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Anti-NMDA-R encephalitis: Should we consider extreme delta brush as electrical status epilepticus?
Neurophysiol Clin. 2016 Feb; 46(1):17-25.NC

Abstract

Seizures are common clinical manifestations in anti-N-methyl-d-aspartate receptor (anti-NMDA-R) encephalitis, among other neurological and psychiatric symptoms. During the course of the disease, some specific EEG patterns have been described: generalized rhythmic delta activity (GRDA) and extreme delta brush (EDB). In comatose patients, the association of these EEG abnormalities with subtle motor manifestations can suggest ongoing non-convulsive status epilepticus (NCSE). We report the case of a 28-year-old woman admitted for a clinical presentation typical of anti-NMDA-R encephalitis, which was confirmed by CSF analysis. She was rapidly intubated because of severe dysautonomia and disturbed consciousness. Clinical examination revealed subtle paroxysmal and intermittent myoclonic and tonic movements, correlated on video-EEG with GRDA and/or EDB. NCSE was then suspected, but electroclinical manifestations persisted despite many anti-epileptic drugs combinations, or reappeared when barbiturate anesthesia was decreased. In order to confirm or dismiss the diagnosis, intracranial pressure (ICP) and surface video-EEG monitoring were performed simultaneously and revealed no ICP increase, thus being strongly against a diagnosis of seizures. Sedation was progressively weaned, and clinical condition as well as EEG appearance progressively improved. Literature review revealed 11 similar cases, including 2 with focal NCSE. Of the nine other cases, NCSE diagnosis was finally excluded in 5 cases. NCSE diagnosis in association with anti-NMDA-R encephalitis is sometimes very difficult and its occurrence might be overestimated. Video-EEG is highly recommended and more invasive techniques may sometimes be necessary.

Authors+Show Affiliations

Service de neurologie et unité de neurophysiologie clinique, CHU Gabriel-Montpied, 63000 Clermont-Ferrand, France. Electronic address: eve.chanson@hotmail.fr.Service de neurologie et unité de neurophysiologie clinique, CHU Gabriel-Montpied, 63000 Clermont-Ferrand, France.Service de neurologie et unité de neurophysiologie clinique, CHU Gabriel-Montpied, 63000 Clermont-Ferrand, France.Service de neuroreanimation, CHU Gabriel-Montpied, 63000 Clermont-Ferrand, France.Service de neuroreanimation, CHU Gabriel-Montpied, 63000 Clermont-Ferrand, France.Centre de référence des syndromes paranéoplasique, hôpital neurologique, hospices civils de Lyon, 69677 Bron, France; Lyon Neuroscience Research Center, Inserm U1028/CNRS UMR 5292, 69372 Lyon, France.Centre de référence des syndromes paranéoplasique, hôpital neurologique, hospices civils de Lyon, 69677 Bron, France; Lyon Neuroscience Research Center, Inserm U1028/CNRS UMR 5292, 69372 Lyon, France.Service de neurologie et unité de neurophysiologie clinique, CHU Gabriel-Montpied, 63000 Clermont-Ferrand, France; UMR 1107, NeuroDol, université d'Auvergne, 63000 Clermont-Ferrand, France.Service de neurologie et unité de neurophysiologie clinique, CHU Gabriel-Montpied, 63000 Clermont-Ferrand, France; EA 7282, IGCNC (Image-Guided Clinical Neuroscience and Connectomics), UMR 6284 ISIT, UFR médecine, université d'Auvergne, 63000 Clermont-Ferrand, France.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

26922283

Citation

Chanson, Eve, et al. "Anti-NMDA-R Encephalitis: Should We Consider Extreme Delta Brush as Electrical Status Epilepticus?" Neurophysiologie Clinique = Clinical Neurophysiology, vol. 46, no. 1, 2016, pp. 17-25.
Chanson E, Bicilli É, Lauxerois M, et al. Anti-NMDA-R encephalitis: Should we consider extreme delta brush as electrical status epilepticus? Neurophysiol Clin. 2016;46(1):17-25.
Chanson, E., Bicilli, É., Lauxerois, M., Kauffmann, S., Chabanne, R., Ducray, F., Honnorat, J., Clavelou, P., & Rosenberg, S. (2016). Anti-NMDA-R encephalitis: Should we consider extreme delta brush as electrical status epilepticus? Neurophysiologie Clinique = Clinical Neurophysiology, 46(1), 17-25. https://doi.org/10.1016/j.neucli.2015.12.009
Chanson E, et al. Anti-NMDA-R Encephalitis: Should We Consider Extreme Delta Brush as Electrical Status Epilepticus. Neurophysiol Clin. 2016;46(1):17-25. PubMed PMID: 26922283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-NMDA-R encephalitis: Should we consider extreme delta brush as electrical status epilepticus? AU - Chanson,Eve, AU - Bicilli,Élodie, AU - Lauxerois,Michel, AU - Kauffmann,Sophie, AU - Chabanne,Russell, AU - Ducray,François, AU - Honnorat,Jérome, AU - Clavelou,Pierre, AU - Rosenberg,Sarah, Y1 - 2016/02/26/ PY - 2015/07/26/received PY - 2015/12/29/accepted PY - 2016/2/29/entrez PY - 2016/2/29/pubmed PY - 2016/12/15/medline KW - Activité delta KW - Autoimmune encephalitis KW - Delta activity KW - Encéphalite auto-immune KW - N-methyl-d-aspartate receptor KW - Récepteur N-méthyl-d-aspartate KW - Status epilepticus KW - État de mal épileptique SP - 17 EP - 25 JF - Neurophysiologie clinique = Clinical neurophysiology JO - Neurophysiol Clin VL - 46 IS - 1 N2 - Seizures are common clinical manifestations in anti-N-methyl-d-aspartate receptor (anti-NMDA-R) encephalitis, among other neurological and psychiatric symptoms. During the course of the disease, some specific EEG patterns have been described: generalized rhythmic delta activity (GRDA) and extreme delta brush (EDB). In comatose patients, the association of these EEG abnormalities with subtle motor manifestations can suggest ongoing non-convulsive status epilepticus (NCSE). We report the case of a 28-year-old woman admitted for a clinical presentation typical of anti-NMDA-R encephalitis, which was confirmed by CSF analysis. She was rapidly intubated because of severe dysautonomia and disturbed consciousness. Clinical examination revealed subtle paroxysmal and intermittent myoclonic and tonic movements, correlated on video-EEG with GRDA and/or EDB. NCSE was then suspected, but electroclinical manifestations persisted despite many anti-epileptic drugs combinations, or reappeared when barbiturate anesthesia was decreased. In order to confirm or dismiss the diagnosis, intracranial pressure (ICP) and surface video-EEG monitoring were performed simultaneously and revealed no ICP increase, thus being strongly against a diagnosis of seizures. Sedation was progressively weaned, and clinical condition as well as EEG appearance progressively improved. Literature review revealed 11 similar cases, including 2 with focal NCSE. Of the nine other cases, NCSE diagnosis was finally excluded in 5 cases. NCSE diagnosis in association with anti-NMDA-R encephalitis is sometimes very difficult and its occurrence might be overestimated. Video-EEG is highly recommended and more invasive techniques may sometimes be necessary. SN - 1769-7131 UR - https://www.unboundmedicine.com/medline/citation/26922283/Anti_NMDA_R_encephalitis:_Should_we_consider_extreme_delta_brush_as_electrical_status_epilepticus L2 - https://linkinghub.elsevier.com/retrieve/pii/S0987-7053(16)00011-3 DB - PRIME DP - Unbound Medicine ER -