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Efficacy of cisapride on symptoms and healing of gastro-oesophageal reflux disease: a review.

Abstract

Cisapride is a new drug which stimulates gastrointestinal motility via facilitation of acetylcholine release from myenteric nerves. European studies have addressed its clinical efficacy in treating gastro-oesophageal reflux disease in three areas. 1) Symptom relief: Cisapride, usually at a dose of 10 mg t.i.d., was superior to placebo and metoclopramide in relief of daytime and night-time heartburn and regurgitation. 2) Healing oesophagitis: Six studies showed that cisapride 10 mg q.i.d effectively heals oesophagitis over 6-16 weeks. Cisapride was superior to placebo and as effective as H2-antagonists in healing grades I-III oesophagitis. Combination therapy with H2-antagonists may be superior to H2-blocker alone. 3) Paediatric efficacy: Cisapride 1 mg/kg/day was effective in the treatment of infants and children with oesophagitis and pulmonary symptoms related to acid reflux. In conclusion, cisapride offers a promising alternative for the treatment of gastrooesophageal reflux disease without the troubling side effects of existing promotility drugs.

Authors+Show Affiliations

Gastroenterology Section, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27103.

Source

Scandinavian journal of gastroenterology. Supplement 165: 1989 pg 19-27; discussion 27-8

MeSH

Adult
Child
Cisapride
Clinical Trials as Topic
Dose-Response Relationship, Drug
Double-Blind Method
Esophagitis, Peptic
Gastroesophageal Reflux
Humans
Piperidines
Serotonin Antagonists
Wound Healing

Pub Type(s)

Clinical Trial
Journal Article
Review

Language

eng

PubMed ID

2690321

Citation

Richter, J E.. "Efficacy of Cisapride On Symptoms and Healing of Gastro-oesophageal Reflux Disease: a Review." Scandinavian Journal of Gastroenterology. Supplement, vol. 165, 1989, pp. 19-27; discussion 27-8.
Richter JE. Efficacy of cisapride on symptoms and healing of gastro-oesophageal reflux disease: a review. Scand J Gastroenterol Suppl. 1989;165:19-27; discussion 27-8.
Richter, J. E. (1989). Efficacy of cisapride on symptoms and healing of gastro-oesophageal reflux disease: a review. Scandinavian Journal of Gastroenterology. Supplement, 165, pp. 19-27; discussion 27-8.
Richter JE. Efficacy of Cisapride On Symptoms and Healing of Gastro-oesophageal Reflux Disease: a Review. Scand J Gastroenterol Suppl. 1989;165:19-27; discussion 27-8. PubMed PMID: 2690321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of cisapride on symptoms and healing of gastro-oesophageal reflux disease: a review. A1 - Richter,J E, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 19-27; discussion 27-8 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand. J. Gastroenterol. Suppl. VL - 165 N2 - Cisapride is a new drug which stimulates gastrointestinal motility via facilitation of acetylcholine release from myenteric nerves. European studies have addressed its clinical efficacy in treating gastro-oesophageal reflux disease in three areas. 1) Symptom relief: Cisapride, usually at a dose of 10 mg t.i.d., was superior to placebo and metoclopramide in relief of daytime and night-time heartburn and regurgitation. 2) Healing oesophagitis: Six studies showed that cisapride 10 mg q.i.d effectively heals oesophagitis over 6-16 weeks. Cisapride was superior to placebo and as effective as H2-antagonists in healing grades I-III oesophagitis. Combination therapy with H2-antagonists may be superior to H2-blocker alone. 3) Paediatric efficacy: Cisapride 1 mg/kg/day was effective in the treatment of infants and children with oesophagitis and pulmonary symptoms related to acid reflux. In conclusion, cisapride offers a promising alternative for the treatment of gastrooesophageal reflux disease without the troubling side effects of existing promotility drugs. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/2690321/Efficacy_of_cisapride_on_symptoms_and_healing_of_gastro_oesophageal_reflux_disease:_a_review_ L2 - https://medlineplus.gov/gerd.html DB - PRIME DP - Unbound Medicine ER -