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Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis.
Vet Anaesth Analg. 2016 Nov; 43(6):643-651.VA

Abstract

OBJECTIVE

To evaluate the analgesic efficacy of meloxicam oral transmucosal spray (OTMS) alone and with tramadol in cats with osteoarthritis (OA).

STUDY DESIGN

Randomized, blinded study.

ANIMALS

Fifteen geriatric cats weighing 4.5 ± 1.0 kg.

METHODS

Healthy cats with OA were randomly administered a placebo (every 12 hours orally) and meloxicam OTMS (approximately 0.05 mg kg-1 every 24 hours) (group M, n = 7), or tramadol (3 mg kg-1 every 12 hours orally) and meloxicam OTMS (group TM, n = 8) for 25 days. Evaluations performed before treatment (D0) and at week 3 (W3) consisted of peak vertical force, motor activity and response to mechanical temporal summation of pain (RMTS). Data were analyzed with mixed models and Fisher's exact test.

RESULTS

Mean ± standard deviation peak vertical force (percentage of body weight) increased significantly in both groups (p = 0.02), from 47.7 ± 6.5% to 60.5 ± 9.4% in group M, and from 51.8 ± 5.0% to 64.1 ± 6.5% in group TM, with no difference between groups. Motor activity increased in M (from 43 ± 12 to 56 ± 13; p = 0.02), but not in TM. The number of stimulations from RMTS increased in TM only. Cut-off values were reached in a larger number of cats (n = 5) in TM than M (n = 1) (p < 0.05). Gastrointestinal adverse effects were self-limiting in six cats, including five in TM.

CONCLUSIONS AND CLINICAL RELEVANCE

Meloxicam OTMS had similar effects on peak vertical force, motor activity and pain sensitization as previously reported for oral meloxicam in OA cats. The tramadol-meloxicam combination provided no evident benefit over meloxicam alone, except for central hypersensitivity (assessed with RMTS). Further assessment of the potential toxicity of the combination is required prior to clinical use. Gingival administration was well accepted overall.

Authors+Show Affiliations

Animal Pharmacology Research Group of Quebec (GREPAQ), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.Animal Pharmacology Research Group of Quebec (GREPAQ), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada. Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.Animal Pharmacology Research Group of Quebec (GREPAQ), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada. Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.Animal Pharmacology Research Group of Quebec (GREPAQ), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada. Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.US Veterinary Operations, Zoetis, Inc., Florham Park, NJ, USA.Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada.Animal Pharmacology Research Group of Quebec (GREPAQ), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.Animal Pharmacology Research Group of Quebec (GREPAQ), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.Animal Pharmacology Research Group of Quebec (GREPAQ), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada. eric.troncy@umontreal.ca. Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada. eric.troncy@umontreal.ca.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26913836

Citation

Monteiro, Beatriz P., et al. "Analgesic Efficacy of an Oral Transmucosal Spray Formulation of Meloxicam Alone or in Combination With Tramadol in Cats With Naturally Occurring Osteoarthritis." Veterinary Anaesthesia and Analgesia, vol. 43, no. 6, 2016, pp. 643-651.
Monteiro BP, Klinck MP, Moreau M, et al. Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis. Vet Anaesth Analg. 2016;43(6):643-651.
Monteiro, B. P., Klinck, M. P., Moreau, M., Guillot, M., Steagall, P. V., Edge, D. K., Pelletier, J. P., Martel-Pelletier, J., Gauvin, D., Del Castillo, J. R., & Troncy, E. (2016). Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis. Veterinary Anaesthesia and Analgesia, 43(6), 643-651. https://doi.org/10.1111/vaa.12360
Monteiro BP, et al. Analgesic Efficacy of an Oral Transmucosal Spray Formulation of Meloxicam Alone or in Combination With Tramadol in Cats With Naturally Occurring Osteoarthritis. Vet Anaesth Analg. 2016;43(6):643-651. PubMed PMID: 26913836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis. AU - Monteiro,Beatriz P, AU - Klinck,Mary P, AU - Moreau,Maxim, AU - Guillot,Martin, AU - Steagall,Paulo Vm, AU - Edge,Daniel K, AU - Pelletier,Jean-Pierre, AU - Martel-Pelletier,Johanne, AU - Gauvin,Dominique, AU - Del Castillo,Jérôme Re, AU - Troncy,Eric, Y1 - 2016/02/24/ PY - 2015/07/05/received PY - 2015/12/26/accepted PY - 2016/2/26/pubmed PY - 2017/4/5/medline PY - 2016/2/26/entrez KW - analgesia KW - degenerative joint disease KW - feline chronic pain KW - meloxicam KW - osteoarthritis KW - tramadol SP - 643 EP - 651 JF - Veterinary anaesthesia and analgesia JO - Vet Anaesth Analg VL - 43 IS - 6 N2 - OBJECTIVE: To evaluate the analgesic efficacy of meloxicam oral transmucosal spray (OTMS) alone and with tramadol in cats with osteoarthritis (OA). STUDY DESIGN: Randomized, blinded study. ANIMALS: Fifteen geriatric cats weighing 4.5 ± 1.0 kg. METHODS: Healthy cats with OA were randomly administered a placebo (every 12 hours orally) and meloxicam OTMS (approximately 0.05 mg kg-1 every 24 hours) (group M, n = 7), or tramadol (3 mg kg-1 every 12 hours orally) and meloxicam OTMS (group TM, n = 8) for 25 days. Evaluations performed before treatment (D0) and at week 3 (W3) consisted of peak vertical force, motor activity and response to mechanical temporal summation of pain (RMTS). Data were analyzed with mixed models and Fisher's exact test. RESULTS: Mean ± standard deviation peak vertical force (percentage of body weight) increased significantly in both groups (p = 0.02), from 47.7 ± 6.5% to 60.5 ± 9.4% in group M, and from 51.8 ± 5.0% to 64.1 ± 6.5% in group TM, with no difference between groups. Motor activity increased in M (from 43 ± 12 to 56 ± 13; p = 0.02), but not in TM. The number of stimulations from RMTS increased in TM only. Cut-off values were reached in a larger number of cats (n = 5) in TM than M (n = 1) (p < 0.05). Gastrointestinal adverse effects were self-limiting in six cats, including five in TM. CONCLUSIONS AND CLINICAL RELEVANCE: Meloxicam OTMS had similar effects on peak vertical force, motor activity and pain sensitization as previously reported for oral meloxicam in OA cats. The tramadol-meloxicam combination provided no evident benefit over meloxicam alone, except for central hypersensitivity (assessed with RMTS). Further assessment of the potential toxicity of the combination is required prior to clinical use. Gingival administration was well accepted overall. SN - 1467-2995 UR - https://www.unboundmedicine.com/medline/citation/26913836/Analgesic_efficacy_of_an_oral_transmucosal_spray_formulation_of_meloxicam_alone_or_in_combination_with_tramadol_in_cats_with_naturally_occurring_osteoarthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1467-2987(16)30026-5 DB - PRIME DP - Unbound Medicine ER -