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A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong.
Virol Sin. 2016 Feb; 31(1):41-8.VS

Abstract

We conducted a six-year epidemiological study on human coronaviruses (HCoVs) circulating in Hong Kong, using 8275 nasopharyngeal samples from patients with acute respiratory tract infections. HCoVs were detected in 77 (0.93%) of the samples by a pan-HCoV RT-PCR assay. The most frequently detected HCoV species was HCoV-OC43 (0.58%), followed by HCoV-229E (0.15%), HCoV-HKU1 (0.13%) and HCoV-NL63 (0.07%). HCoVs were detected throughout the study period (September 2008-August 2014), with the highest detection rate from September 2010 to August 2011 (22/1500, 1.47%). Different seasonal patterns of each HCoV species in Hong Kong were noted. HCoV-OC43 was predominant in the fall and winter, whereas HCoV-HKU1 showed peak activity in winter, with a few cases occurred in spring and summer. HCoV-229E mainly occurred in winter and spring, while HCoV-NL63 was predominant in summer and autumn. HCoVs most commonly infect the elderly and young children, with median age of 79.5 years (range, 22 days to 95 years). Intriguingly, the detection rate of HCoV-OC43 in the age group of > 80 years (26/2380, 1.09%) was significantly higher than that in the age group of 0-10 years (12/2529, 0.47%) (P < 0.05). These data provides new insight into the epidemiology of coronaviruses.

Authors+Show Affiliations

Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.Department of Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China.Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China.Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China. Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong SAR, China. State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, China.Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China. skplau@hku.hk. Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong SAR, China. skplau@hku.hk. State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, China. skplau@hku.hk.Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China. pcywoo@hku.hk. Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong SAR, China. pcywoo@hku.hk. State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, China. pcywoo@hku.hk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26920709

Citation

Yip, Cyril C Y., et al. "A Six-year Descriptive Epidemiological Study of Human Coronavirus Infections in Hospitalized Patients in Hong Kong." Virologica Sinica, vol. 31, no. 1, 2016, pp. 41-8.
Yip CC, Lam CS, Luk HK, et al. A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong. Virol Sin. 2016;31(1):41-8.
Yip, C. C., Lam, C. S., Luk, H. K., Wong, E. Y., Lee, R. A., So, L. Y., Chan, K. H., Cheng, V. C., Yuen, K. Y., Woo, P. C., & Lau, S. K. (2016). A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong. Virologica Sinica, 31(1), 41-8. https://doi.org/10.1007/s12250-016-3714-8
Yip CC, et al. A Six-year Descriptive Epidemiological Study of Human Coronavirus Infections in Hospitalized Patients in Hong Kong. Virol Sin. 2016;31(1):41-8. PubMed PMID: 26920709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong. AU - Yip,Cyril C Y, AU - Lam,Carol S F, AU - Luk,Hayes K H, AU - Wong,Emily Y M, AU - Lee,Rodney A, AU - So,Lok-Yee, AU - Chan,Kwok-Hung, AU - Cheng,Vincent C C, AU - Yuen,Kwok-Yung, AU - Woo,Patrick C Y, AU - Lau,Susanna K P, Y1 - 2016/02/23/ PY - 2016/01/04/received PY - 2016/02/11/accepted PY - 2016/2/28/entrez PY - 2016/2/28/pubmed PY - 2016/12/15/medline KW - epidemiology KW - human coronaviruses KW - respiratory tract infections SP - 41 EP - 8 JF - Virologica Sinica JO - Virol Sin VL - 31 IS - 1 N2 - We conducted a six-year epidemiological study on human coronaviruses (HCoVs) circulating in Hong Kong, using 8275 nasopharyngeal samples from patients with acute respiratory tract infections. HCoVs were detected in 77 (0.93%) of the samples by a pan-HCoV RT-PCR assay. The most frequently detected HCoV species was HCoV-OC43 (0.58%), followed by HCoV-229E (0.15%), HCoV-HKU1 (0.13%) and HCoV-NL63 (0.07%). HCoVs were detected throughout the study period (September 2008-August 2014), with the highest detection rate from September 2010 to August 2011 (22/1500, 1.47%). Different seasonal patterns of each HCoV species in Hong Kong were noted. HCoV-OC43 was predominant in the fall and winter, whereas HCoV-HKU1 showed peak activity in winter, with a few cases occurred in spring and summer. HCoV-229E mainly occurred in winter and spring, while HCoV-NL63 was predominant in summer and autumn. HCoVs most commonly infect the elderly and young children, with median age of 79.5 years (range, 22 days to 95 years). Intriguingly, the detection rate of HCoV-OC43 in the age group of > 80 years (26/2380, 1.09%) was significantly higher than that in the age group of 0-10 years (12/2529, 0.47%) (P < 0.05). These data provides new insight into the epidemiology of coronaviruses. SN - 1995-820X UR - https://www.unboundmedicine.com/medline/citation/26920709/A_six_year_descriptive_epidemiological_study_of_human_coronavirus_infections_in_hospitalized_patients_in_Hong_Kong_ L2 - https://dx.doi.org/10.1007/s12250-016-3714-8 DB - PRIME DP - Unbound Medicine ER -