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Clinicopathological characteristics and prognosis of schistosomal colorectal cancer.
Colorectal Dis. 2016 Oct; 18(10):1005-1009.CD

Abstract

AIM

The aim of the present study was to investigate the clinicopathological characteristics and prognostic factors of schistosomal colorectal cancer.

METHOD

A total of 74 consecutive schistosomal colorectal cancer patients who underwent curative surgery from July 2009 to July 2012 were included in this study. The clinical and pathological characteristics of all 74 patients were analysed and univariate and multivariate analyses were performed. This study demonstrated positive correlations between the site of deposition of schistosomal eggs and certain essential variables.

RESULTS

Depositional site of schistosome eggs, carcinoembryonic antigen (CEA) level and the pathological N and T stages were statistically significantly correlated with overall survival (OS). The pathological T stage and the CEA level were independent prognostic factors for OS. The site of deposition of schistosome eggs was positively correlated with the T and N stages, tumour size, the CEA level and the resection margins.

CONCLUSIONS

Schistosome eggs might be associated with tumorigenesis. The site of deposition of schistosome eggs was statistically significantly correlated with OS but it was not an independent prognostic factor for OS. It was, however, correlated with the depth of the tumour. The presence of schistosoma eggs at the margin did not affect the patient's prognosis or anastomotic healing. The existing standard surgical approach was equally applicable to schistosomal colorectal cancer. It was not necessary to expand the scope of surgical resection.

Authors+Show Affiliations

Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, China.Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, China.Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, China.Department of Gastroenterological Surgery, West China Hospital, Sichuan University, Chengdu, China. hxwangm@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26922912

Citation

Wang, M, et al. "Clinicopathological Characteristics and Prognosis of Schistosomal Colorectal Cancer." Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, vol. 18, no. 10, 2016, pp. 1005-1009.
Wang M, Wu QB, He WB, et al. Clinicopathological characteristics and prognosis of schistosomal colorectal cancer. Colorectal Dis. 2016;18(10):1005-1009.
Wang, M., Wu, Q. B., He, W. B., & Wang, Z. Q. (2016). Clinicopathological characteristics and prognosis of schistosomal colorectal cancer. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, 18(10), 1005-1009. https://doi.org/10.1111/codi.13317
Wang M, et al. Clinicopathological Characteristics and Prognosis of Schistosomal Colorectal Cancer. Colorectal Dis. 2016;18(10):1005-1009. PubMed PMID: 26922912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathological characteristics and prognosis of schistosomal colorectal cancer. AU - Wang,M, AU - Wu,Q B, AU - He,W B, AU - Wang,Z Q, PY - 2015/08/16/received PY - 2016/01/12/accepted PY - 2016/3/1/pubmed PY - 2017/7/15/medline PY - 2016/3/1/entrez KW - Schistosomiasis KW - clinicopathological characteristics KW - colorectal cancer KW - prognosis SP - 1005 EP - 1009 JF - Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland JO - Colorectal Dis VL - 18 IS - 10 N2 - AIM: The aim of the present study was to investigate the clinicopathological characteristics and prognostic factors of schistosomal colorectal cancer. METHOD: A total of 74 consecutive schistosomal colorectal cancer patients who underwent curative surgery from July 2009 to July 2012 were included in this study. The clinical and pathological characteristics of all 74 patients were analysed and univariate and multivariate analyses were performed. This study demonstrated positive correlations between the site of deposition of schistosomal eggs and certain essential variables. RESULTS: Depositional site of schistosome eggs, carcinoembryonic antigen (CEA) level and the pathological N and T stages were statistically significantly correlated with overall survival (OS). The pathological T stage and the CEA level were independent prognostic factors for OS. The site of deposition of schistosome eggs was positively correlated with the T and N stages, tumour size, the CEA level and the resection margins. CONCLUSIONS: Schistosome eggs might be associated with tumorigenesis. The site of deposition of schistosome eggs was statistically significantly correlated with OS but it was not an independent prognostic factor for OS. It was, however, correlated with the depth of the tumour. The presence of schistosoma eggs at the margin did not affect the patient's prognosis or anastomotic healing. The existing standard surgical approach was equally applicable to schistosomal colorectal cancer. It was not necessary to expand the scope of surgical resection. SN - 1463-1318 UR - https://www.unboundmedicine.com/medline/citation/26922912/Clinicopathological_characteristics_and_prognosis_of_schistosomal_colorectal_cancer_ L2 - https://doi.org/10.1111/codi.13317 DB - PRIME DP - Unbound Medicine ER -