, Li Q. Cisapride in Gastro-oesophageal Reflux Disease: Effects On Oesophageal Motility and Intra-oesophageal PH. Scand J Gastroenterol Suppl. 1989;165:13-8; discussion 27-8. PubMed PMID: 2690320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cisapride in gastro-oesophageal reflux disease: effects on oesophageal motility and intra-oesophageal pH. AU - Wienbeck,M, AU - Li,Q, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 13-8; discussion 27-8 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand. J. Gastroenterol. Suppl. VL - 165 N2 - Since gastro-oesophageal reflux disease is due to disturbances of oesophageal motility, motor and pH measurements are an important means to test a new anti-reflux drug, cisapride. In oesophageal manometry cisapride increased the pressure of the lower oesophageal sphincter in healthy volunteers and patients, and in the majority of studies it also strengthened the amplitude of oesophageal contractions. Cisapride lowered the total duration of acid exposure in the lower oesophagus in both volunteers and reflux patients. Thus cisapride may be useful in the treatment of gastro-oesophageal reflux disease. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/2690320/Cisapride_in_gastro_oesophageal_reflux_disease:_effects_on_oesophageal_motility_and_intra_oesophageal_pH_ L2 - https://medlineplus.gov/gerd.html DB - PRIME DP - Unbound Medicine ER -