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Effects of coffee consumption on serum uric acid: systematic review and meta-analysis.
Semin Arthritis Rheum. 2016 Apr; 45(5):580-6.SA

Abstract

OBJECTIVE

Study results on the effects of coffee consumption on serum uric acid (UA) have been conflicting. The aim of this study is to analyze the literature regarding the effect of coffee consumption on serum UA.

METHODS

We searched MEDLINE, EMBASE, the Cochrane library, and KoreaMed for all articles published before January 2015. Studies with quantitative data on coffee consumption and serum UA level were included. Coffee consumption and serum UA level were identified with/without the risk of gout.

RESULTS

Nine studies published between 1999 and 2014 were included, containing a total of 175,310 subjects. Meta-analysis demonstrated that coffee has a significantly lowering effect on serum UA, where there are gender differences in the amount of coffee required to lower serum UA. Women (4-6 cups/day) need more coffee to lower serum UA than men (1-3 cups/day). Meta-analysis showed that coffee intake of 1 cup/day or more was significantly associated with reduction of the risk of gout, with a negative correlation with the amount of daily coffee intake for both genders.

CONCLUSIONS

This is the first systematic review on the effects of coffee consumption on serum UA. Based on our study, moderate coffee intake might be advocated for primary prevention of hyperuricemia and gout in both genders.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Park KY
Department of Physical Medicine and Rehabilitation, Ajou University School of Medicine, Worldcup-ro 164, Yeongtong-gu, Suwon 16499, Republic of Korea.
Kim HJ
Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
Ahn HS
Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
Kim SH
Department of Physical Medicine and Rehabilitation, Ajou University School of Medicine, Worldcup-ro 164, Yeongtong-gu, Suwon 16499, Republic of Korea.
Park EJ
Department of Physical Medicine and Rehabilitation, Ajou University School of Medicine, Worldcup-ro 164, Yeongtong-gu, Suwon 16499, Republic of Korea.
Yim SY
Department of Physical Medicine and Rehabilitation, Ajou University School of Medicine, Worldcup-ro 164, Yeongtong-gu, Suwon 16499, Republic of Korea. Electronic address: syyim@ajou.ac.kr.
Jun JB
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222-1, Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. Electronic address: junjb@hanyang.ac.kr.

MeSH

CoffeeFemaleGoutHumansHyperuricemiaMaleSex FactorsUric Acid

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

26905267

Citation

Park, Kyu Yong, et al. "Effects of Coffee Consumption On Serum Uric Acid: Systematic Review and Meta-analysis." Seminars in Arthritis and Rheumatism, vol. 45, no. 5, 2016, pp. 580-6.
Park KY, Kim HJ, Ahn HS, et al. Effects of coffee consumption on serum uric acid: systematic review and meta-analysis. Semin Arthritis Rheum. 2016;45(5):580-6.
Park, K. Y., Kim, H. J., Ahn, H. S., Kim, S. H., Park, E. J., Yim, S. Y., & Jun, J. B. (2016). Effects of coffee consumption on serum uric acid: systematic review and meta-analysis. Seminars in Arthritis and Rheumatism, 45(5), 580-6. https://doi.org/10.1016/j.semarthrit.2016.01.003
Park KY, et al. Effects of Coffee Consumption On Serum Uric Acid: Systematic Review and Meta-analysis. Semin Arthritis Rheum. 2016;45(5):580-6. PubMed PMID: 26905267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of coffee consumption on serum uric acid: systematic review and meta-analysis. AU - Park,Kyu Yong, AU - Kim,Hyun Jung, AU - Ahn,Hyeong Sik, AU - Kim,Sun Hee, AU - Park,Eun Ji, AU - Yim,Shin-Young, AU - Jun,Jae-Bum, Y1 - 2016/01/21/ PY - 2015/10/01/received PY - 2015/11/30/revised PY - 2016/01/15/accepted PY - 2016/2/25/entrez PY - 2016/2/26/pubmed PY - 2016/12/31/medline KW - Beverages KW - Caffeine KW - Coffee KW - Gout KW - Hyperuricemia KW - Uric acid SP - 580 EP - 6 JF - Seminars in arthritis and rheumatism JO - Semin Arthritis Rheum VL - 45 IS - 5 N2 - OBJECTIVE: Study results on the effects of coffee consumption on serum uric acid (UA) have been conflicting. The aim of this study is to analyze the literature regarding the effect of coffee consumption on serum UA. METHODS: We searched MEDLINE, EMBASE, the Cochrane library, and KoreaMed for all articles published before January 2015. Studies with quantitative data on coffee consumption and serum UA level were included. Coffee consumption and serum UA level were identified with/without the risk of gout. RESULTS: Nine studies published between 1999 and 2014 were included, containing a total of 175,310 subjects. Meta-analysis demonstrated that coffee has a significantly lowering effect on serum UA, where there are gender differences in the amount of coffee required to lower serum UA. Women (4-6 cups/day) need more coffee to lower serum UA than men (1-3 cups/day). Meta-analysis showed that coffee intake of 1 cup/day or more was significantly associated with reduction of the risk of gout, with a negative correlation with the amount of daily coffee intake for both genders. CONCLUSIONS: This is the first systematic review on the effects of coffee consumption on serum UA. Based on our study, moderate coffee intake might be advocated for primary prevention of hyperuricemia and gout in both genders. SN - 1532-866X UR - https://www.unboundmedicine.com/medline/citation/26905267/Effects_of_coffee_consumption_on_serum_uric_acid:_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -