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Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats.
J Toxicol. 2016; 2016:9507563.JT

Abstract

Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein (DIA) on DOX-induced nephrotoxicity. DIA (25 and 50 mg/kg/day) was administered orally to rats for 15 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of DOX (15 mg/kg) at the 11th day. We measured levels of serum urea, creatinine, renal reduced glutathione (GSH), malondialdehyde (MDA), total nitrites (NO x), catalase, and superoxide dismutase (SOD). In addition, caspase-3, tumor necrosis factor alpha (TNFα), nuclear factor kappa B (NFκB) expressions, and renal histopathology were assessed. Our results showed that DOX-induced nephrotoxicity was ameliorated or reduced by both doses of DIA, but diacerein high dose (DHD) showed more improvement than diacerein low dose (DLD). This protective effect was manifested by significant improvement in all measured parameters compared to DOX treated group by using DHD. DLD showed significant improvement of creatinine, MDA, NO x , GSH, histopathology, and immunohistochemical parameters compared to DOX treated group.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, El-Minia University, El-Minia 61111, Egypt.Department of Pharmacology, Faculty of Medicine, El-Minia University, El-Minia 61111, Egypt.Department of Histology, Faculty of Medicine, El-Minia University, El-Minia 61111, Egypt.Department of Pharmacology, Faculty of Medicine, El-Minia University, El-Minia 61111, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26904117

Citation

Refaie, Marwa M M., et al. "Possible Protective Effect of Diacerein On Doxorubicin-Induced Nephrotoxicity in Rats." Journal of Toxicology, vol. 2016, 2016, p. 9507563.
Refaie MM, Amin EF, El-Tahawy NF, et al. Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats. J Toxicol. 2016;2016:9507563.
Refaie, M. M., Amin, E. F., El-Tahawy, N. F., & Abdelrahman, A. M. (2016). Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats. Journal of Toxicology, 2016, 9507563. https://doi.org/10.1155/2016/9507563
Refaie MM, et al. Possible Protective Effect of Diacerein On Doxorubicin-Induced Nephrotoxicity in Rats. J Toxicol. 2016;2016:9507563. PubMed PMID: 26904117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats. AU - Refaie,Marwa M M, AU - Amin,Entesar F, AU - El-Tahawy,Nashwa F, AU - Abdelrahman,Aly M, Y1 - 2016/01/20/ PY - 2015/10/24/received PY - 2015/12/21/revised PY - 2015/12/28/accepted PY - 2016/2/24/entrez PY - 2016/2/24/pubmed PY - 2016/2/24/medline SP - 9507563 EP - 9507563 JF - Journal of toxicology JO - J Toxicol VL - 2016 N2 - Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein (DIA) on DOX-induced nephrotoxicity. DIA (25 and 50 mg/kg/day) was administered orally to rats for 15 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of DOX (15 mg/kg) at the 11th day. We measured levels of serum urea, creatinine, renal reduced glutathione (GSH), malondialdehyde (MDA), total nitrites (NO x), catalase, and superoxide dismutase (SOD). In addition, caspase-3, tumor necrosis factor alpha (TNFα), nuclear factor kappa B (NFκB) expressions, and renal histopathology were assessed. Our results showed that DOX-induced nephrotoxicity was ameliorated or reduced by both doses of DIA, but diacerein high dose (DHD) showed more improvement than diacerein low dose (DLD). This protective effect was manifested by significant improvement in all measured parameters compared to DOX treated group by using DHD. DLD showed significant improvement of creatinine, MDA, NO x , GSH, histopathology, and immunohistochemical parameters compared to DOX treated group. SN - 1687-8191 UR - https://www.unboundmedicine.com/medline/citation/26904117/Possible_Protective_Effect_of_Diacerein_on_Doxorubicin_Induced_Nephrotoxicity_in_Rats_ L2 - https://doi.org/10.1155/2016/9507563 DB - PRIME DP - Unbound Medicine ER -
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