Tags

Type your tag names separated by a space and hit enter

Graphene Paper Decorated with a 2D Array of Dendritic Platinum Nanoparticles for Ultrasensitive Electrochemical Detection of Dopamine Secreted by Live Cells.
Chemistry. 2016 Apr 04; 22(15):5204-10.C

Abstract

To circumvent the bottlenecks of non-flexibility, low sensitivity, and narrow workable detection range of conventional biosensors for biological molecule detection (e.g., dopamine (DA) secreted by living cells), a new hybrid flexible electrochemical biosensor has been created by decorating closely packed dendritic Pt nanoparticles (NPs) on freestanding graphene paper. This innovative structural integration of ultrathin graphene paper and uniform 2D arrays of dendritic NPs by tailored wet chemical synthesis has been achieved by a modular strategy through a facile and delicately controlled oil-water interfacial assembly method, whereby the uniform distribution of catalytic dendritic NPs on the graphene paper is maximized. In this way, the performance is improved by several orders of magnitude. The developed hybrid electrode shows a high sensitivity of 2 μA cm(-2) μM(-1), up to about 33 times higher than those of conventional sensors, a low detection limit of 5 nM, and a wide linear range of 87 nM to 100 μM. These combined features enable the ultrasensitive detection of DA released from pheochromocytoma (PC 12) cells. The unique features of this flexible sensor can be attributed to the well-tailored uniform 2D array of dendritic Pt NPs and the modular electrode assembly at the oil-water interface. Its excellent performance holds much promise for the future development of optimized flexible electrochemical sensors for a diverse range of electroactive molecules to better serve society.

Authors+Show Affiliations

School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore. School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.Energy Research Institute@NTU, Nanyang Technological University, Singapore, 637753, Singapore. hwbai@ntu.edu.sg.School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore.School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore. hwduan@ntu.edu.sg.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26918612

Citation

Zan, Xiaoli, et al. "Graphene Paper Decorated With a 2D Array of Dendritic Platinum Nanoparticles for Ultrasensitive Electrochemical Detection of Dopamine Secreted By Live Cells." Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 22, no. 15, 2016, pp. 5204-10.
Zan X, Bai H, Wang C, et al. Graphene Paper Decorated with a 2D Array of Dendritic Platinum Nanoparticles for Ultrasensitive Electrochemical Detection of Dopamine Secreted by Live Cells. Chemistry. 2016;22(15):5204-10.
Zan, X., Bai, H., Wang, C., Zhao, F., & Duan, H. (2016). Graphene Paper Decorated with a 2D Array of Dendritic Platinum Nanoparticles for Ultrasensitive Electrochemical Detection of Dopamine Secreted by Live Cells. Chemistry (Weinheim an Der Bergstrasse, Germany), 22(15), 5204-10. https://doi.org/10.1002/chem.201504454
Zan X, et al. Graphene Paper Decorated With a 2D Array of Dendritic Platinum Nanoparticles for Ultrasensitive Electrochemical Detection of Dopamine Secreted By Live Cells. Chemistry. 2016 Apr 4;22(15):5204-10. PubMed PMID: 26918612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Graphene Paper Decorated with a 2D Array of Dendritic Platinum Nanoparticles for Ultrasensitive Electrochemical Detection of Dopamine Secreted by Live Cells. AU - Zan,Xiaoli, AU - Bai,Hongwei, AU - Wang,Chenxu, AU - Zhao,Faqiong, AU - Duan,Hongwei, Y1 - 2016/02/25/ PY - 2015/11/05/received PY - 2016/2/27/entrez PY - 2016/2/27/pubmed PY - 2016/8/25/medline KW - dopamine KW - graphene KW - living cells KW - platinum KW - sensors SP - 5204 EP - 10 JF - Chemistry (Weinheim an der Bergstrasse, Germany) JO - Chemistry VL - 22 IS - 15 N2 - To circumvent the bottlenecks of non-flexibility, low sensitivity, and narrow workable detection range of conventional biosensors for biological molecule detection (e.g., dopamine (DA) secreted by living cells), a new hybrid flexible electrochemical biosensor has been created by decorating closely packed dendritic Pt nanoparticles (NPs) on freestanding graphene paper. This innovative structural integration of ultrathin graphene paper and uniform 2D arrays of dendritic NPs by tailored wet chemical synthesis has been achieved by a modular strategy through a facile and delicately controlled oil-water interfacial assembly method, whereby the uniform distribution of catalytic dendritic NPs on the graphene paper is maximized. In this way, the performance is improved by several orders of magnitude. The developed hybrid electrode shows a high sensitivity of 2 μA cm(-2) μM(-1), up to about 33 times higher than those of conventional sensors, a low detection limit of 5 nM, and a wide linear range of 87 nM to 100 μM. These combined features enable the ultrasensitive detection of DA released from pheochromocytoma (PC 12) cells. The unique features of this flexible sensor can be attributed to the well-tailored uniform 2D array of dendritic Pt NPs and the modular electrode assembly at the oil-water interface. Its excellent performance holds much promise for the future development of optimized flexible electrochemical sensors for a diverse range of electroactive molecules to better serve society. SN - 1521-3765 UR - https://www.unboundmedicine.com/medline/citation/26918612/Graphene_Paper_Decorated_with_a_2D_Array_of_Dendritic_Platinum_Nanoparticles_for_Ultrasensitive_Electrochemical_Detection_of_Dopamine_Secreted_by_Live_Cells_ L2 - https://doi.org/10.1002/chem.201504454 DB - PRIME DP - Unbound Medicine ER -