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What are the Most Frequently Impaired Markers of Neurodegeneration in ADNI Subjects?
J Alzheimers Dis. 2016; 51(3):793-800.JA

Abstract

The aim of this study was to examine the relationship between cerebrospinal fluid (CSF) levels of biomarkers for Alzheimer's disease (AD) (Aβ1-42, t-tau, and p-tau) and 18Fluorodeoxyglucose positron emission tomography (FDG-PET) hypometabolism in subjects from the Alzheimer's Disease Neuroimaging Initiative, and specifically to determine which index of neurodegeneration was most frequently affected. The secondary objective was to determine the most frequently hypometabolic region in patients with a CSF AD signature (abnormal Aβ1-42 and abnormal p-tau). We included the 372 subjects (85 normal subjects, 212 patients with mild cognitive impairment, and 75 patients with AD) with a CSF biomarker dosage (Aβ1-42, t-tau, and p-tau) and brain FDG-PET. The relationship between FDG-PET metabolism (in five regions of interest (ROI) known to be damaged in AD) and CSF t-tau and p-tau levels was studied as a function of CSF Aβ1-42 status. FDG-PET hypometabolism and CSF t-tau and p-tau levels were correlated only in patients with an abnormal CSF Aβ1-42 level (t-tau: R2 = 0.044, p = 0.001; p-tau: R2 = 0.02, p = 0.03). In the latter patients, CSF p-tau was the most frequently (p = 0.0001) abnormal neurodegeneration marker (p-tau: 92.8%; FDG-PET: 56.5%; CSF t-tau: 59.1%). Within the five ROI of FDG PET, the angular gyrus metabolism (R2 = 0.149; p = 0.0001) was selected as the most tightly associated with CSF AD signature. The relation between CSF markers of neurodegeneration (p-tau and t-tau) and brain hypometabolism (in FDG-PET) is conditioned by presence of amyloid abnormality. This finding supports the current physiopathological model of AD. P-tau is the most frequently impaired biomarker. Using FDG PET angular gyrus hypometabolism is the most sensitive to CSF-biomarker-defined AD.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Andriuta D
Department of Neurology and Laboratory of Functional Neurosciences, University Hospital of Amiens, France.
Moullart V
Department of Nuclear Medicine, University Hospital of Amiens, France.
Schraen S
Department of Biology and Pathology, Lille University Hospital, France.
Devendeville A
Department of Neurology and Laboratory of Functional Neurosciences, University Hospital of Amiens, France. Department of Gerontology, University Hospital of Amiens, France.
Meyer ME
Department of Nuclear Medicine, University Hospital of Amiens, France.
Godefroy O
Department of Neurology and Laboratory of Functional Neurosciences, University Hospital of Amiens, France.
Alzheimer’s Disease Neuroimaging
No affiliation info available

MeSH

AgedAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersBrainCognitive DysfunctionDatabases, FactualFemaleFluorodeoxyglucose F18HumansMalePeptide FragmentsPhosphorylationPositron-Emission TomographyRadiopharmaceuticalstau Proteins

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26923012

Citation

Andriuta, Daniela, et al. "What Are the Most Frequently Impaired Markers of Neurodegeneration in ADNI Subjects?" Journal of Alzheimer's Disease : JAD, vol. 51, no. 3, 2016, pp. 793-800.
Andriuta D, Moullart V, Schraen S, et al. What are the Most Frequently Impaired Markers of Neurodegeneration in ADNI Subjects? J Alzheimers Dis. 2016;51(3):793-800.
Andriuta, D., Moullart, V., Schraen, S., Devendeville, A., Meyer, M. E., & Godefroy, O. (2016). What are the Most Frequently Impaired Markers of Neurodegeneration in ADNI Subjects? Journal of Alzheimer's Disease : JAD, 51(3), 793-800. https://doi.org/10.3233/JAD-150829
Andriuta D, et al. What Are the Most Frequently Impaired Markers of Neurodegeneration in ADNI Subjects. J Alzheimers Dis. 2016;51(3):793-800. PubMed PMID: 26923012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What are the Most Frequently Impaired Markers of Neurodegeneration in ADNI Subjects? AU - Andriuta,Daniela, AU - Moullart,Véronique, AU - Schraen,Susanna, AU - Devendeville,Agnes, AU - Meyer,Marc-Etienne, AU - Godefroy,Olivier, AU - ,, PY - 2016/3/1/entrez PY - 2016/3/1/pubmed PY - 2016/12/20/medline KW - Alzheimer’s disease KW - FDG-PET metabolism KW - cerebrospinal fluid biomarkers KW - neurodegeneration markers KW - tau SP - 793 EP - 800 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 51 IS - 3 N2 - The aim of this study was to examine the relationship between cerebrospinal fluid (CSF) levels of biomarkers for Alzheimer's disease (AD) (Aβ1-42, t-tau, and p-tau) and 18Fluorodeoxyglucose positron emission tomography (FDG-PET) hypometabolism in subjects from the Alzheimer's Disease Neuroimaging Initiative, and specifically to determine which index of neurodegeneration was most frequently affected. The secondary objective was to determine the most frequently hypometabolic region in patients with a CSF AD signature (abnormal Aβ1-42 and abnormal p-tau). We included the 372 subjects (85 normal subjects, 212 patients with mild cognitive impairment, and 75 patients with AD) with a CSF biomarker dosage (Aβ1-42, t-tau, and p-tau) and brain FDG-PET. The relationship between FDG-PET metabolism (in five regions of interest (ROI) known to be damaged in AD) and CSF t-tau and p-tau levels was studied as a function of CSF Aβ1-42 status. FDG-PET hypometabolism and CSF t-tau and p-tau levels were correlated only in patients with an abnormal CSF Aβ1-42 level (t-tau: R2 = 0.044, p = 0.001; p-tau: R2 = 0.02, p = 0.03). In the latter patients, CSF p-tau was the most frequently (p = 0.0001) abnormal neurodegeneration marker (p-tau: 92.8%; FDG-PET: 56.5%; CSF t-tau: 59.1%). Within the five ROI of FDG PET, the angular gyrus metabolism (R2 = 0.149; p = 0.0001) was selected as the most tightly associated with CSF AD signature. The relation between CSF markers of neurodegeneration (p-tau and t-tau) and brain hypometabolism (in FDG-PET) is conditioned by presence of amyloid abnormality. This finding supports the current physiopathological model of AD. P-tau is the most frequently impaired biomarker. Using FDG PET angular gyrus hypometabolism is the most sensitive to CSF-biomarker-defined AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/26923012/What_are_the_Most_Frequently_Impaired_Markers_of_Neurodegeneration_in_ADNI_Subjects DB - PRIME DP - Unbound Medicine ER -