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Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide.
Oxid Med Cell Longev 2016; 2016:4723416OM

Abstract

Hydrogen sulfide (H2S) is a well-known environmental chemical threat with an unpleasant smell of rotten eggs. Aside from the established toxic effects of high-dose H2S, research over the past decade revealed that cells endogenously produce small amounts of H2S with physiological functions. H2S has therefore been classified as a "gasotransmitter." A major challenge for cells and tissues is the maintenance of low physiological concentrations of H2S in order to prevent potential toxicity. Epithelia of the respiratory and gastrointestinal tract are especially faced with this problem, since these barriers are predominantly exposed to exogenous H2S from environmental sources or sulfur-metabolising microbiota. In this paper, we review the cellular mechanisms by which epithelial cells maintain physiological, endogenous H2S concentrations. Furthermore, we suggest a concept by which epithelia use their electrolyte and liquid transport machinery as defence mechanisms in order to eliminate exogenous sources for potentially harmful H2S concentrations.

Authors+Show Affiliations

Institute for Veterinary Physiology and Biochemistry, Justus-Liebig University, Frankfurter Strasse 100, 35392 Giessen, Germany.Institute for Animal Physiology, Justus-Liebig University, Heinrich-Buff-Ring 26, 35392 Giessen, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26904165

Citation

Pouokam, Ervice, and Mike Althaus. "Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide." Oxidative Medicine and Cellular Longevity, vol. 2016, 2016, p. 4723416.
Pouokam E, Althaus M. Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide. Oxid Med Cell Longev. 2016;2016:4723416.
Pouokam, E., & Althaus, M. (2016). Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide. Oxidative Medicine and Cellular Longevity, 2016, p. 4723416. doi:10.1155/2016/4723416.
Pouokam E, Althaus M. Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide. Oxid Med Cell Longev. 2016;2016:4723416. PubMed PMID: 26904165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide. AU - Pouokam,Ervice, AU - Althaus,Mike, Y1 - 2016/01/20/ PY - 2015/10/29/received PY - 2015/12/17/accepted PY - 2016/2/24/entrez PY - 2016/2/24/pubmed PY - 2016/12/15/medline SP - 4723416 EP - 4723416 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2016 N2 - Hydrogen sulfide (H2S) is a well-known environmental chemical threat with an unpleasant smell of rotten eggs. Aside from the established toxic effects of high-dose H2S, research over the past decade revealed that cells endogenously produce small amounts of H2S with physiological functions. H2S has therefore been classified as a "gasotransmitter." A major challenge for cells and tissues is the maintenance of low physiological concentrations of H2S in order to prevent potential toxicity. Epithelia of the respiratory and gastrointestinal tract are especially faced with this problem, since these barriers are predominantly exposed to exogenous H2S from environmental sources or sulfur-metabolising microbiota. In this paper, we review the cellular mechanisms by which epithelial cells maintain physiological, endogenous H2S concentrations. Furthermore, we suggest a concept by which epithelia use their electrolyte and liquid transport machinery as defence mechanisms in order to eliminate exogenous sources for potentially harmful H2S concentrations. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/26904165/Epithelial_Electrolyte_Transport_Physiology_and_the_Gasotransmitter_Hydrogen_Sulfide_ L2 - https://dx.doi.org/10.1155/2016/4723416 DB - PRIME DP - Unbound Medicine ER -