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Increased dietary vitamin K intake is associated with less severe subjective memory complaint among older adults.
Maturitas 2016; 93:131-136M

Abstract

OBJECTIVES

Increased dietary intake of vitamin K, a fat-soluble nutrient involved in brain health and function, has been associated with better cognitive performance in older adults. Our objective was to determine whether the dietary vitamin K intake was associated with the presence and severity of subjective memory complaint among older adults.

STUDY DESIGN

Observational, cross-sectional cohort study.

MAIN OUTCOME MEASURES

One hundred sixty older adults taking no vitamin K antagonist were included. The daily dietary vitamin K intake was assessed using a 50-item food frequency questionnaire. The subjective memory complaint was assessed at the same time using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). Serious subjective memory complaint was defined as MAC-Q score ≤15. Age, gender, body mass index, education level, number of comorbidities, history of stroke, objective cognitive disorders, functional autonomy, mood, serum concentrations of vitamin B12, TSH, albumin, and estimated glomerular filtration rate were used as potential confounders.

RESULTS

Compared to participants without serious subjective memory complaint, those with serious subjective memory complaint (n=110) had a lower mean dietary vitamin K intake (298.0±191.8μg/day versus 393.8±215.2μg/day, P=0.005). Increased log dietary vitamin K intake was positively associated with the MAC-Q score used as a quantitative variable (fully adjusted β=0.79, P=0.031), and inversely with serious subjective memory complaint (fully adjusted OR=0.34, P=0.017).

CONCLUSIONS

Increased dietary vitamin K intake was associated with fewer and less severe subjective memory complaint in older adults taking no vitamin K antagonists. These findings provide epidemiological data supporting future vitamin K replacement trials.

Authors+Show Affiliations

Department of Family Medicine, School of Medicine, University of Angers, UNAM, Angers, France.Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada.Department of Geriatric Medicine, Institut du Vieillissement, University Hospital; INSERM-U1027, Toulouse, France.Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada.Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada.Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000 Bordeaux, France; INSERM, ISPED, INSERM U897-Epidemiologie-Biostatistique, F-33000 Bordeaux, France.Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital; Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada. Electronic address: CeAnnweiler@chu-angers.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26923488

Citation

Soutif-Veillon, Anne, et al. "Increased Dietary Vitamin K Intake Is Associated With Less Severe Subjective Memory Complaint Among Older Adults." Maturitas, vol. 93, 2016, pp. 131-136.
Soutif-Veillon A, Ferland G, Rolland Y, et al. Increased dietary vitamin K intake is associated with less severe subjective memory complaint among older adults. Maturitas. 2016;93:131-136.
Soutif-Veillon, A., Ferland, G., Rolland, Y., Presse, N., Boucher, K., Féart, C., & Annweiler, C. (2016). Increased dietary vitamin K intake is associated with less severe subjective memory complaint among older adults. Maturitas, 93, pp. 131-136. doi:10.1016/j.maturitas.2016.02.004.
Soutif-Veillon A, et al. Increased Dietary Vitamin K Intake Is Associated With Less Severe Subjective Memory Complaint Among Older Adults. Maturitas. 2016;93:131-136. PubMed PMID: 26923488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased dietary vitamin K intake is associated with less severe subjective memory complaint among older adults. AU - Soutif-Veillon,Anne, AU - Ferland,Guylaine, AU - Rolland,Yves, AU - Presse,Nancy, AU - Boucher,Kariane, AU - Féart,Catherine, AU - Annweiler,Cedric, Y1 - 2016/02/11/ PY - 2015/11/21/received PY - 2016/01/27/revised PY - 2016/02/09/accepted PY - 2016/3/1/pubmed PY - 2017/4/30/medline PY - 2016/3/1/entrez KW - Aging KW - Cognition KW - Diet KW - Neuroendocrinology KW - Subjective memory complaint KW - Vitamin K SP - 131 EP - 136 JF - Maturitas JO - Maturitas VL - 93 N2 - OBJECTIVES: Increased dietary intake of vitamin K, a fat-soluble nutrient involved in brain health and function, has been associated with better cognitive performance in older adults. Our objective was to determine whether the dietary vitamin K intake was associated with the presence and severity of subjective memory complaint among older adults. STUDY DESIGN: Observational, cross-sectional cohort study. MAIN OUTCOME MEASURES: One hundred sixty older adults taking no vitamin K antagonist were included. The daily dietary vitamin K intake was assessed using a 50-item food frequency questionnaire. The subjective memory complaint was assessed at the same time using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). Serious subjective memory complaint was defined as MAC-Q score ≤15. Age, gender, body mass index, education level, number of comorbidities, history of stroke, objective cognitive disorders, functional autonomy, mood, serum concentrations of vitamin B12, TSH, albumin, and estimated glomerular filtration rate were used as potential confounders. RESULTS: Compared to participants without serious subjective memory complaint, those with serious subjective memory complaint (n=110) had a lower mean dietary vitamin K intake (298.0±191.8μg/day versus 393.8±215.2μg/day, P=0.005). Increased log dietary vitamin K intake was positively associated with the MAC-Q score used as a quantitative variable (fully adjusted β=0.79, P=0.031), and inversely with serious subjective memory complaint (fully adjusted OR=0.34, P=0.017). CONCLUSIONS: Increased dietary vitamin K intake was associated with fewer and less severe subjective memory complaint in older adults taking no vitamin K antagonists. These findings provide epidemiological data supporting future vitamin K replacement trials. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/26923488/Increased_dietary_vitamin_K_intake_is_associated_with_less_severe_subjective_memory_complaint_among_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(16)30019-6 DB - PRIME DP - Unbound Medicine ER -