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The Toxicity of Aluminum Chloride on Kidney of Rats.

Abstract

This study investigated the toxicity of aluminum chloride (AlCl3) exposure in the rat kidney. Forty male Wistar rats (5 weeks old), weighing 110-120 g, were randomly divided into four groups: control group (CG, 0 g/L AlCl3), low dose group (LG, 0.4 g/L AlCl3), mid dose group (MG, 0.8 g/L AlCl3), and high dose group (HG, 1.6 g/L AlCl3). Rats were administered AlCl3 in their drinking water for 120 days. A variety of measurements were taken including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities, malondialdehyde (MDA) concentration in the kidney and blood urea nitrogen (BUN), and cystatin C (Cys-C) concentrations in the serum. In addition, Al and β2-microglobulin (β2-MG) concentrations and the activity of N-acetyl-β-D-glucosaminidase (NAG) in the urine were determined. The results showed that in the AlCl3-treated groups SOD and GSH-PX activities were decreased, while NAG activity and Al, MDA, BUN, Cys-C, and β2-MG concentrations were increased, compared with the CG. This study indicates that AlCl3 exposure induces oxidative stress and suppresses kidney function.

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  • Authors+Show Affiliations

    ,

    College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. Police Dog Technical School of Ministry of Public Security, Shenyang, 110034, China.

    ,

    Province Key Laboratory of Forest Protection, Liaoning Academy of Forest Science, Shenyang, 110034, China.

    ,

    College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

    ,

    College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

    ,

    College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

    ,

    College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

    ,

    College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

    College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. 403535036@qq.com.

    Source

    Biological trace element research 173:2 2016 Oct pg 339-44

    MeSH

    Aluminum Compounds
    Animals
    Chlorides
    Dose-Response Relationship, Drug
    Gene Expression Regulation, Enzymologic
    Glutathione Peroxidase
    Kidney
    Male
    Malondialdehyde
    Oxidative Stress
    Rats
    Rats, Wistar
    Superoxide Dismutase

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26910335

    Citation

    TY - JOUR T1 - The Toxicity of Aluminum Chloride on Kidney of Rats. AU - Liu,Jianyu, AU - Wang,Qin, AU - Sun,Xudong, AU - Yang,Xu, AU - Zhuang,Cuicui, AU - Xu,Feibo, AU - Cao,Zheng, AU - Li,Yanfei, Y1 - 2016/02/24/ PY - 2015/12/13/received PY - 2016/02/12/accepted PY - 2016/2/25/entrez PY - 2016/2/26/pubmed PY - 2017/1/20/medline KW - AlCl3 KW - Kidney KW - Oxidative stress KW - Rats KW - Toxicity SP - 339 EP - 44 JF - Biological trace element research JO - Biol Trace Elem Res VL - 173 IS - 2 N2 - This study investigated the toxicity of aluminum chloride (AlCl3) exposure in the rat kidney. Forty male Wistar rats (5 weeks old), weighing 110-120 g, were randomly divided into four groups: control group (CG, 0 g/L AlCl3), low dose group (LG, 0.4 g/L AlCl3), mid dose group (MG, 0.8 g/L AlCl3), and high dose group (HG, 1.6 g/L AlCl3). Rats were administered AlCl3 in their drinking water for 120 days. A variety of measurements were taken including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities, malondialdehyde (MDA) concentration in the kidney and blood urea nitrogen (BUN), and cystatin C (Cys-C) concentrations in the serum. In addition, Al and β2-microglobulin (β2-MG) concentrations and the activity of N-acetyl-β-D-glucosaminidase (NAG) in the urine were determined. The results showed that in the AlCl3-treated groups SOD and GSH-PX activities were decreased, while NAG activity and Al, MDA, BUN, Cys-C, and β2-MG concentrations were increased, compared with the CG. This study indicates that AlCl3 exposure induces oxidative stress and suppresses kidney function. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/26910335/The_Toxicity_of_Aluminum_Chloride_on_Kidney_of_Rats_ L2 - https://dx.doi.org/10.1007/s12011-016-0648-9 ER -