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Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis.
J Dent Res. 2016 06; 95(6):635-41.JD

Abstract

We previously reported a systemic hyperinflammatory response to bacterial lipopolysaccharide (LPS) in children with localized aggressive periodontitis (LAP). Additionally, different levels of this response were observed within the LAP group. It is unknown whether this hyperinflammatory response influences the clinical response to periodontal treatment in these children. Therefore, the goal of this study was to evaluate the influence of LPS responsiveness present prior to treatment on the clinical response to treatment within the LAP cohort. Prior to treatment, peripheral blood was collected from 60 African American participants aged 5 to 21 y, free of systemic diseases, and diagnosed with LAP. Blood was stimulated with ultrapure LPS from Escherichia coli, and Luminex assays were performed to quantify 14 cytokine/chemokine levels. Principal component and cluster analyses were used to find patterns of cytokine/chemokine expression among participants and subdivide them into clusters. Three distinct clusters emerged among LAP participants: a high responder group (high level of response for INFg, IL6, and IL12p40), a mixed responder group (low for some and high for other cytokines/chemokines), and a low responder group (low overall cytokine/chemokine response). Periodontal clinical parameters were compared among these groups prior to and 3, 6, and 12 mo following treatment with mechanical debridement and systemic antibiotics. High responders presented the lowest reductions in clinical parameters after treatment, whereas the low responders presented the highest reductions. In our LAP participants, distinct patterns of LPS response were significantly predictive of changes in clinical parameters after treatment. Future studies are needed to evaluate the underlying mechanisms predicting the heterogeneity of LAP activity, severity, and response to treatment (ClinicalTrials.gov NCT01330719).

Authors+Show Affiliations

Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA.Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.Department of Periodontology, University of Florida College of Dentistry, Gainesville, FL, USA Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA lshaddox@dental.ufl.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26917438

Citation

Allin, N, et al. "Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis." Journal of Dental Research, vol. 95, no. 6, 2016, pp. 635-41.
Allin N, Cruz-Almeida Y, Velsko I, et al. Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. J Dent Res. 2016;95(6):635-41.
Allin, N., Cruz-Almeida, Y., Velsko, I., Vovk, A., Hovemcamp, N., Harrison, P., Huang, H., Aukhil, I., Wallet, S. M., & Shaddox, L. M. (2016). Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. Journal of Dental Research, 95(6), 635-41. https://doi.org/10.1177/0022034516631973
Allin N, et al. Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. J Dent Res. 2016;95(6):635-41. PubMed PMID: 26917438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. AU - Allin,N, AU - Cruz-Almeida,Y, AU - Velsko,I, AU - Vovk,A, AU - Hovemcamp,N, AU - Harrison,P, AU - Huang,H, AU - Aukhil,I, AU - Wallet,S M, AU - Shaddox,L M, Y1 - 2016/02/25/ PY - 2016/2/27/entrez PY - 2016/2/27/pubmed PY - 2017/5/23/medline KW - chemokines KW - cytokines KW - inflammation KW - lipopolysaccharides KW - periodontal diseases KW - therapy SP - 635 EP - 41 JF - Journal of dental research JO - J. Dent. Res. VL - 95 IS - 6 N2 - We previously reported a systemic hyperinflammatory response to bacterial lipopolysaccharide (LPS) in children with localized aggressive periodontitis (LAP). Additionally, different levels of this response were observed within the LAP group. It is unknown whether this hyperinflammatory response influences the clinical response to periodontal treatment in these children. Therefore, the goal of this study was to evaluate the influence of LPS responsiveness present prior to treatment on the clinical response to treatment within the LAP cohort. Prior to treatment, peripheral blood was collected from 60 African American participants aged 5 to 21 y, free of systemic diseases, and diagnosed with LAP. Blood was stimulated with ultrapure LPS from Escherichia coli, and Luminex assays were performed to quantify 14 cytokine/chemokine levels. Principal component and cluster analyses were used to find patterns of cytokine/chemokine expression among participants and subdivide them into clusters. Three distinct clusters emerged among LAP participants: a high responder group (high level of response for INFg, IL6, and IL12p40), a mixed responder group (low for some and high for other cytokines/chemokines), and a low responder group (low overall cytokine/chemokine response). Periodontal clinical parameters were compared among these groups prior to and 3, 6, and 12 mo following treatment with mechanical debridement and systemic antibiotics. High responders presented the lowest reductions in clinical parameters after treatment, whereas the low responders presented the highest reductions. In our LAP participants, distinct patterns of LPS response were significantly predictive of changes in clinical parameters after treatment. Future studies are needed to evaluate the underlying mechanisms predicting the heterogeneity of LAP activity, severity, and response to treatment (ClinicalTrials.gov NCT01330719). SN - 1544-0591 UR - https://www.unboundmedicine.com/medline/citation/26917438/Inflammatory_Response_Influences_Treatment_of_Localized_Aggressive_Periodontitis_ L2 - http://journals.sagepub.com/doi/full/10.1177/0022034516631973?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -