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The influence of aerosol retention and pattern of deposition on bronchial responsiveness to atropine and methacholine in humans.
Am Rev Respir Dis. 1989 Dec; 140(6):1727-33.AR

Abstract

We have examined the influence of total intrapulmonary deposition and its pattern on the bronchial response to aerosolized methacholine and atropine in 10 normal and 12 asthmatic subjects. On Day 1 we performed a dose-response challenge to methacholine and defined responsiveness as the provocative dose (PD35) needed to cause a 35% decrease in specific airway conductance (SGaw). On Day 2 we repeated methacholine challenge after premedication with aerosolized atropine, and we defined the response to atropine as dose ratio-1 (DR-1) where DR = PD35 after atropine/PD35 without atropine. On Day 3 we imaged intrapulmonary aerosol deposition by mixing 99mtechnetium with methacholine aerosol and scanning the thorax with a gamma camera during the development of bronchoconstriction. Total pulmonary aerosol deposition varied considerably between individuals (1.2 to 23.6% of nebulized dose) but there was no difference between normal and asthmatic subjects, and no correlation between deposition and baseline SGaw or PD35; there was a significant positive correlation between deposition and DR-1. Deposition of aerosol in central lung zones was inversely related to SGaw and correlated positively with DR-1; there was no significant relationship with PD35. Total intrapulmonary aerosol deposition and its pattern partially determine bronchial responsiveness to atropine, but we have not demonstrated any significant effect on responsiveness to methacholine.

Authors+Show Affiliations

Department of Medicine, Charing Cross and Westminster Medical School, London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2690707

Citation

Gillett, M K., et al. "The Influence of Aerosol Retention and Pattern of Deposition On Bronchial Responsiveness to Atropine and Methacholine in Humans." The American Review of Respiratory Disease, vol. 140, no. 6, 1989, pp. 1727-33.
Gillett MK, Briggs BA, Snashall PD. The influence of aerosol retention and pattern of deposition on bronchial responsiveness to atropine and methacholine in humans. Am Rev Respir Dis. 1989;140(6):1727-33.
Gillett, M. K., Briggs, B. A., & Snashall, P. D. (1989). The influence of aerosol retention and pattern of deposition on bronchial responsiveness to atropine and methacholine in humans. The American Review of Respiratory Disease, 140(6), 1727-33.
Gillett MK, Briggs BA, Snashall PD. The Influence of Aerosol Retention and Pattern of Deposition On Bronchial Responsiveness to Atropine and Methacholine in Humans. Am Rev Respir Dis. 1989;140(6):1727-33. PubMed PMID: 2690707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of aerosol retention and pattern of deposition on bronchial responsiveness to atropine and methacholine in humans. AU - Gillett,M K, AU - Briggs,B A, AU - Snashall,P D, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 1727 EP - 33 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 140 IS - 6 N2 - We have examined the influence of total intrapulmonary deposition and its pattern on the bronchial response to aerosolized methacholine and atropine in 10 normal and 12 asthmatic subjects. On Day 1 we performed a dose-response challenge to methacholine and defined responsiveness as the provocative dose (PD35) needed to cause a 35% decrease in specific airway conductance (SGaw). On Day 2 we repeated methacholine challenge after premedication with aerosolized atropine, and we defined the response to atropine as dose ratio-1 (DR-1) where DR = PD35 after atropine/PD35 without atropine. On Day 3 we imaged intrapulmonary aerosol deposition by mixing 99mtechnetium with methacholine aerosol and scanning the thorax with a gamma camera during the development of bronchoconstriction. Total pulmonary aerosol deposition varied considerably between individuals (1.2 to 23.6% of nebulized dose) but there was no difference between normal and asthmatic subjects, and no correlation between deposition and baseline SGaw or PD35; there was a significant positive correlation between deposition and DR-1. Deposition of aerosol in central lung zones was inversely related to SGaw and correlated positively with DR-1; there was no significant relationship with PD35. Total intrapulmonary aerosol deposition and its pattern partially determine bronchial responsiveness to atropine, but we have not demonstrated any significant effect on responsiveness to methacholine. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/2690707/The_influence_of_aerosol_retention_and_pattern_of_deposition_on_bronchial_responsiveness_to_atropine_and_methacholine_in_humans_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/140.6.1727?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -