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Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a single centre study of a cohort of 164 patients.
Rheumatology (Oxford) 2016; 55(6):1023-30R

Abstract

OBJECTIVE

The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome.

METHODS

We recruited all patients presenting to Peking Union Medical College Hospital from 2004 to 2015 diagnosed with SAPHO syndrome. The medical data, laboratory test results and imaging were collected for all patients.

RESULTS

One hundred and sixty-four patients (111 women and 53 men) were recruited to our cohort. The mean age of the patients was 40.71 years. Nine patients had osteoarticular symptoms without skin involvement. One hundred and forty-three and 25 patients had palmoplantar pustulosis and severe acne, respectively. Psoriasis vulgaris was accompanied by palmoplantar pustulosis or severe acne in 24 patients. One hundred and sixty-four patients suffered from pain in the anterior chest wall, followed by spine (12 in the cervical region, 36 in the thoracic region and 111 in the lumbosacral region) and peripheral joint (136 patients) involvement. None of the patients had IBD. The hs-CRP level was increased in 70.8% patients. Only 2.4% were HLA-B27 positive. CT scan indicated osteolysis, sclerosis and hyperostosis in the anterior chest wall and spine in SAPHO syndrome patients. The bull-horn sign was the typical characteristic of SAPHO syndrome seen in bone scintigraphy images. One hundred and thirty-one (79.9%), 85 (51.8%), 100 (61%) and 54 (32.9%) patients took NSAIDs, CSs, DMARDs and oral bisphosphonates, respectively.

CONCLUSION

SAPHO syndrome is predominant in middle-age women, characterized by dermatological and osteoarticular manifestations with unknown aetiology. CT scan and bone scintigraphy are useful for diagnosis. There is still no standard treatment to control the disease.

Authors+Show Affiliations

Department of Traditional Chinese Medicine.Department of Orthopedic Surgery.Department of Orthopedic Surgery.Department of Dermatology.Department of Dermatology.Department of Radiology.Department of Radiology.Department of Radiology.Department of Nuclear Medicine.Department of Nuclear Medicine.Department of Pathology.Department of Pathology.Department of Orthopedic Surgery.Department of Orthopedic Surgery.Department of Orthopedic Surgery.Department of Orthopedic Surgery.Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology and.Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology and.Department of Traditional Chinese Medicine.Department of Orthopedic Surgery.Department of Orthopedic Surgery, Department of Central Laboratory, Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. China.Department of Traditional Chinese Medicine.Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, zhangwen91@sina.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26917545

Citation

Li, Chen, et al. "Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis Syndrome: a Single Centre Study of a Cohort of 164 Patients." Rheumatology (Oxford, England), vol. 55, no. 6, 2016, pp. 1023-30.
Li C, Zuo Y, Wu N, et al. Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a single centre study of a cohort of 164 patients. Rheumatology (Oxford). 2016;55(6):1023-30.
Li, C., Zuo, Y., Wu, N., Li, L., Li, F., Zhang, W., ... Zhang, W. (2016). Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a single centre study of a cohort of 164 patients. Rheumatology (Oxford, England), 55(6), pp. 1023-30. doi:10.1093/rheumatology/kew015.
Li C, et al. Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis Syndrome: a Single Centre Study of a Cohort of 164 Patients. Rheumatology (Oxford). 2016;55(6):1023-30. PubMed PMID: 26917545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a single centre study of a cohort of 164 patients. AU - Li,Chen, AU - Zuo,Yuzhi, AU - Wu,Nan, AU - Li,Li, AU - Li,Feng, AU - Zhang,Weihong, AU - Xu,Wenrui, AU - Zhao,Xue, AU - Jing,Hongli, AU - Pan,Qingqing, AU - Zhou,Weixun, AU - Shi,Xiaohua, AU - Fan,Yu, AU - Wang,Jianyi, AU - Liu,Sen, AU - Liu,Zhenlei, AU - Zhang,Fengchun, AU - Zeng,Xiaofeng, AU - Chen,Hui, AU - Zhang,Siya, AU - Liu,Jinhe, AU - Qiu,Guixing, AU - Wu,Zhihong, AU - Dong,Zhenhua, AU - Zhang,Wen, Y1 - 2016/02/25/ PY - 2015/08/19/received PY - 2016/2/27/entrez PY - 2016/2/27/pubmed PY - 2017/6/13/medline KW - SAPHO syndrome KW - clinic and radiologic features KW - treatment SP - 1023 EP - 30 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 55 IS - 6 N2 - OBJECTIVE: The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome. METHODS: We recruited all patients presenting to Peking Union Medical College Hospital from 2004 to 2015 diagnosed with SAPHO syndrome. The medical data, laboratory test results and imaging were collected for all patients. RESULTS: One hundred and sixty-four patients (111 women and 53 men) were recruited to our cohort. The mean age of the patients was 40.71 years. Nine patients had osteoarticular symptoms without skin involvement. One hundred and forty-three and 25 patients had palmoplantar pustulosis and severe acne, respectively. Psoriasis vulgaris was accompanied by palmoplantar pustulosis or severe acne in 24 patients. One hundred and sixty-four patients suffered from pain in the anterior chest wall, followed by spine (12 in the cervical region, 36 in the thoracic region and 111 in the lumbosacral region) and peripheral joint (136 patients) involvement. None of the patients had IBD. The hs-CRP level was increased in 70.8% patients. Only 2.4% were HLA-B27 positive. CT scan indicated osteolysis, sclerosis and hyperostosis in the anterior chest wall and spine in SAPHO syndrome patients. The bull-horn sign was the typical characteristic of SAPHO syndrome seen in bone scintigraphy images. One hundred and thirty-one (79.9%), 85 (51.8%), 100 (61%) and 54 (32.9%) patients took NSAIDs, CSs, DMARDs and oral bisphosphonates, respectively. CONCLUSION: SAPHO syndrome is predominant in middle-age women, characterized by dermatological and osteoarticular manifestations with unknown aetiology. CT scan and bone scintigraphy are useful for diagnosis. There is still no standard treatment to control the disease. SN - 1462-0332 UR - https://www.unboundmedicine.com/medline/citation/26917545/Synovitis_acne_pustulosis_hyperostosis_and_osteitis_syndrome:_a_single_centre_study_of_a_cohort_of_164_patients_ L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kew015 DB - PRIME DP - Unbound Medicine ER -