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Long-term effects of intrathecal baclofen in multiple sclerosis.
Clin Neurol Neurosurg. 2016 Apr; 143:121-5.CN

Abstract

OBJECTIVES

Spasticity is associated with various neurological conditions. In this study the authors analyzed the long term effects of intrathecal baclofen therapy in multiple sclerosis and evalued the benefits of the treatment on spasticity, disability, pain, spasm frequency and rated the incidence of side effects.

PATIENTS AND METHODS

A records of 123 patients, with a severe, progressive and refractory to medical therapy spasticity from different causes, underwent baclofen pump placement, after a bolus test, from 2000 to 2012,under Department of Neurosurgery at the Second University of Naples/Italy. We present our experience in treating 28 subjects that was affected by multiple sclerosis. For all patients we reviewed long-term response to therapy, surgical technique, surgery- and pump-related complications. Every patients were evaluated by means of the Modified Ashworth Scale (MAS), Penn Spasm Frequency Scale (SFS), Visual analogue Scale For Pain (VAS), Barthel index (BI) and Self Rating Depression Scale (SDS) RESULTS: During follow up the mean MAS score for upper and lower extremities decrease significantly. Also SFS's decrease was statistically significant. This resulted in a dramatic improvement of BI. Furthermore, we observed a marked improvement in VAS and SDS.

CONCLUSIONS

Intrathecal baclofen provides effective long-term treatment of spasticity multiple sclerosis related. ITB therapy increases the quality of lifestyle and functional independence in appropriately selected cases.

Authors+Show Affiliations

Department of Neurosurgery, Second University of Naples, SUN, Italy.Department of Neurosurgery, Second University of Naples, SUN, Italy. Electronic address: doriantonioraf@libero.it.Department of Neurosurgery, Second University of Naples, SUN, Italy.Department of Neurosurgery, Second University of Naples, SUN, Italy.Department of Neurosurgery, Second University of Naples, SUN, Italy.Department of Neurosurgery, Second University of Naples, SUN, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26922704

Citation

Natale, Massimo, et al. "Long-term Effects of Intrathecal Baclofen in Multiple Sclerosis." Clinical Neurology and Neurosurgery, vol. 143, 2016, pp. 121-5.
Natale M, D'Oria S, Nero VV, et al. Long-term effects of intrathecal baclofen in multiple sclerosis. Clin Neurol Neurosurg. 2016;143:121-5.
Natale, M., D'Oria, S., Nero, V. V., Squillante, E., Gentile, M., & Rotondo, M. (2016). Long-term effects of intrathecal baclofen in multiple sclerosis. Clinical Neurology and Neurosurgery, 143, 121-5. https://doi.org/10.1016/j.clineuro.2016.02.016
Natale M, et al. Long-term Effects of Intrathecal Baclofen in Multiple Sclerosis. Clin Neurol Neurosurg. 2016;143:121-5. PubMed PMID: 26922704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effects of intrathecal baclofen in multiple sclerosis. AU - Natale,Massimo, AU - D'Oria,Salvatore, AU - Nero,Veronica Venera, AU - Squillante,Eleonora, AU - Gentile,Marisa, AU - Rotondo,Michele, Y1 - 2016/02/16/ PY - 2014/05/09/received PY - 2016/02/04/revised PY - 2016/02/10/accepted PY - 2016/2/29/entrez PY - 2016/2/29/pubmed PY - 2016/12/22/medline KW - Intrathecal baclofen KW - Multiple sclerosis KW - Outcome KW - Spasticity SP - 121 EP - 5 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 143 N2 - OBJECTIVES: Spasticity is associated with various neurological conditions. In this study the authors analyzed the long term effects of intrathecal baclofen therapy in multiple sclerosis and evalued the benefits of the treatment on spasticity, disability, pain, spasm frequency and rated the incidence of side effects. PATIENTS AND METHODS: A records of 123 patients, with a severe, progressive and refractory to medical therapy spasticity from different causes, underwent baclofen pump placement, after a bolus test, from 2000 to 2012,under Department of Neurosurgery at the Second University of Naples/Italy. We present our experience in treating 28 subjects that was affected by multiple sclerosis. For all patients we reviewed long-term response to therapy, surgical technique, surgery- and pump-related complications. Every patients were evaluated by means of the Modified Ashworth Scale (MAS), Penn Spasm Frequency Scale (SFS), Visual analogue Scale For Pain (VAS), Barthel index (BI) and Self Rating Depression Scale (SDS) RESULTS: During follow up the mean MAS score for upper and lower extremities decrease significantly. Also SFS's decrease was statistically significant. This resulted in a dramatic improvement of BI. Furthermore, we observed a marked improvement in VAS and SDS. CONCLUSIONS: Intrathecal baclofen provides effective long-term treatment of spasticity multiple sclerosis related. ITB therapy increases the quality of lifestyle and functional independence in appropriately selected cases. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/26922704/Long_term_effects_of_intrathecal_baclofen_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(16)30054-3 DB - PRIME DP - Unbound Medicine ER -