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The Role of Long Noncoding RNAs in Neurodegenerative Diseases.
Mol Neurobiol. 2017 04; 54(3):2012-2021.MN

Abstract

Long noncoding RNAs (lncRNAs) are transcripts with low protein-coding potential but occupy a large part of transcriptional output. Their roles include regulating gene expression at the epigenetic, transcriptional, and post-transcriptional level in cellular homeostasis. However, lncRNA studies are still in their infancy and the functions of the vast majority of lncRNA transcripts remain unknown. It is generally known that the function of the human nervous system largely relies on the precise regulation of gene expression. Various studies have shown that lncRNAs have a significant impact on normal neural development and on the development and progression of neurodegenerative diseases. In this review, we focused on recent studies associated with lncRNAs in neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), frontotemporal lobar degeneration (FTLD), and glaucoma. Glaucoma, caused by unexplained ganglion cell lesion and apoptosis, is now labeled as a chronic neurodegenerative disorder [1], and therefore, we discussed the association of lncRNAs with glaucoma as well. We illustrate the role of some specific lncRNAs, which may provide new insights into our understanding of the etiology and pathophysiology of the neurodegenerative diseases mentioned above.

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, Guangdong, People's Republic of China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, Guangdong, People's Republic of China. swrth@163.com.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, Guangdong, People's Republic of China. zhuoyh@mail.sysu.edu.cn.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26910817

Citation

Wan, Peixing, et al. "The Role of Long Noncoding RNAs in Neurodegenerative Diseases." Molecular Neurobiology, vol. 54, no. 3, 2017, pp. 2012-2021.
Wan P, Su W, Zhuo Y. The Role of Long Noncoding RNAs in Neurodegenerative Diseases. Mol Neurobiol. 2017;54(3):2012-2021.
Wan, P., Su, W., & Zhuo, Y. (2017). The Role of Long Noncoding RNAs in Neurodegenerative Diseases. Molecular Neurobiology, 54(3), 2012-2021. https://doi.org/10.1007/s12035-016-9793-6
Wan P, Su W, Zhuo Y. The Role of Long Noncoding RNAs in Neurodegenerative Diseases. Mol Neurobiol. 2017;54(3):2012-2021. PubMed PMID: 26910817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Long Noncoding RNAs in Neurodegenerative Diseases. AU - Wan,Peixing, AU - Su,Wenru, AU - Zhuo,Yehong, Y1 - 2016/02/24/ PY - 2015/11/24/received PY - 2016/02/11/accepted PY - 2016/2/26/pubmed PY - 2018/2/8/medline PY - 2016/2/25/entrez KW - Alzheimer’s disease (AD) KW - Amyotrophic lateral sclerosis (ALS) KW - Frontotemporal lobar degeneration (FTLD) KW - Glaucoma KW - Huntington’s disease (HD) KW - Long noncoding RNAs (lncRNAs) KW - Multiple system atrophy (MSA) KW - Neurodegenerative diseases KW - Parkinson’s disease (PD) SP - 2012 EP - 2021 JF - Molecular neurobiology JO - Mol Neurobiol VL - 54 IS - 3 N2 - Long noncoding RNAs (lncRNAs) are transcripts with low protein-coding potential but occupy a large part of transcriptional output. Their roles include regulating gene expression at the epigenetic, transcriptional, and post-transcriptional level in cellular homeostasis. However, lncRNA studies are still in their infancy and the functions of the vast majority of lncRNA transcripts remain unknown. It is generally known that the function of the human nervous system largely relies on the precise regulation of gene expression. Various studies have shown that lncRNAs have a significant impact on normal neural development and on the development and progression of neurodegenerative diseases. In this review, we focused on recent studies associated with lncRNAs in neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), frontotemporal lobar degeneration (FTLD), and glaucoma. Glaucoma, caused by unexplained ganglion cell lesion and apoptosis, is now labeled as a chronic neurodegenerative disorder [1], and therefore, we discussed the association of lncRNAs with glaucoma as well. We illustrate the role of some specific lncRNAs, which may provide new insights into our understanding of the etiology and pathophysiology of the neurodegenerative diseases mentioned above. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/26910817/The_Role_of_Long_Noncoding_RNAs_in_Neurodegenerative_Diseases_ L2 - https://dx.doi.org/10.1007/s12035-016-9793-6 DB - PRIME DP - Unbound Medicine ER -