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In vivo, micro-morphological vascular changes induced by topical brimonidine studied by Dynamic optical coherence tomography.
J Eur Acad Dermatol Venereol. 2016 Jun; 30(6):974-9.JE

Abstract

BACKGROUND

Brimonidine is a selective α2 adrenergic receptor agonist with potent vasoconstrictive activity topically used for treatment of facial flushing and erythema caused by rosacea. Direct evidence for the in vivo morphology changes in skin vessels induced by topical application of brimonidine is limited. Dynamic optical coherence tomography is a novel technology that combines conventional OCT with information on flow and thereby provides supplementary information about the microvasculature. Dynamic OCT is non-invasive and creates high-resolution in vivo images of skin to a depth of maximum 2 mm.

OBJECTIVE

The objective of this study was to examine and describe micro-morphological skin vessel changes in normal skin exposed to brimonidine gel using Dynamic OCT.

MATERIALS AND METHODS

A total of 35 healthy subjects from three European clinical dermatology centres were included in the study. A normal skin area on the cheek was marked and clinically photographed. Brimonidine gel 0.33% was applied on the area and chromaticity measurements; laser speckle measurements and Dynamic OCT images were acquired at baseline and 60 min after application. The images were subsequently described in detail and quantitatively analysed.

RESULTS

All the measurement tools (chromaticity, laser speckle, Dynamic OCT showed highly significant (P < 0.001) quantitative differences in blood flow before and after the application of brimonidine. In 58% of the subjects the Dynamic OCT images showed notable changes in the morphology of the blood vessel network after application of brimonidine including a marked reduction in the abundance and the diameter of the blood vessels.

CONCLUSION

The vascular constriction induced by topical brimonidine gel 0.33% was visualized in vivo by Dynamic OCT and confirmed by quantitative measurements and analyses. This study shows that Dynamic OCT can detect characteristic morphological changes in the vessels and may potentially aid the monitoring of treatment effects on skin vessels following topical or laser treatment.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Themstrup L
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark.
Ciardo S
Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
Manfredi M
Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, Modena, Italy.
Ulrich M
CMB/Collegium Medicum Berlin, Berlin, Germany.
Pellacani G
Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
Welzel J
Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, Germany.
Jemec GB
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark.

MeSH

Administration, OphthalmicAdrenergic alpha-2 Receptor AgonistsAdultBrimonidine TartrateFemaleHumansMaleMiddle AgedTomography, Optical CoherenceYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26916576

Clinical Trial Links

Skin Imaging to Inform Laser Treatments

Citation

Themstrup, L, et al. "In Vivo, Micro-morphological Vascular Changes Induced By Topical Brimonidine Studied By Dynamic Optical Coherence Tomography." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 30, no. 6, 2016, pp. 974-9.
Themstrup L, Ciardo S, Manfredi M, et al. In vivo, micro-morphological vascular changes induced by topical brimonidine studied by Dynamic optical coherence tomography. J Eur Acad Dermatol Venereol. 2016;30(6):974-9.
Themstrup, L., Ciardo, S., Manfredi, M., Ulrich, M., Pellacani, G., Welzel, J., & Jemec, G. B. (2016). In vivo, micro-morphological vascular changes induced by topical brimonidine studied by Dynamic optical coherence tomography. Journal of the European Academy of Dermatology and Venereology : JEADV, 30(6), 974-9. https://doi.org/10.1111/jdv.13596
Themstrup L, et al. In Vivo, Micro-morphological Vascular Changes Induced By Topical Brimonidine Studied By Dynamic Optical Coherence Tomography. J Eur Acad Dermatol Venereol. 2016;30(6):974-9. PubMed PMID: 26916576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo, micro-morphological vascular changes induced by topical brimonidine studied by Dynamic optical coherence tomography. AU - Themstrup,L, AU - Ciardo,S, AU - Manfredi,M, AU - Ulrich,M, AU - Pellacani,G, AU - Welzel,J, AU - Jemec,G B E, Y1 - 2016/02/25/ PY - 2015/09/11/received PY - 2015/11/14/revised PY - 2015/12/10/accepted PY - 2016/2/27/entrez PY - 2016/2/27/pubmed PY - 2017/4/27/medline SP - 974 EP - 9 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 30 IS - 6 N2 - BACKGROUND: Brimonidine is a selective α2 adrenergic receptor agonist with potent vasoconstrictive activity topically used for treatment of facial flushing and erythema caused by rosacea. Direct evidence for the in vivo morphology changes in skin vessels induced by topical application of brimonidine is limited. Dynamic optical coherence tomography is a novel technology that combines conventional OCT with information on flow and thereby provides supplementary information about the microvasculature. Dynamic OCT is non-invasive and creates high-resolution in vivo images of skin to a depth of maximum 2 mm. OBJECTIVE: The objective of this study was to examine and describe micro-morphological skin vessel changes in normal skin exposed to brimonidine gel using Dynamic OCT. MATERIALS AND METHODS: A total of 35 healthy subjects from three European clinical dermatology centres were included in the study. A normal skin area on the cheek was marked and clinically photographed. Brimonidine gel 0.33% was applied on the area and chromaticity measurements; laser speckle measurements and Dynamic OCT images were acquired at baseline and 60 min after application. The images were subsequently described in detail and quantitatively analysed. RESULTS: All the measurement tools (chromaticity, laser speckle, Dynamic OCT showed highly significant (P < 0.001) quantitative differences in blood flow before and after the application of brimonidine. In 58% of the subjects the Dynamic OCT images showed notable changes in the morphology of the blood vessel network after application of brimonidine including a marked reduction in the abundance and the diameter of the blood vessels. CONCLUSION: The vascular constriction induced by topical brimonidine gel 0.33% was visualized in vivo by Dynamic OCT and confirmed by quantitative measurements and analyses. This study shows that Dynamic OCT can detect characteristic morphological changes in the vessels and may potentially aid the monitoring of treatment effects on skin vessels following topical or laser treatment. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/26916576/In_vivo_micro_morphological_vascular_changes_induced_by_topical_brimonidine_studied_by_Dynamic_optical_coherence_tomography_ DB - PRIME DP - Unbound Medicine ER -